A5105977286- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Helminth infection and control
- Aquaculture disease management and microbiota
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Allergic Rhinitis and Sensitization
- Studies on Chitinases and Chitosanases
- Inflammasome and immune disorders
- Photoreceptor and optogenetics research
- Immune cells in cancer
- Invertebrate Immune Response Mechanisms
- IL-33, ST2, and ILC Pathways
- Thermal Regulation in Medicine
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Glutathione Transferases and Polymorphisms
- Marine Biology and Environmental Chemistry
- Occupational and environmental lung diseases
- Ion Channels and Receptors
China Pharmaceutical University
2018-2024
Baylor College of Medicine
1994-2024
Shanghai Pulmonary Hospital
2024
Tongji University
2024
Southwest University
2024
East China University of Science and Technology
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Baylor School
2023
Guangdong Ocean University
2023
Wuhan University
2021-2023
Abstract Responses of the insular cortex (IC) and amygdala to stimuli positive negative valence are altered in patients with anxiety disorders. However, neural coding both by IC neurons remains unknown. Using fiber photometry recordings mice, we uncover a selective increase activity projection anterior (aIC), but not posterior (pIC) section, when animals exploring anxiogenic spaces, this is proportional level mice. Neurons aIC also respond valence, strength response strong mice levels...
Abstract Bloodborne infections with Candida albicans are an increasingly recognized complication of modern medicine. Here, we present a mouse model low-grade candidemia to determine the effect disseminated infection on cerebral function and relevant immune determinants. We show that intravenous injection 25,000 C. cells causes highly localized cerebritis marked by accumulation activated microglial astroglial around yeast aggregates, forming fungal-induced glial granulomas. Amyloid precursor...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome considered an important regulator of immunity and inflammation, both which play critical role MS. However, underlying mechanism activation not fully understood. Here we identified that TRPV1 (transient receptor potential vanilloid type 1) channel microglia, as Ca2+ influx-regulating channel, played activation. Deletion or pharmacological blockade inhibited...
Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses lung cancer remains unknown. Here, we show that nCB increased PD-L1
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of anti-Candida immunity remains unknown. We show that C. enters mouse from blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) candidalysin. Saps disrupt tight junction proteins blood-brain barrier (BBB) permit invasion. also hydrolyze amyloid precursor protein (APP) into β (Aβ)-like peptides bind Toll-like...
The Ca2+ release channel of skeletal muscle sarcoplasmic reticulum is modulated in a biphasic manner by the plant alkaloid ryanodine and there are two distinct binding sites on this for ryanodine. homotetramer with subunit 5037 amino acids. ability membranes to bind [3H]ryanodine high affinity site lost upon proteolysis trypsin. [3H]Ryanodine, however, bound before remains after trypsin digestion. If first occupied then 100 microM added occupy low sites, almost all proteolysis. Proteolysis...
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which a partial agonist 1A receptor (5-HT1A). Similarly, ligands 2A (5-HT2A) were shown to alter anxiety level. 5-HT1A and receptors are widely expressed across brain, but region(s) underlying influence those on remain unknown. Interestingly, recent studies in human non-human primates have that 5-HT2A binding potentials within insular cortex (insula) correlated anxiety. As an initial step define function...
Abstract Multiple sclerosis (MS) is a chronic disease that characterized by demyelination and neuronal damage. Experimental autoimmune encephalomyelitis (EAE) mice are used to model the progression of MS mirror MS-like pathology. Previous researches have confirmed inhibition NLRP3 inflammasome significantly alleviated severity EAE spinal cord, but its effect on damage oligodendrocyte loss in brain remains unclear. In this study, female C57BL/6 were immunized with MOG35–55 PTX establish...
Objective The objective of this study was to investigate the impact electro-acupuncture (EA) on sepsis-related intestinal injury and its relationship with macrophage polarization. Methods A sepsis model established using cecal ligation puncture (CLP) assess effectiveness EA. extent pathological evaluated Chiu’s score, expression ZO-1 Ocludin, polarization examined through flow cytometry immunofluorescence staining. spermidine, one type polyamine, ornithine decarboxylase (ODC) measured ELISA...
Ascariasis (roundworm) is the most prevalent parasitic nematode infection worldwide, impacting approximately 500 million people predominantly in low- and middle-income countries (LMICs). While of all ages are infected with Ascaris , intensity (defined by worm burden) paradoxically peaks pre-school school-aged children but then declines age. The cause age-dependent not well understood may be dependent on cellular changes mucosal barrier sites. We have previously found that gastric mucosa a...
Ascariasis is one of the most common infections in world and associated with significant global morbidity. Ascaris larval migration through host's lungs essential for development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether can subsequently lead chronic lung diseases remains unknown. Here, we demonstrate that a single episode induces pulmonary syndrome inflammatory pathology emphysema accompanied by...
Ascariasis (roundworm) is the most common parasitic helminth infection globally and can lead to significant morbidity in children including chronic lung disease. Children become infected with Ascaris spp. via oral ingestion of eggs. It has long been assumed that egg hatching larval translocation across gastrointestinal mucosa initiate occurs small intestine. Here, we show A . suum larvae hatched host stomach a murine model. Larvae utilize acidic mammalian chitinase (AMCase; acid chitinase;...
The genetic regulation of goose meat quality traits remains relatively unexplored, and the underlying mechanisms are yet to be elucidated. This study aims employ single nucleotide polymorphism (SNP) genotyping in conjunction with genome-wide association studies (GWAS) investigate critical candidate regions genes associated pH trait Sichuan white geese. A cohort 203 healthy male geese was randomly selected slaughtered at 70 days age. Measurements were taken pH, growth parameters, body...
Lung abscess in the apical segment of lung is not rare and often underestimated clinical practice. However, features (AL) have scarcely been reported. Hence, this study aimed to determine characteristics AL explore moderate therapeutic strategies.
Thioredoxin reductases are frequently overexpressed in various solid tumors as a protective mechanism against heightened oxidative stress. Inhibitors of this system, such Auranofin, effective eradicating cancer cells. However, the clinical significance thioredoxin reductase 1 (TrxR1) lung cancer, well potential for its antagonist treatment option, necessitated further experimental validation. In study, we observed significant upregulation TrxR1 specifically non-small cell (NSCLC), rather...
and
Abstract The response of the insular cortex (IC) and amygdala to stimuli positive negative valence were found be altered in patients with anxiety disorders. However, coding properties neurons controlling remain unknown. Combining photometry recordings chemogenetics mice, we uncover anxiogenic control projection anterior IC (aIC), independently their target. Using viral tracing ex vivo electrophysiology, characterize monosynaptic aIC basolateral (BLA) connection, employed projection-specific...