A5100671641- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Advanced Statistical Process Monitoring
- Neuroscience and Neuropharmacology Research
- Advanced Statistical Methods and Models
- Nuclear Receptors and Signaling
- Fault Detection and Control Systems
- Axon Guidance and Neuronal Signaling
- Industrial Vision Systems and Defect Detection
- Ion Channels and Receptors
- Neurological Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Hereditary Neurological Disorders
- Phytoestrogen effects and research
- Stress Responses and Cortisol
- Air Quality and Health Impacts
- Research, Science, and Academia
- Neurogenesis and neuroplasticity mechanisms
- Stock Market Forecasting Methods
- Pharmacological Effects of Natural Compounds
- Lipid Membrane Structure and Behavior
- Hydrogen's biological and therapeutic effects
- Tryptophan and brain disorders
- Nutrition, Health and Food Behavior
Zhongnan Hospital of Wuhan University
2004-2024
Wuhan University
2004-2024
Wuxi No.2 People's Hospital
2022-2023
Jiangnan University
2008-2023
Nanjing Medical University
2022
Nanjing University of Chinese Medicine
2022
Zhengzhou University
2008-2020
Zhengzhou Business University
2018-2020
Qufu Normal University
2015
Beijing Center for Disease Prevention and Control
2010
The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity brain region-specific pattern. Functional alterations of reactive are commonly present human temporal lobe epilepsy (TLE) cases, meanwhile neuroinflammation mediated by may advance development hippocampal animal models. Nuclear factor I-A (NFIA) regulate astrocyte adult brain. However, whether NFIA endows with regional specificity to be involved epileptogenesis remains elusive.Here, we utilize...
Depression is one of the most common complications in patients with diabetes. Our previous study demonstrated puerarin, a dietary isoflavone, improved glucose homeostasis and β-cell regeneration high-fat diet (HFD)-induced diabetic mice. Here, we aim to evaluate potential effect puerarin on diabetes-induced depression.The co-occurrence diabetes depression related biochemical alterations were confirmed HFD mice db/db mice, respectively using behavioral analysis, ELISA western blotting assay....
Abstract Aims Multiple guidance cues, such as netrin‐1 (NTN‐1)/deleted in colorectal carcinoma (DCC), control the of axons and help establish functional neural circuits during development. However, function these molecules neurodegenerative process is unclear. Methods To access alterations NTN‐1 DCC onset progression PD, we first established two subacute one chronic PD model. Then, investigated relationship between NTN‐1/DCC pathway cell death SH‐SY5Y cells. Finally, conducted correlation...
Aging is a multifactorial process involving the cumulative effects of inflammation, oxidative stress, and mitochondrial dynamics, which can produce complex structural biochemical alterations to nervous system lead dysfunction microcirculation, blood-brain barrier (BBB), other problems in brain. Long-term injection D-galactose (D-gal) induce chronic inflammation accelerating aging. The model accelerated aging with long-term administration D-gal have been widely used anti-aging studies, due...
Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal mortality, resulting in injury and persistent seizures that can last into the late period beyond. Effective treatments interventions for infants affected by hypoxia-ischemia remain lacking. Clinical investigations have indicated an elevation nuclear factor activated T cells 5 (NFAT5) whole blood from umbilical cords severely HIBD with epilepsy. Experimental research has demonstrated NFAT5 ambivalent effects on...
A global uncertainty environment, such as the COVID-19 pandemic, has affected manufacturing industry severely in terms of supply and demand balancing. So, it is common that one stage statistical process control (SPC) chart affects next-stage SPC chart. It our research objective to consider a conditional case for multi-stage multivariate change point detection (CPD) model highly correlated data via copula distributions with principal component analysis (PCA) functional PCA (FPCA). First all,...
Objective To assess the efficacy and safety of dl-3-n-butylphthalide injection in acute ischemic stroke patients. Methods A randomized, double-blind, double-dummy trial enrolled 552 patients China, if they were within 48 hours onset stroke, had a score from 6 to 25 on National Institutes Health Stroke Scale (NIHSS). Three hundred seventy randomly assigned receive infusion 182 received ozagrel. Results In group, NIHSS at baseline, 8th 15th days 8.64±3.03,6.45±3.88 4.71±3.90...
Celastrol, the primary constituent of Tripterygium wilfordii, has demonstrated neuroprotective properties in rats with dementia by reducing inflammation. A high-fat diet and streptozotocin injection were utilized to establish a diabetic rat model, which was then employed investigate possible protective effect celastrol against development diabetes-induced learning memory deficits. Afterwards, experimental animals received dose gavage (4 mg/kg/d). An animal study showed that enhanced insulin...
Immune function and antioxidant defense play an important role in protecting animals against pathogens controlling oxidative stress, respectively. Aldicarb is of great concern for human health due to its toxic nature, extensive usage consequent pollution. The hypothesis that aldicarb exposure would suppress immune capacity Kunming mice was be tested the present study. Twenty-three adult male were randomly divided into control (n = 11) treated 12) groups. Food water provided ad libtum both...
Feedback is the trading strategy of irrational investors. Positive feedback traderspsila buying or selling behavior decided by stock price preceding period. On presence positive trading, market returns show characteristics which are different from these assumed in classical financial theory, and thus make fluctuate extraordinarily. This essay establishes a model with participation trader rational trader. The traders adopt strategy. Based on model, we used Monte Carlo simulation method to...
Objective To investigate the effect of wogonin on ethology and its possible mechanisms in chronic cerebral ischemia rats. Methods Ratswere randomly divided into a sham operation group, awogonin intervention phosphate buffered solution(PBS) control group. A rat model was induced by two-vessel occlusion method. Six weeks after modeling, rats group PBS were intragastric administrated with (50μmol/L, 10 ml/kg, once day)and equal volume for 14 days. Morris water maze test used to evaluate...
Objective To investigate the expression of adiponectin (APN) and clinical significance in type 2 diabetic rats with cerebral ischemic reperfusion damage.Methods One hundred four SD were randomly divided into two groups,including normal diet group (n=52) (n=52); middle artery occlusion was performed some to induce ischemia injury models.Normal then euglycemia (n=8) (I/R,n-44); diabetes groups complicated (DM+I/R,n=44).The blood collected detect APN changes from tail vein (n=4) DM+I/R before...
Objective To investigate the neuroprotective effect of escitaloprarn on focal cerebral ischemia/ reperfilsion in rats and its possible mechanisms. Methods Seventy-five male Sprague-Dawley were randomly divided into three groups： sham operation, saline control escitalopram intervention groups （n = 25 each group）. A ischemia reperfusion model was induced by intraluminal suture method. The modified neurological severity scale used to evaluate deficit 5 Laser confocal technology observe...
PP-30-094 Background/Aims: To assess drinking water health risk for Beijing residents. Methods: We had interviewed 270 residents of resident (≥12 years age) during November to December in 2009. used a multistage sampling method the intake between weekends and weekdays. First, 5 counties were drawn from region by simple random sample. Second, 27 districts randomly taken counties. Third, 2 blocks/villages sampled districts. Fourth, families blocks. Finally, 1 person was KISH table. Results:...
Objective To detect the alteration of circulating CD34^＋ cell level in patients with first-ever nonlactmar stroke and to investigate prognostic value level. Methods The cells were examined using flow cytometry 119 nonlacunar infarction. divided into group A （higher than average） B （lower according detected values. National Institutes Health Stroke Scale （NIHSS） scores on admission modified Rankin （mRS） at 3 months after onset two groups compared. Results was significantly higher that （0. 048...
Abstract Multiple guidance cues, such as netrin-1 (NTN-1)/deleted in colorectal carcinoma (DCC), control the of axons and help establish functional neural circuits during development. However, function these molecules adult brain, particularly neurodegenerative process, is unclear. NTN-1 its receptor DCC play a critical role development midbrain dopamine circuitry. To access alterations onset progression PD, we first established two subacute one chronic PD model found that imbalance was...