A5042901476- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ion channel regulation and function
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Mycobacterium research and diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- FOXO transcription factor regulation
- Liver Disease Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Endoplasmic Reticulum Stress and Disease
- SARS-CoV-2 detection and testing
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
Jiangxi Provincial Institute of Water Sciences
2025
Wuhan University
2014-2024
OriginWater (China)
2024
Zhangjiagang First People's Hospital
2013-2023
Soochow University
2013-2023
Zhongnan Hospital of Wuhan University
2012-2023
GTx (United States)
2018
Hubei University of Chinese Medicine
2016-2017
Creative Commons
2015
Johns Hopkins Medicine
2002-2012
Breast cancer is the most common type in female. As microRNAs play vital role breast cancer, this study aimed to explore molecular mechanism and clinical value of miR-21 cancer. qRT-PCR was performed detect levels plasma 127 healthy controls, 82 benign tumor, 252 patients, as well cell lines. Transwell wound healing assay were used analyze metastasis response inhibitor. Colony formation eFluor™ 670 based flow cytometric analysis test proliferation following inhibitor treatment. Leucine...
Circular RNAs (circRNA), a class of noncoding RNAs, have been found to be involved in various diseases. Here, the expression levels circRNA hsa_circ_0001445 73 pairs hepatocellular carcinoma (HCC) and adjacent nontumor tissues were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). Our data demonstrate that significantly decreased HCC (P < 0.001) markedly associated with number tumor foci = 0.014). Furthermore, vitro approaches showed overexpression promoted...
LncRNAs play critical roles in gastric cancer (GC). In this study, the expression of fourteen related lncRNAs were investigated paired tissues 66 patients with GC, real-time RT-PCR revealed that ZFAS1 was significantly upregulated. We then examined plasmas derived from 77 GC before- and post-operations 60 healthy individuals, found circulating also upregulated operation can reduce its presence plasma. To investigate potential mechanisms, we compared multiple cell lines one normal line...
Homer proteins form an adapter system that regulates coupling of group 1 metabotropic glutamate receptors with intracellular inositol trisphosphate and is modified by neuronal activity. Here, we demonstrate also physically associate ryanodine type (RyR1) regulate gating responses to Ca<sup>2+</sup>, depolarization, caffeine. In contrast the prevailing notion function, Homer1c (long form) Homer1-EVH1 (short evoke similar changes in RyR The EVH1 domain mediates these actions selectively...
Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense (HOTAIR) has been reported to play a vital role in various cancers. It found that HOTAIR was upregulated non–small cell lung cancer (NSCLC) and involved invasion metastasis. The aberrant expression of is expected serve as potential biomarker for patients with NSCLC. Our aim this study detect the plasma levels further evaluate its diagnostic value were measured 105 NSCLC 80 healthy controls by quantitative real-time...
Background: Circular RNAs (circRNAs) are a class of widely distributed non-coding RNAs, which drew little attention for decades. Recent studies show that circRNAs involved in cancer progression. Methods: The circSMAD2 expression HCC and adjacent non-tumor tissues was measured by quantitative real-time polymerase chain reaction, the biological function explored proliferation, apoptosis, migration, invasion, Western blot assays. Next, dual-luciferase reporter assay performed to identify target...
Acting as a tumor suppressor, microRNA (miR)-125b shows aberrant low expression in hepatocellular carcinoma (HCC), and researchers have found that its dysregulation has close relationship with hepatitis B virus (HBV) infection. Here, we investigated the profile of this miRNA plasma healthy subjects patients chronic HBV-related liver diseases order to confirm feasibility circulating differential diagnostic biomarker for HBV-induced HCC (HBV-HCC).A total 242 individuals were enrolled study....
Non-small cell lung cancer (NSCLC) is one of the most malignant cancers in world. Early diagnosis NSCLC has become especially important for patient treatment and prognosis. Increasing evidence suggest that long non-coding RNA GAS5 plays vital roles proliferation differentiation NSCLC. However, its clinical value unclear. The objective this study was to evaluate importance circulating as a biomarker diagnosis. In our study, quantitative real-time PCR (QRT-PCR) applied detect expression level...
Breast cancer is the leading cause of oncological mortality among women. Efficient detection cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) critical regulators fundamental cellular processes a variety including breast cancer. The functional details these regulatory elements, however, remain largely unexplored.In this study, lncRNA ROR (linc-ROR) was...
BACKGROUND:Circular RNAs (circRNA)are involved in the progression of cancers, and previous study showed that hsa_circ_0001649 expression is down-regulated hepatocellular carcinoma (HCC). OBJECTIVE:To explore whether a prognostic biomarker for HCC to investigate biolog ical functions HCC. METHODS: Hsa_circ_0001649 was measured 77 pairs adjacent no-tumor tissues by quantitative Real-Time polymerase chain reaction. Kaplan-Meier curve Cox regression were used analyze its significance patients....
Objective . Long noncoding RNAs (lncRNAs) have been reported to play vital roles in non-small-cell lung cancer (NSCLC). Recently, long RNA Linc00152 has important various cancers. In this study, our aim was investigate its expression pattern and clinical significance further evaluate diagnostic value for NSCLC. Methods The levels of were detected NSCLC tissues plasma samples by quantitative real-time PCR (qRT-PCR). Receiver operating characteristic (ROC) curves depicted the value. Results We...
MicroRNAs (miRNAs) are small, non-coding RNAs that play important roles in the carcinogenesis and progression of cancers. Aberrant expression miRNAs tissue plasma has been found various solid tumors. Our research aims to determine whether abnormal miRNA patterns can be used as a predictive marker for diagnosis prognosis small cell lung cancer (SCLC). Fifty SCLC patients 30 healthy controls annotated with clinical characteristics specific questionnaire survey smoking history were available....
Background Recent studies reported that serum anion gap could be regarded as a prognostic biomarker for patients admitted to intensive care units. However, the association between AG and mortality in cerebral infarction remained largely unknown.Methods Relevant clinical data were collected from Medical Information Mart Intensive Care III. Patients divided into three groups according tertiles of AG. Kaplan–Meier curve Cox proportional hazards models used evaluate levels all-cause mortality....
The persistent challenge of achieving cost-effective total phosphorus (TP) removal in wastewater treatment necessitates innovative coagulant development. While polyaluminum chloride (PAC) demonstrates efficacy eliminating nitrogen (TN), ammonia (NH4+-N), suspended solids (SSs), and pH stabilization, its limitations attaining economical TP remain unresolved. This study introduces a novel FeSO4-Al2(SO4)3 composite to address PAC’s shortcomings through systematic formulation optimization....
Hepatocellular carcinoma (HCC) is the most common solid tumor in global range, with high degree of malignancy and poor prognosis. But relationship between expression GAS5-AS1 HCC not documented. This study aimed to profile signature then explore its clinical significance HCC.Quantitative real-time PCR (RT-qPCR) was performed detect 83 pairs surgical tissues adjacent normal liver tissues. We also RT-qPCR on plasma samples 156 patients 58 healthy controls.We found that down-regulated (P<...