A5100677895- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Telomeres, Telomerase, and Senescence
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Dermatology and Skin Diseases
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
Zhongnan Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
Memorial Sloan Kettering Cancer Center
2017-2022
Hubei Provincial Center for Disease Control and Prevention
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
First People’s Hospital of Jingmen
2022
Wuhan Center for Disease Control and Prevention
2021
Taichung Veterans General Hospital
2017
National Chung Hsing University
2014-2016
New York University
2009-2015
The growing number of Next Generation Sequencing (NGS) tests is transforming the routine clinical diagnosis hereditary cancers. Identifying whether a cancer result an underlying disease-causing mutation in predisposition gene not only diagnostic for syndrome, but also has significant implications management patients and their families. Here, we evaluated performance MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling Actionable Cancer Targets) detecting genetic alterations 76...
The purpose of this study was to determine the role long-chain fatty acyl-CoA synthetase 4 (ACSL4) in breast cancer. Public databases were utilized analyze relationship between ACSL4 mRNA expression and presence steroid hormone human epidermal growth factor receptor 2 (HER2) both cancer cell lines tissue samples. In addition, assess consequences either increased or decreased levels expression. Proliferation, migration, anchorage-independent apoptosis used as biological end points. Effects on...
Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect potentially probiotic strain, Lactobacillus pentosus GMNL-77, imiquimod-induced hyperplasia psoriasis-like inflammation BALB/c mice. Oral administration L. GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that...
Abstract We collected blood from coronavirus disease 2019 (COVID-19) convalescent individuals and investigated SARS-CoV-2-specific humoral cellular immunity in these discharged patients. Follow-up analysis a cohort of 171 patients at 4–11 months after the onset revealed high levels IgG antibodies. A total 78.1% (164/210) specimens tested positive for neutralizing antibody (NAb). SARS-CoV-2 antigen peptide pools-stimulated-IL-2 -IFN-γ response can distinguish COVID-19 healthy donors....
The microRNA-34a (miR-34a), a tumor-suppressive microRNA (miRNA), is implicated in epithelial-mesenchymal transition (EMT) and cancer stem cells. Lymphoid enhancer-binding factor-1 (LEF1) key transcription factor the Wnt signaling pathway, has been suggested to be involved regulation of cell proliferation invasion. Here, molecular mechanism miR-34a LEF1 cooperatively regulating prostate invasion described. Molecular profiling analysis miRNA levels cells revealed negative correlation between...
Protein arginine methyltransferase 5 (PRMT5) plays multiple roles in a large number of cellular processes, and its subcellular localization is dynamically regulated during mouse development differentiation. However, little known the functional differences between PRMT5 cytoplasm nucleus. Here, we demonstrated that predominantly localized prostate cancer cells. Subcellular assays designed to span entire open-reading frame protein revealed presence three nuclear exclusion signals (NESs)...
Inflammation indicators, such as systemic inflammation response index (SIRI), immune-inflammation (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR), are associated with poor prognosis in various solid cancers. In this study, we investigated the predictive value of these indicators nasopharyngeal carcinoma (NPC). This retrospective study involved 559 patients NPC 500 chronic rhinitis, 255 were followed up successfully. Continuous variables qualitative measured by t...
Detection of serum tumor markers has been developed as a non-invasive tool to assess treatment efficiency in different types cancer. This study aims investigate the role preoperative (CEA, CA125 and CA15-3) management breast cancer, their relationships with patients' clinicopathological parameters well molecular subtypes. Altogether, 151 patients invasive cancer 180 control subjects benign diseases were enrolled this study. In present study, levels CEA, CA15-3 significantly higher than...
The clinical presentation of SARS-CoV-2-infected pneumonia (COVID-19) resembles that other etiologies community-acquired (CAP). We aimed to identify laboratory features distinguish COVID-19 from CAP.
Copper ions (Cu<sup>2+</sup>) and <sc>l-</sc>cysteine (<sc>l-</sc>Cys) in the human body always play critical roles various physiological processes, while abnormal Cu<sup>2+</sup> <sc>l-</sc>Cys concentrations biological system lead to many diseases.
The biological activity of the edible basidiomycete Antrodia cinnamomea (AC) has been studied extensively. Many effects, such as anti-cancer, anti-inflammatory, and antioxidant activities, have reported from either crude extracts or compounds isolated AC. However, research addressing function AC in enhancing immunity is rare. aim present study to investigate active components mechanism involved immunostimulatory effect We found that polysaccharides (PS) water extract played a major role...
Long non-coding RNA (lncRNA) can act as ceRNA to regulate the expression of target genes by sponging miRNAs, and therefore plays an essential role in tumor initiation progression. However, functional roles regulatory mechanisms lncRNAs ceRNAs head neck squamous cell carcinoma (HNSCC) remains be determined. In current study, we explored a genome-wide analysis confirm potential lncRNA-associated network. The mRNAs, miRNAs sequence profiles were downloaded from availably accessed Cancer Genome...
The development of new effective therapeutic agents with minimal side effects for prostate cancer (PC) treatment is much needed. Indirubin, an active molecule identified in the traditional Chinese herbal medicine-Qing Dai (Indigo naturalis), has been used to treat leukemia decades. However, anticancer properties Natura-alpha, indirubin derivative, are not well studied solid tumors, particularly PC.The growth kinetics and invasion ability on human PC cell lines or without Natura-alpha were...
// Yunbao Pan 1, 2, * , Guohong Liu 3, 4, Yufen Yuan 5 Jin Zhao 1 Yong Yang 6 and Yirong Li Department of Laboratory Medicine, Zhongnan Hospital Wuhan University, Wuhan, Hubei, China 2 Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Guangzhou, Guangdong, 3 Radiology, 4 School Materials Science Engineering Electronics Information technology, Pathology, Anyang Anyang, Henan, Key Zoonsis Research Ministry Education, Institute Zoonosis, Jilin Changchun, Jilin, These authors contributed...