A5101998407- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- SARS-CoV-2 detection and testing
- Immune cells in cancer
- Viral Infections and Vectors
- Allergic Rhinitis and Sensitization
- Berberine and alkaloids research
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- COVID-19 epidemiological studies
- Drug Transport and Resistance Mechanisms
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Phytochemical and Pharmacological Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- Herbal Medicine Research Studies
- Vector-Borne Animal Diseases
- Medical Research and Treatments
Zhongnan Hospital of Wuhan University
2020-2025
Wuhan University
2020-2025
Guangzhou University of Chinese Medicine
2025
Longgang Central Hospital
2018-2025
Union Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Shenzhen University
2015-2024
State Key Laboratory of Respiratory Disease
2022
Wuhu Fourth People Hospital
2021
Xian Yang Central Hospital
2021
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colon, and it has become one world-recognized medical problems as recurrent refractory.Berberine (BBR) effective drug for UC treatment.However, underlying mechanism targets remain obscure.In this study, we systematically investigated therapeutic effect its BBR in ameliorating DSS-induced mouse colitis.Expectedly, colon inflammation was significantly relieved by BBR, microbiota depletion antibiotic cocktail...
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induced Disease 2019 (COVID-19) has posed a global threat to public health. The immune system is crucial in defending and eliminating the virus infected cells. However, dysregulation may result rapid progression of COVID-19. Here, we evaluated subsets, phenotypic functional characteristics natural killer (NK) T cells patients with COVID-19 their associations disease severity. Methods: Demographic clinical data enrolled...
Since December 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. COVID-19 patients demonstrated significantly different outcomes clinic. We aimed to figure out whether obesity is a risk factor influencing the progression prognosis of COVID-19.95 with were divided into group non-obesity according their body mass index (BMI). The demographic data, clinical characteristics, laboratory examination, chest computed tomography...
Macrophage polarization is closely associated with the pathogenesis of ulcerative colitis (UC). Quercetin, a flavonoid, has shown promise as treatment for inflammatory diseases, but its specific mechanism action remains unclear. This study investigates whether quercetin can regulate intestinal macrophage and promote tissue repair via cGAS-STING pathway UC. In vivo , mice 3% DSS-induced UC were intraperitoneally injected RU.521 7 days, following which their general conditions corresponding...
An outbreak of pneumonia caused by a novel coronavirus (COVID-19) began in Wuhan, China December 2019 and quickly spread throughout the country world. efficient convenient method based on clinical characteristics was needed to evaluate potential deterioration patients. We aimed develop simple practical risk scoring system predict severity COVID-19 patients admission. retrospectively investigated information confirmed from 10 February 2020 29 Wuhan Union Hospital. Predictors were identified...
Abstract An outbreak of new coronavirus SARS-CoV-2 was occurred in Wuhan, China and rapidly spread to other cities nations. The standard diagnostic approach that widely adopted the clinic is nuclear acid detection by real-time RT-PCR. However, false-negative rate technique unneglectable serological methods are urgently warranted. Here, we presented colloidal gold-based immunochromatographic (ICG) strip targeting viral IgM or IgG antibody compared it with sensitivity ICG assay combinatorial...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by many factors including colonic inflammation and microbiota dysbiosis. Previous studies have indicated that celastrol (CSR) has strong anti-inflammatory immune-inhibitory effects. Here, we investigated the effects of CSR on mucosal immunity in an experimental model, addressed mechanism which exerts protective We characterized therapeutic potential treating UC using histological staining, intestinal permeability assay,...
Severe fever with thrombocytopenia syndrome (SFTS) is a viral infection primarily found in Asia, case fatality rate of about 10%. Despite its increasing prevalence, the underlying pathogenic mechanisms remain poorly understood, limiting development effective therapeutic interventions. We employed an untargeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from 78 SFTS patients during acute phase their illness. Differential metabolic...
Background/Objectives: Severe fever with thrombocytopenia syndrome (SFTS) is a viral infection primarily found in Asia, case fatality rate of about 10%. Despite its increasing prevalence, the underlying pathogenic mechanisms remain poorly understood, limiting development effective therapeutic interventions. Methods: We employed an untargeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) to analyze serum samples from 78 SFTS patients during acute phase their...
Myocardial infarction (MI) is one of the diseases with high fatality rate. Berberine (BBR) a monomer compound various biological functions. And some studies have confirmed that BBR plays an important role in alleviating cardiomyocyte injury after MI. However, specific mechanism unclear. In this study, we induced model MI by ligation left anterior descending coronary artery and surprisingly found significantly improved ventricular remodeling, minor inflammatory oxidative stress injury,...
Abstract Background In December 2019, a novel coronavirus (SARS-CoV-2) caused infectious disease, termed COVID-19, outbroke in Wuhan, China. COVID-19 patients manifested as lung injury with complications other organs, such liver, heart, gastrointestinal tract, especially for severe cases. However, whether causes significant acute kidney (AKI) remained controversial. Methods We retrospectively analyzed the clinical characteristics, urine and blood routine tests laboratory parameters of...
Objectives: COVID-19 emerged and rapidly spread throughout the world. Testing strategies focussing on patients with require assays that are high-throughput, low-risk of infection, small sample volumes. Antigen surveillance can be used to identify exposure pathogens measure acute infections. Methods: A total 914 serum samples, collected from 309 currently infected patients, 48 recovered ones, 410 non-COVID-19 were N protein antigen levels by a chemilumineseent immunoassay. Diagnostic...
Abstract The abnormality of immune regulation plays a critical role in the pathogenesis cancer; underlying mechanism has not been fully understood yet. This study aims to investigate cancer specific T helper (Th)2 response inhibition colon (Cca) cell growth. results showed that with Cca (CT26 cell) extracts as an antigen, Cca-extract Th2 was induced Cca-bearing mice. mass size significantly reduced, or radically disappeared (5 out 10; 50%); survival rate markedly improved mice immunized...
It is well-known that Dendritic cells (DCs) are essential in the development of airway Th2 polarization and allergy (AA). The underlying mechanism still not fully understood. objective this study to examine role methyltransferase-like protein-5 (Mettl5), a methyltransferase involved N6-methyladenosine (m6A) methylation, altering DC's properties facilitate AA. Dust mite extracts (DME) were used as specific antigen establish an AA mouse model. epigenetic status DCs was examined using Chromatin...
Background: In December 2019, a novel coronavirus (SARS-CoV-2) caused infectious disease, termed COVID-19, outbroke in Wuhan, China. COVID-19 patients manifested as lung injury with complications other organs, such liver, heart, gastrointestinal tract, especially for severe cases. However, whether causes significant acute kidney (AKI) remained controversial. Methods: We retrospectively analyzed the clinical characteristics, urine and blood routine tests laboratory parameters of hospitalized...
Rationale: Corticosteroid resistance (CR) seriously affects the therapeutic effects of steroids on many chronic inflammatory disorders, including airway allergy.The mechanism CR development is unclear.Recent research indicates that livin, an apoptosis inhibitor, associated with regulation in cell activities.This study investigates role livin inducing and sustaining mucosa.Methods: Nasal epithelial cells (NECs) were isolated from surgically removed nasal mucosal tissues patients allergic...
Background T‐helper 2 (Th2) polarization plays a critical role in the pathogenesis of chronic rhinosinusitis (CRS) with accompanying nasal allergy. Recent studies indicate that B cell lymphoma‐2‐like protein‐12 (Bcl2L12) is associated immune dysregulation. The purpose this study was to elucidate Bcl2L12 Th2 CRS patients. Methods patients allergy (CRSa) and without (CRSna) were recruited into study. CD4 + T cells isolated from blood samples human subjects. A variety immunologic molecular...
Introduction: Ulcerative colitis (UC) is a refractory disease with complex pathogenesis, and its pathogenesis not clear. The present study aimed to investigate the potential target related mechanism of Compound Sophora Decoction (CSD) in treating UC. Methods: A network pharmacology approach predicted components targets CSD treat UC, cell animal experiments confirmed findings new for treatment Results: total 155 were identified some macrophage polarization, such as nitric oxide synthase...
Abstract DNA quality is of paramount importance for molecular biology research. This study aimed to assess the extracted from residual blood clots after serological testing, focusing on impact clot segments, extraction kits, temporary storage durations (TSDs), and thawing methods quality. We divided column (BCC) healthy donors into three segments utilized two different kits. The BCCs were subjected four TSDs at 4°C (7 days, 10 1 month, 2 months) (4°C, room temperature, 37°C). found that...
Serosurveillance is crucial in estimating the range of SARS-CoV-2 infections, predicting possibility another wave, and deciding on a vaccination strategy. To understand herd immunity after COVID-19 pandemic, seroprevalence was measured 3062 individuals with or without from clinic.The levels antibody IgM IgG were by immuno-colloidal gold method. A fusion fragment nucleocapsid spike protein detected qualitative test kit sensitivity (89%) specificity (98%).The rate for all outpatients 2.81%...