A5033307656- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Dermatological and COVID-19 studies
- Extracellular vesicles in disease
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Medicinal Plants and Bioactive Compounds
- Mesenchymal stem cell research
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- interferon and immune responses
- Parvovirus B19 Infection Studies
- Estrogen and related hormone effects
- Hip disorders and treatments
- Pharmacological Effects of Natural Compounds
- Osteoarthritis Treatment and Mechanisms
- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Medicinal Plant Pharmacodynamics Research
- Orthopedic Infections and Treatments
- Barrier Structure and Function Studies
Huazhong University of Science and Technology
2008-2024
Union Hospital
2013-2024
Union Hospital
2008-2010
Huazhong University of Science and Technology Hospital
2009
Macrophage polarization is closely associated with the pathogenesis of ulcerative colitis (UC). Quercetin, a flavonoid, has shown promise as treatment for inflammatory diseases, but its specific mechanism action remains unclear. This study investigates whether quercetin can regulate intestinal macrophage and promote tissue repair via cGAS-STING pathway UC. In vivo , mice 3% DSS-induced UC were intraperitoneally injected RU.521 7 days, following which their general conditions corresponding...
Ulcerative colitis (UC) is an inflammatory disease with a complex pathogenic mechanism. Mounting evidence suggests that UC pathogenesis linked to excessive production of reactive oxygen species (ROS) and cellular DNA damage. Recent studies have shown bone mesenchymal stem cells (BMSCs) mainly exert their therapeutic effects through paracrine exosomes, concentration extremely important BMSCs exosomes. The main objective this study was determine whether exosomes from under hypoxic conditions...
Taraxasterol (TAX), one of the active components in Dandelion, demonstrated strong antitumor properties several cancers. However, effect and underlying mechanism TAX non-small cell lung cancer (NSCLC) is unclear. In this study, we showed that inhibited proliferation cells by inducing S-phase cycle arrest prevented migration interfering epithelial-mesenchymal transition (EMT) Lewis (LLC) carcinoma SPC-A1 cells. The pharmacological network analysis predicted induction apoptosis might be...
Abstract: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulcer formation of the intestinal mucosa. Due to its high recurrence rate, prolonged course, limited curative options, significant impact on patients' quality life, along with notable potential for malignant transformation, UC designated as refractory global health challenge World Health Organization (WHO). The elucidation pathogenesis therapeutic strategies requires...
Objective . To demonstrate the role of Wnt/ β -catenin canonical pathway in postmenopausal osteoporosis by evaluating serum levels patients with and analyzing their possible relationship OPG, RANKL, ratio RANKL/OPG, sclerostin, bone turnover markers. Methods 480 170 healthy women were enrolled study. Serum -catenin, sclerostin measured enzyme-linked immunosorbent assay. Bone status was assessed measuring mineral density Estradiol also detected. Results lower osteoporotic compared to...
Purpose/Objective Prompted by preliminary findings, this study was conducted to investigate the impact of zoledronic acid on cancellous bone microstructure and its effect level β-catenin in a mouse model postmenopausal osteoporosis. Methods Materials 96 8-week-old specific-pathogen-free C57BL/6 mice were randomly divided into 4 groups (24 per group): sham group, an ovariectomized osteoporosis estradiol-treated acid-treated group. Five months after surgery, third lumbar vertebra left femur...
Objective. To examine whether plasma adiponectin level is correlated with osteonecrosis of the femoral head (ONFH). Methods. Blood in patients nontraumatic ONFH (n = 120) was compared a group healthy subjects 120). Patients hip osteoarthritis (OA; n 30) and traumatic 45) were included as controls. Potential compounding factors, such low-density lipoprotein (LDL), high-density (HDL), apolipoprotein A1 (apo A1), B B), total cholesterol (TC), triglycerides (TG), C-reactive protein (CRP) also...
Qing'e formula (QEF), prepared from an ancient Chinese recipe, was previously suggested to regulate bone metabolism and improve mineral density in patients with osteoporosis. To study the effects of medicated serum containing QEF on vitro differentiation marrow-derived mesenchymal stem cells (BMSCs) isolated proximal femurs postmenopausal osteoporosis (PMOP) mice.Using established mouse model PMOP, mononuclear were marrow present cultured. PMOP mice also randomly divided into four groups:...
Background Sclerostin, expressed exclusively by osteocytes, is a negative regulator of bone formation. To gain insights into the action sclerostin in postmenopausal osteoporosis, we evaluated serum levels women and investigated its possible associations with turnover markers patients osteoporosis. Methods We detected sclerostin, measured lumbar spine mineral density 650 Chinese women. also assessed β-isomerized C-terminal crosslinking type I collagen, intact N-terminal propeptide N-mid...
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that greatly affects the health and life quality of elderly population. Existing drugs mainly alleviate symptoms but fail to halt disease progression, underscoring urgent need for development novel drugs. Based on neuroprotective effects flavonoid quercetin in AD, this study was designed identify potential AD-related targets perform
Active vitamin D is closely related to the circulating renin-angiotensin system (RAS) in experimental animal models and humans; however, corresponding local bone data remain limited. The present study examined whether 1,25-dihydroxyvitamin D3 supplementation altered RAS elements a murine model of glucocorticoid-induced osteoporosis (GIOP). A total 36 8-week-old mice were randomized into three equal-sized groups: sham, GIOP treatment groups. After 12 weeks, cancellous microstructure third...
Increased evidence indicating ghrelin's direct influence on bone has been reported, but previous studies did not investigate its relationship with osteonecrosis of the femoral head (ONFH) in vivo. Coagulation disorders are considered to play important roles ONFH. The aim this study was ghrelin, von Willebrand Factor (vWF) and other potentially relevant indicators non-traumatic head.Patients ONFH (including steroid-induced, alcohol-induced, idiopathic ONFH) healthy controls were recruited for...
Objectives: To study the partial mechanism of treating postmenopausal osteoporosis patients (POPs) using ancient recipe Qing'E Formula (QEF) by observing its effects on bone metabolic markers and VDR mRNA expression in primary POPs. Methods: Analysis was performed 120 outpatient inpatient POPs treated our hospital between January October 2013, where were randomly divided into group (QEF + Caltrate), Calcitriol (Caltrate soft capsules), Compare (Caltrate), each with a follow-up period 1 year....
Objective Increased evidence indicating ghrelin's direct influence on bone has been reported, but previous studies did not investigate its relationship with osteonecrosis of the femoral head (ONFH) in vivo. Coagulation disorders are considered to play important roles ONFH. The aim this study was ghrelin, von Willebrand Factor (vWF) and other potentially relevant indicators non-traumatic head. Methods Patients ONFH (including steroid-induced, alcohol-induced, idiopathic ONFH) healthy controls...
To investigate the differential expression of exosomal miRNAs in bone marrow tissue Modified Qing' E Formula (MQEF) on steroid-induced ischemic necrosis femoral head (INFH) model.Steroid hormones were used to establish INFH model and treated with MQEF. After successful modeling, exosomes isolated for miRNA sequencing obtain miRNAs. By GO analysis KEGG genes both groups, major MQEF exerting anti-INFH as well signaling pathways identified. Next, a quantitative metabolomic validation broad...
To explore whether the modified Qing' e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis.Network pharmacology was used to assess MQEP has a pro-angiogenic capacity predict its potential targets. Human umbilical vein endothelial cells were treated with glucocorticoids cell viability. The expression of angiotensin II type 1 receptor, 2 converting enzyme, which are associated activation renin-angiotensin-aldosterone system, vascular growth factor...