A5101668814- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Advanced Photonic Communication Systems
- Optical Network Technologies
- Biological and pharmacological studies of plants
- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Natural Compounds in Disease Treatment
- Ginger and Zingiberaceae research
- Web Data Mining and Analysis
- Chemotherapy-induced organ toxicity mitigation
- Alcohol Consumption and Health Effects
- Histone Deacetylase Inhibitors Research
- Advanced Sensor and Control Systems
- Advanced Malware Detection Techniques
- Spam and Phishing Detection
- PAPR reduction in OFDM
- Pharmacological Effects of Natural Compounds
- Water Quality Monitoring and Analysis
- Ginseng Biological Effects and Applications
- Network Security and Intrusion Detection
- High-Temperature Coating Behaviors
- Immune cells in cancer
- Immune Response and Inflammation
Huazhong University of Science and Technology
2015-2024
Zhejiang University of Technology
2013-2024
Shanghai Jiao Tong University
2021-2024
Renji Hospital
2021-2024
Tongji Hospital
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Gansu Provincial Hospital
2023
State Key Laboratory of Oncogene and Related Genes
2021-2023
Gansu University of Traditional Chinese Medicine
2023
Programmed death receptor-1 (PD-1) blockade shows little benefit in patients with microsatellite-stable colorectal cancer (MSS-CRC). Fruquintinib is a China-made anti-angiogenic drug which approved for the third line therapy mCRC. This study investigates effect of combination fruquintinib and PD-1 on MSS-CRC its relative mechanisms.The mouse allograft tumor models that represent MSS microsatellite instability (MSI) CRC were established using murine CT26 MC38 colon cells, respectively, to...
Abstract Multiple primary cancer (MPC) denotes individuals with two or more malignant tumors occurring simultaneously successively. Herein, a total of 11,000 pancancer patients in TCGA database (1993–2013) were divided into MPC non-MPC groups based on their history other tumors. The incidence has risen to 8.5–13.1% since 2000. Elderly individuals, males, early-stage patients, and African Americans Caucasians are identified as independent risk factors (p < 0.0001). Non-MPC exhibit...
Ethanol-induced gastric mucosal injury is a common gastrointestinal disorder. Polysaccharides separated from herbs have been shown to be effective for ethanol-induced injury, but whether the polysaccharides Dendrobium officinale Kimura & Migo leaves (LDOP-1) protected mucosa remains unknown. Thus, present study carried out protection and mechanism of LDOP-1 in vivo vitro. The chemical composition was heteropolysaccharide comprising mannose, galacturonic acid, glucose, galactose, arabinose at...
Abstract Metalloenzymes are attractive research targets in fields of chemistry, biology, and medicine. Given that metalloenzymes can manifest conservation metal-coordination ligand binding modes, the excavation expansion metalloenzyme-specific knowledge is interest bridging metalloenzyme-related fields. Building on our previous metalloenzyme-ligand association database, MeLAD, we have expanded scope services, by forming a versatile platform, termed Metalloenzyme Data Bank Analysis (MeDBA)....
Cancer-associated fibroblasts (CAFs) has been recognized as one cause of tumor resistance to immune checkpoint blockade therapy, but the underlying mechanisms still remain elusive. In present study, a bone marrow-derived CAF (BMF) -rich model is successfully established by subcutaneously mixed inoculation BMFs and cells into mice BMF-mixed xenografts are demonstrated be resistant anti-PD-L1 antibody immunotherapy compared mere xenografts. vitro assays via co-culture system indicate that...
Taraxasterol (TAX), one of the active components in Dandelion, demonstrated strong antitumor properties several cancers. However, effect and underlying mechanism TAX non-small cell lung cancer (NSCLC) is unclear. In this study, we showed that inhibited proliferation cells by inducing S-phase cycle arrest prevented migration interfering epithelial-mesenchymal transition (EMT) Lewis (LLC) carcinoma SPC-A1 cells. The pharmacological network analysis predicted induction apoptosis might be...
In order to establish the extraction technology of flavonoids from Dendrobium officinale leaves, a method combining Plackett–Burman design (PBD), steepest ascent design, and central composite was developed optimize flavonoids. addition, tyrosinase activity inhibition further tested in vitro. PBD results showed that ethanol concentration number extractions were key factors. Response surface methodology (RSM) indicated optimal conditions 78% concentration, six times, 2 h, 1:50 solid-liquid...
Abstract Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, its and mechanism colorectal cancer (CRC) remain to be studied. In this study, dramatically inhibited CRC cell proliferation (with 0.38 µg/ml, 0.77 µg/ml IC50 RKO HCT116, respectively) vitro. Immunofluorescence staining showed that induced the formation of bundling asters cells....
Oxide melt growth ceramics (OMGCs) exhibit excellent performance and microstructure stability near their melting point are expected to become a new structural material for long-term stable service in extremely high-temperature water-oxygen environments. Owing its unique advantages of high efficiency, flexible manufacturing, near-net shaping, laser directed energy deposition (LDED) has promising technology the rapid preparation high-performance OMGCs. However, owing limited understanding...
Objective: Tumor growth is one of the most lethal attributes human malignancy. The expression CCDC7, a novel gene which has multiple functions, been shown to be associated with tumor and poor prognosis in patients cancer. However, specific functions CCDC7 remain unclear. Here, we investigated molecular mechanisms underlying effects on proliferation cervical Materials Methods: MTT EdU assays were performed evaluate function CCDC7. immunohistochemical, quantitative real-time PCR (qRT-PCR),...
Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as treatment for insomnia more than thousand years. However, recent studies have found no significant effects of SZRT caused by gastric discomfort. Herein, we studied the modified (MSZRD) on gastrointestinal disorder-related insomnia. The main constituents MSZRD were spinosin (2.21 mg/g) and 6-feruloylspinosin (0.78 mg/g). A pentobarbital-induced animal model showed that shortened sleep latency prolonged time...
We propose a coherent optical OFDM (CO-OFDM) system based on 3-dimensional (3-D) technique in this paper. By using the 3-D signal mapper and 2-D IFFT module, minimum Euclidean distance (MED) constellations is increased by 8.7%, peak-to-average power ratio of generated reduced 4 dB. The experimental results show that method can improve nonlinearity tolerance 2 dB for 100-km standard single mode fiber 16.27-Gb/s without polarization modulation. Theoretical analysis simulation OSNR penalty...
Aim and Objective: Fructose, as a ubiquitous monosaccharide, can promote ATP consumption elevate circulating Uric acid (UA) levels. Our previous studies have confirmed that the macroporous resin extract of Dendrobium officinale leaves (DoMRE) could reduce UA level rats with hyperuricemia induced by high-purine diet. This study aimed to investigate whether DoMRE had UA-lowering effect on caused fructose combined potassium oxonate, so further clarify DoMRE, explore UAlowering both production...
Non-invasive prenatal diagnosis for single-gene disorders (NIPD) is still in development and deserves further study. The advent of next-generation sequencing technology significantly improved the detection multiple mutations non-invasive disorder purposes. However, bespoke amplicon-based NGS assays are costly. In this study, we developed a new strategy screening based on capillary electrophoresis (CE) platform using an amplification refractory mutation system (ARMS)-PCR technique....