A5054175249- Cancer-related molecular mechanisms research
- Congenital gastrointestinal and neural anomalies
- Circular RNAs in diseases
- Natural Compounds in Disease Treatment
- Supercapacitor Materials and Fabrication
- Advanced Numerical Methods in Computational Mathematics
- Advancements in Battery Materials
- Differential Equations and Numerical Methods
- Autoimmune and Inflammatory Disorders Research
- Ovarian function and disorders
- Congenital Anomalies and Fetal Surgery
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Rheumatoid Arthritis Research and Therapies
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Numerical methods for differential equations
- Autophagy in Disease and Therapy
- Computational Fluid Dynamics and Aerodynamics
- Drug Transport and Resistance Mechanisms
- Reproductive biology and impacts on aquatic species
- Catalytic Processes in Materials Science
- Healthcare Policy and Management
- Viral Infections and Immunology Research
- Medical Coding and Health Information
Huadong Hospital
2014-2025
Fudan University
2014-2025
Daping Hospital
2016-2025
Army Medical University
2016-2025
Nanjing Medical University
2016-2025
Huaian First People’s Hospital
2016-2025
Guangxi Medical University
2025
Sanya University
2024-2025
Hainan University
2024-2025
Anhui University of Science and Technology
2025
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Recent years, circular RNA (circRNA) have been shown to exert vital functions in pathological progressions many diseases. A growing number evidences identified representative function exosomal circRNAs physiological state donor cells, which further induces cellular responses after captured by recipient cells. However, contributions HCC remain largely unknown. In vitro and vivo regulatory roles circRNA Cdr1as...
Abstract Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric adult patients, respectively. Both exhibit significant heterogeneity, shaped by distinct genetic/epigenetic drivers, transcriptional programs including RNA splicing, microenvironmental cues glioma niches. However, spatial organization of cellular states niche-specific regulatory remain to be investigated. Here, we perform a profiling DMG GBM combining...
Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane...
Hospital crowding is a rising problem, effective predicting and detecting managment can helpful to reduce crowding. Our team has successfully proposed hybrid model combining both the autoregressive integrated moving average (ARIMA) nonlinear neural network (NARNN) models in schistosomiasis hand, foot, mouth disease forecasting study. In this paper, our aim explore application of ARIMA-NARNN track trends new admission inpatients, which provides methodological basis for reducing crowding.We...
Abstract Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis. Despite extensive efforts to characterize hNSCs end-stage GBM at bulk single-cell levels, the de novo gliomagenic path largely unknown due technical difficulties in early-stage sampling preclinical modeling. Here, we established two penetrant hNSC-derived malignant glioma models, which resemble histopathology...
Systemic Lupus Erythematosus (SLE) is a typical autoimmune disease characterized by complex pathogenesis and strong genetic predisposition. The study of inflammatory response in SLE monocytes not very clear, exploring the factors beneficial to discover new diagnostic targets. Using scRNA-seq technology, we obtained quantitative changes circulating immune cells various cellular metabolic profiles between patients healthy volunteers. A significant increase was observed peripheral blood...
Viruses with double-stranded RNA genomes form isometric particles or are capsidless. Here we report a virus, Colletotrichum camelliae filamentous virus 1 (CcFV-1) isolated from fungal pathogen, that forms particles. CcFV-1 has eight genomic RNAs, ranging 990 to 2444 bp, encoding 10 putative open reading frames, of which frame encodes an RNA-dependent polymerase and 4 capsid protein. When inoculated, the naked RNAs infectious induce accumulation in vivo. is phylogenetically related...
Background Outbreaks of hand-foot-mouth disease (HFMD) have been reported for many times in Asia during the last decades. This emerging has drawn worldwide attention and vigilance. Nowadays, prevention control HFMD become an imperative issue China. Early detection response will be helpful before it happening, using modern information technology epidemic. Method In this paper, a hybrid model combining seasonal auto-regressive integrated moving average (ARIMA) nonlinear neural network (NARNN)...
Abstract Objectives Emerged evidence demonstrates that long non‐coding RNA s (lnc s) may play quintessential regulatory roles in the cellular processes, tumourigenesis and development of disease. Though focally amplified lnc on chromosome 1 ( FAL 1) has been identified to have crucial functions many diseases, its biological mechanism Hirschsprung's disease HSCR ) still remains unknown. Materials methods The expression levels aganglionic tissues matched normal specimens were detected by...
Triptolide (TP), known for its effectiveness in treating various rheumatoid diseases, is also associated with significant hepatotoxicity risks. This study explored Catalpol (CAT), an iridoid glycoside antioxidative and anti-inflammatory effects, as a potential defense against TP-induced liver damage.
Brassica napus (B. napus) is susceptible to multiple abiotic stresses that can affect plant growth and development, ultimately reducing crop yields. In the past, many genes provide tolerance have been identified characterized. Peroxidase (POD) proteins, members of oxidoreductase enzyme family, play a critical role in protecting plants against stresses. This study demonstrated comprehensive investigation POD gene family B. napus. As result, total 109 were across 19 chromosomes classified into...