A5101423347- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Healthcare and Venom Research
- Clostridium difficile and Clostridium perfringens research
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Animal Disease Management and Epidemiology
- Vasculitis and related conditions
- Autophagy in Disease and Therapy
- Long-Term Effects of COVID-19
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Uterine Myomas and Treatments
- Hepatitis C virus research
- IgG4-Related and Inflammatory Diseases
- Chronic Kidney Disease and Diabetes
- Anesthesia and Neurotoxicity Research
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Viral gastroenteritis research and epidemiology
Huazhong University of Science and Technology
2018-2024
Union Hospital
2020-2024
Wuhan Children's Hospital
2022-2024
Baoding No.1 Central Hospital
2022-2023
Qingdao University
2005-2023
Qingdao Municipal Hospital
2005-2023
Union Hospital
2018-2023
Affiliated Hospital of Qingdao University
2023
Baoding People's Hospital
2022-2023
Harbin Medical University
2023
To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).A total 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms signs, laboratory findings, chest computed tomography (CT) as well treatment measures collected analysed.We found that without other comorbidities but (n = 24) at higher severe pneumonia, release tissue injury-related enzymes, excessive...
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colon, and it has become one world-recognized medical problems as recurrent refractory.Berberine (BBR) effective drug for UC treatment.However, underlying mechanism targets remain obscure.In this study, we systematically investigated therapeutic effect its BBR in ameliorating DSS-induced mouse colitis.Expectedly, colon inflammation was significantly relieved by BBR, microbiota depletion antibiotic cocktail...
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induced Disease 2019 (COVID-19) has posed a global threat to public health. The immune system is crucial in defending and eliminating the virus infected cells. However, dysregulation may result rapid progression of COVID-19. Here, we evaluated subsets, phenotypic functional characteristics natural killer (NK) T cells patients with COVID-19 their associations disease severity. Methods: Demographic clinical data enrolled...
Highlights•The COVID-19 patients with CVD experienced more severe pneumonia.•The showed tissue injury-related enzymes release.•The were at higher risk of cytokine storm.•The hypercoagulable state.•CVD is a factor for the progression and prognosis COVID-19.AbstractBackground aimA novel coronavirus acute respiratory syndrome corona virus 2 (SARS-CoV-2) caused pneumonia, Coronavirus Disease 2019 (COVID-19), broke out in Wuhan, China December 2019, spread all over world. Patients huge...
An outbreak of pneumonia caused by a novel coronavirus (COVID-19) began in Wuhan, China December 2019 and quickly spread throughout the country world. efficient convenient method based on clinical characteristics was needed to evaluate potential deterioration patients. We aimed develop simple practical risk scoring system predict severity COVID-19 patients admission. retrospectively investigated information confirmed from 10 February 2020 29 Wuhan Union Hospital. Predictors were identified...
Commensal gut microbiota protects the immune defense of extra-intestinal organs. Gut depletion by antibiotics can impair host antiviral responses and alter hepatitis B virus (HBV) infection outcomes. However, how modulates response in liver remains unclear. Here, mice were treated with broad-spectrum to deplete microbiota. integrity was evaluated, translocation live commensal bacteria their components into investigated. An HBV model established evaluate impairment after depletion. We found...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by many factors including colonic inflammation and microbiota dysbiosis. Previous studies have indicated that celastrol (CSR) has strong anti-inflammatory immune-inhibitory effects. Here, we investigated the effects of CSR on mucosal immunity in an experimental model, addressed mechanism which exerts protective We characterized therapeutic potential treating UC using histological staining, intestinal permeability assay,...
Aloperine (ALO), a quinolizidine-type alkaloid isolated from natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive. Here, it is demonstrated that ALO inhibits the proliferation migration non-small cell lung cancer lines in vitro tumor development several mouse models vivo. Mechanistically, fusion autophagosomes with lysosomes autophagic flux, leading to accumulation sequestosome-1 (SQSTM1) production...
Gut microbiota composition is known to be associated with the progression of hepatitis B virus (HBV)-related liver cirrhosis in humans, outcome HBV infection mice, and seroconversion e-antigen nucleot(s)ide analog-treated patients. The dynamic alteration gut following still unknown. In this study, a hydrodynamic injection mouse model mimicking acute or chronic humans comparable virological immunological features was used. control mice analyzed at different time points using Illumina MiSeq...
Streptococcus suis serotype 2 is an important zoonotic pathogen causing severe infections in pigs and humans. The pathogenesis of S. infections, however, still poorly understood. Spx proteins are a group global regulators involved stress tolerance virulence. In this study, we characterized two orthologs the regulator, SpxA1 SpxA2 2. Two mutant strains (ΔspxA1 ΔspxA2) lacking spx genes were constructed. ΔspxA1 ΔspxA2 mutants displayed different phenotypes. exhibited impaired growth presence...
Background: Last winter, a new coronavirus-induced pneumonia, COVID-19, broke out in Wuhan, China, and spread rapidly throughout the country due to its high infectivity. Although several researches on clinical characteristics have been published, indicators dynamic changes during disease progression are still not clear need be further explored.Methods: We retrospectively studied 165 patients with COVID-19 who were admitted five hospitals outside Wuhan from January 2 February 5, 2020....
Taraxasterol (TAX), one of the active components in Dandelion, demonstrated strong antitumor properties several cancers. However, effect and underlying mechanism TAX non-small cell lung cancer (NSCLC) is unclear. In this study, we showed that inhibited proliferation cells by inducing S-phase cycle arrest prevented migration interfering epithelial-mesenchymal transition (EMT) Lewis (LLC) carcinoma SPC-A1 cells. The pharmacological network analysis predicted induction apoptosis might be...
In carcinogenesis, inflammasomes may play contradictory roles through facilitating anti-tumor immunity or inducing oncogenic factors. Their function in cancer remains poorly characterized. this study, we explored the effect of interleukin-17A (IL-17A) on migration and invasion activity nasopharyngeal carcinoma (NPC) cell lines account for related mechanisms. Our results revealed that exogenous IL-17A promoted significantly both NPC-039 CNE-2Z lines. addition, expression matrix...
Background: Subcellular expression of P-glycoprotein (P-gp) may play an essential role in multidrug resistance (MDR) many cancers. However, the mitochondria and functional activity P-gp ovarian cancer are still unclear. In this study, we isolated from A2780 cell line its paclitaxel-resistant subline A2780T investigated function P-gp. Methods: Immunocytochemistry was used to evaluate subcellular localization cells. Immunofluorescence laser confocal microscopy were detect co-localization both...
Abstract Background In December 2019, a novel coronavirus (SARS-CoV-2) caused infectious disease, termed COVID-19, outbroke in Wuhan, China. COVID-19 patients manifested as lung injury with complications other organs, such liver, heart, gastrointestinal tract, especially for severe cases. However, whether causes significant acute kidney (AKI) remained controversial. Methods We retrospectively analyzed the clinical characteristics, urine and blood routine tests laboratory parameters of...
The susceptibility of mice to hepatitis B virus (HBV) infection depends on their genetic background. gut microbiota modulates the antiviral immune response in liver and plays a protective role against HBV infection. However, whether outcomes depend remains unclear. In this study, we assessed composition naïve BALB/c C57BL/6 using 16S rRNA gene sequencing. was depleted broad-spectrum antibiotics (ABX) then reconstituted with fecal from or evaluate effect transplantation (FMT) We found that...
Epidemiological investigations of the relationship between oral contraceptives and rheumatoid arthritis (RA) risk have reported controversial results. Therefore, a meta-analysis case-control or cohort studies was performed to evaluate role in relation developing RA.Eligible were identified from databases PubMed EMBASE by searching reviewing references. Random effect models utilized summarize relative (RR) estimates with 95% confidence intervals (CIs).A total 12 five eligible for our...
Abstract The persistent public health threat of animal to human transmission influenza A virus (IAV) has stimulated interest in rapid and accurate detection all IAV subtypes clinical specimens origin. In this study, a new set primers probes was designed for one-step pan-IAV reverse-transcription fluorescence resonance energy transfer (FRET)-PCR. limit RT FRET-PCR 10 copies the matrix gene per reaction proved be equivalent or superior isolation detecting nine subtypes. Application...
After strabismus surgery, the local swelling of conjunctival wound will affect uniform distribution tears on ocular surface, and inflammatory reaction stability tear film, which easily lead to iatrogenic dry eye. This study aimed investigate effect vitamin A palmitate (VAP) eye gel application in advantages Watson's theory caring.Two hundred forty children with after surgery treated our hospital from September 2018 2020 were selected as subjects, randomly divided into control group...
Background:Endoscopic submucosal dissection (ESD) has become a preferred treatment method for patients with early esophageal cancer (EEC), but it can easily be complicated by stricture.In this study, we aimed to analyze the predictive value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) post-ESD stricture EEC. Material/Methods:A retrospective study 285 EEC who underwent ESD was conducted.Patients were divided into 2 groups according...