A5083141635- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Streptococcal Infections and Treatments
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Listeria monocytogenes in Food Safety
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Plant Pathogenic Bacteria Studies
- Genetic and phenotypic traits in livestock
- Salmonella and Campylobacter epidemiology
- Antimicrobial Resistance in Staphylococcus
- Lung Cancer Research Studies
- Photosynthetic Processes and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dermatology and Skin Diseases
- Plant biochemistry and biosynthesis
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2025
Guizhou University
2022-2025
Institute of Laboratory Animal Science
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Chengdu Normal University
2025
Nanjing University
2023-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Zhejiang A & F University
2021-2024
Polytechnic University
2024
Abstract Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples primary tumors and axillary nodes. We identified nine cell subclusters including CD44 + / ALDH2 /ALDH6A1 stem (BCSCs), which had a copy-number variants similar to that normal tissue. Importantly, BCSCs existed only in evolved into metastatic clusters infiltrating Furthermore, data...
Abstract Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but only in a fraction of patients with hepatocellular carcinoma (HCC). cell 1 ligand (PD-L1) binds to its receptor PD1 on T cells dampen antigen-tumor immune responses. However, the mechanisms underlying PD-L1 regulation are not fully elucidated. Herein, we identify that tumoral Prdm1 overexpression inhibits growth immune-deficient mouse models. Further, upregulates levels, dampening anti-tumor immunity vivo,...
Diosgenin saponins isolated from Dioscorea species such as D. zingiberensis exhibit a broad spectrum of pharmacological activities. Diosgenin, the aglycone diosgenin saponins, is an important starting material for production steroidal drugs. However, how plants produce and origin evolution saponin biosynthetic pathway remain mystery. Here we report high-quality, 629-Mb genome anchored on 10 chromosomes with 30 322 protein-coding genes. We reveal that synthesized in leaves ('source'), then...
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes is implicated the pathogenesis of IBD CRC. Circular RNAs (circRNAs) have gained attention for roles various diseases, including However, comprehensive understanding specific circRNAs involved CRC, functional...
Purpose: Breast cancer (BC) and lung are the most two common cancers with highest morbidity mortality for women. With prolonged survival, there comes possibility that BC patients will develop second primary cancers. We evaluate characteristics, incidence survival of non-small cell (BC-NSCLC) small (BC-SCLC) after breast cancer. Patients methods: Second risks using standardized ratios (SIRs) [95% confidence intervals (95% CIs)] were calculated among in SEER-18 (2000-2014). Survival outcomes...
Abstract Objectives To investigate the function and regulatory mechanism of Krüppel‐like factor 3 (KLF3) in lung cancer. Materials Methods KLF3 expression was analysed by qRT‐PCR Western blot assays. The proliferation, migration, invasion, cycle apoptosis were measured CCK‐8 EdU, wound‐healing Transwell, flow cytometry tumour growth detected nude mouse tumorigenesis assay. In addition, interaction between Sp1 accessed luciferase reporter, EMSA ChIP JAK2, STAT3, PI3K p‐AKT levels evaluated...
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, considerable attention has been paid on its epidemiology and clinical characteristics children patients. However, it is also crucial for clinicians to summarize investigate co-infection SARS-CoV-2 children. We retrospectively reviewed manifestations, laboratory findings, imaging COVID-19 patients group (CI, n = 27) single infection (SI, 54). Samples were tested multiple pathogens. A high incidence (27/81, 33%) with...
This study aimed to identify polymorphisms in the gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase 1, HMGCS1, and analyze their association with slaughter characteristics, meat quality, organ coefficients Guizhou white goats. A total of 153 twelve-month-old goats (78 male 75 female) were included study. Slaughter assessed. Association analyses between genotypes phenotypic traits conducted using a generalized linear model. Four polymorphic loci identified, i.e., g.15523T>C, g.15530G>C,...
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major challenge in the treatment of lung cancer. Cancer associated fibroblasts (CAFs) play key role promoting anti-cancer therapies. This study identified subpopulation CAFs characterized by overexpression collagen triple helix repeat-containing 1 (CTHRC1) through single-cell RNA sequencing cancer patients undergoing EGFR-TKI treatment. These CTHRC1+ were enriched drug-resistant tumors....
Abstract Despite the progress of treatment in gastric cancer (GC), overall outcomes remain poor patients with advanced diseases, underscoring urgency to develop more effective strategies. BH3-mimetic drugs, which inhibit pro-survival BCL2 family proteins, have demonstrated great therapeutic potential therapy. Although previous studies implicated a role targeting cell survival pathway GC, contribution different proteins promoting and mediating resistance current standard therapies GC remains...
Congenital pulmonary airway malformation (CPAM) belongs to rare lung abnormalities which may result in poor development outcomes. However, the etiology of CPAM has not been well described. In this study, whole-exome sequencing (WES) technology was used sequence 9 families screen pathogenic genes and their mutations for CPAM. Sanger performed verify functions these mutations. We found compound heterozygous OBSCN gene two patients with CPAM: one p.G8837A mutation inherited from her father...
Abstract Background The regulation of protein phosphorylation requires a balance in the activity kinases and phosphatases. Our previous data indicates that Src can increase ERK through Raf kinase response to ischemic stimuli. This study examined molecular mechanisms by which activates cascade phosphatases following cerebral ischemia. Results Ischemia-induced activation is followed PP2A at Tyr307 leading its inhibition rat hippocampus. SU6656, inhibitor, up-regulates activity, resulting...
Raddeanin A is one of the triterpenoid saponins in herbal medicine Anemone raddeana Regel which was reported to suppress growth liver and lung cancer cells. However, little known about its effect on gastric (GC) This study aimed investigate inhibitory three kinds different differentiation stage GC cells (BGC-823, SGC-7901 MKN-28) vitro possible mechanisms. Proliferation assay flow cytometry demonstrated A's dose-dependent determined induction apoptosis, respectively. Transwell assay,...
Urban particulate matter (PM) contributes to the increasing number of people with asthma, which is closely related development industrialization. Especially, PM an aerodynamic diameter <2.5 µm (PM2.5) enhances risk damaging respiratory organs. It has reported that PM2.5-induced pathological changes could be considered as a remarkable molecular mechanism PM2.5-mediated cytotoxicity in disease and even lung cancer.In this study, we have investigated effects PM2.5 on ovalbumin (OVA)-induced...
Background: There has been evidence that Polybromo-1 (PBRM1) mutation was closely associated with immunotherapy response in clear cell renal carcinoma (ccRCC). However, it remains incompletely unclear whether PBRM1 mutations correlate ICI pan-cancer. Methods: The clinical data and whole exome sequencing (WES) were collected from seven published studies to evaluate the association between ICIs efficacy discovery cohort. In order provide further insight into relationship immunity, we analyzed...