A5005577232- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Genetic and phenotypic traits in livestock
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
Nanjing University of Chinese Medicine
2016-2025
Jiangsu Province Hospital
2016-2025
Shanghai Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Hunan University of Traditional Chinese Medicine
2022-2024
Guizhou University
2023
Weatherford College
2020
Nanjing University
2009-2017
Nanjing Drum Tower Hospital
2010-2016
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2015
Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as depression and anxiety. Gut microbiota imbalance disturbed metabolism been suggested to play an important role in either UC or disorders. However, little is known about their detailed multi-omics characteristics patients depression/anxiety. In this prospective observational study, 240 Chinese were enrolled, including 129 active (69 Phase 1 60 2; divided into depression/non-depression anxiety/non-anxiety...
Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), composition, mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in disruption mucus, aggravation colitis. In addition, abundance Akkermansia muciniphila was significantly decreased UC patients depression, positively...
Alzheimer's disease (AD), an age-associated neurodegenerative disorder, currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds promising potential in AD treatment, exemplified by Danggui Shaoyao San (DSS), a TCM formulation. The precise therapeutic mechanisms of DSS remain to be fully elucidated. This study aims uncover the efficacy and underlying AD, employing integrative approach encompassing gut microbiota metabolomic analyses.
Wumei Wan (WMW), a traditional Chinese medicine prescription, has been proved to be effective in treating Colitis-associated colorectal cancer (CAC), but it not proven different stages of CAC.
Colorectal cancer pathogenesis remains incompletely understood. Here, we report that the heterochromatin protein HP1γ is upregulated commonly in human colorectal cancer, where it promotes cell proliferation vitro and vivo. Gene-expression promoter-binding experiments demonstrated directly regulated CDKN1A (p21(Waf1/Cip1)) a manner associated with methylation of histone H3K9 on its promoter. We identified miR-30a as tumor-suppressive microRNA targets vivo to specifically suppress growth mouse...
The present study assessed the antitumor effect of artesunate (ART) in vitro and vivo, as well its underlying mechanism action HCT116 colon cancer cells. An MTT assay, DAPI staining, flow cytometry, western blotting, immunohistochemistry, transmission electron microscopy TUNEL assay were performed to molecular effects ART was observed inhibit proliferation by inducing apoptosis cells both vivo. Flow cytometry analysis demonstrated that treatment with 2 4 µg/ml for 48 h induced early 22.7...
// Jin-Yong Zhou 1, * , Min Chen 2, Long Ma 3, Xiaoxiao Wang 4 Yu-Gen 5, Shen-Lin Liu 6 1 Central Laboratory, The Affiliated Hospital of Nanjing University Chinese Medicine, Jiangsu Province Traditional Nanjing, China 2 Department Internal 3 Urology, Medical Science Research, 5 Colorectal Surgery, Oncology, These authors contributed equally to this work Correspondence to: Liu, e-mail: jsszyylsl@163.com Keywords: CD133, CD44, cancer stem cells (CSCs), colorectal cancer, biomarkers Received:...
Post inflammatory irritable bowel syndrome (PI-IBS), a subset of IBS, is characterized by symptoms visceral pain, bloating, and changed habits that occur post initial episode intestinal infection. Gut microbial dysbiosis or inflammation plays key role in the pathogenesis abdominal hypersensitivity PI-IBS. Electroacupuncture (EA) stimulation results an alleviated PI-IBS-associated symptom. This study investigated effect EA on IL-18 gut one hypersensitive rat models with A trinitrobenzene...
Colorectal cancer (CRC) has a high incidence and mortality rate worldwide. Colitis-associated CRC (CAC) is used for describing the relationship between inflammation CRC. No chemopreventive agents have been found to be both effective safe in Therefore, prevention treatment of CAC are extremely urgent. Wu Mei Wan (WMW) clinical enteritis with remarkable efficacy. Here, we aim investigate underlying mechanism WMW CAC. The AOM/DSS-induced mouse model was used, mice were divided into normal...
poorly cohesive (PC) gastric cancer (GC) (PC-GC) is a distinct histological subtype of GC and defined as tumor consisting isolated or small clusters cells with differentiated metastatic characteristics. According to multiple studies, PC-GC intrinsically heterogeneous, mesenchymal variants being the most aggressive. However, date, molecular mechanisms associated are still not fully understood. This study investigated role USP51/ZEB1/ACTA2 axis in promoting metastasis. Single-cell sequencing...
Colorectal cancer has become one of the leading cause morbidity and mortality throughout world. Hederagenin, a derivative oleanolic acid isolated from leaves ivy (Hedera helix L.), been shown to have potential anti-tumor activity. The study was conducted evaluate whether hederagenin could induce apoptosis human colon LoVo cells explore possible mechanism. MTT assay used for evaluating cell viability while Annexin V-FITC/PI Hoechst 33342 nuclear stainining were determination mitochondrial...
P. polyphylla Smith var. chinensis (Franch.) Hara (PPSCFH) has been used as medicinal Paris for the prevention and treatment of cancers in China thousands years. Its main components, steroidal saponins (PRS), have confirmed to inhibit tumor growth. In present study, immunostimulation PRS was investigated Lewis bearing-C57BL/6 mice while induction apoptosis A549 cells also studied. The with (2.5, 5.0 7.5 mg/kg) significantly inhibited tumor, volume, weight C57BL/6 mice. rates inhibition (at...
Raddeanin A is one of the triterpenoid saponins in herbal medicine Anemone raddeana Regel which was reported to suppress growth liver and lung cancer cells. However, little known about its effect on gastric (GC) This study aimed investigate inhibitory three kinds different differentiation stage GC cells (BGC-823, SGC-7901 MKN-28) vitro possible mechanisms. Proliferation assay flow cytometry demonstrated A's dose-dependent determined induction apoptosis, respectively. Transwell assay,...
Solasodine is a main active component isolated from Solanum incanum L. that performs wide range of functions containing anti‐oxidant, anti‐infection, and neurogenesis promotion. In this study, we explored the influence solasodine on three types human colorectal cancer ( CRC ) cell lines. The results show prohibited proliferation dose‐ time‐dependently impeded motility by downregulating MMP s. was also found to fuel caspase‐cascade reaction increase ratio between Bax Bcl‐2 so as induce...
The modified Si-Jun-Zi Decoction (SJZ), a Chinese medicine formula, is clinically used against multiple malignancies including colorectal cancer (CRC). This study aims to evaluate the effect of SJZ on CRC liver metastasis and identify therapeutic mechanisms.Human cells with GFP fluorescence were transplanted into Balb/c nude mice spleens. Modified SJZ, 5-fluorouracil or combined treatment was given for 3 weeks. measured by imaging plasma cytokines analyzed. Furthermore, effects...
Raddeanin A (RA) is an extractive from Anemone raddeana Regel , a traditional Chinese medicine. The aim of this study to assess the efficacy RA against human gastric cancer (GC) cells (SGC-7901) and explore its mechanism. MTT assay showed that inhibition proliferation SGC-7901 increased in dose-dependent manner. Flow cytometry analysis Hoechst 33258 staining induced apoptosis on cells. Meanwhile, it autophagy. Western blotting induces autophagy by activating p38 MAPK pathway inhibiting mTOR...
To observe the inhibitory effect and potential mechanism of Yiqi Huayu Jiedu Decoction (YHJD) on liver metastasis colorectal cancer (CRC). We compared changes weight index before after YHJD treatment in CRC mouse models. HE staining was employed to pathological tissue sections. Flow cytometry used analyze number marker neutrophils treated with YHJD. Transcriptomics, proteomics, multiplex cytokine array analyses were conducted further verify role CXCL1. Differential gene analysis performed...