A5055196800- Gut microbiota and health
- Genetic Associations and Epidemiology
- Medicinal Plants and Bioactive Compounds
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Cancer Mechanisms and Therapy
- Medical Research and Treatments
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- COVID-19 epidemiological studies
- Visual perception and processing mechanisms
- COVID-19 Pandemic Impacts
- Bioinformatics and Genomic Networks
- Clostridium difficile and Clostridium perfringens research
- Ferroptosis and cancer prognosis
- Tryptophan and brain disorders
- Action Observation and Synchronization
- Memory Processes and Influences
- Regional Development and Environment
- Nuclear Structure and Function
- Cognitive Functions and Memory
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Mesenchymal stem cell research
- Polymer-Based Agricultural Enhancements
Nanjing University of Chinese Medicine
2018-2025
Jiangsu Province Hospital
2018-2025
Second Affiliated Hospital of Jilin University
2023-2024
Jinhua Polytechnic
2022
First Hospital of Jilin University
2021
Jilin University
2021
Chinese Medical Center
2020
Chinese Institute for Brain Research
2018-2020
Peking University
1994-2020
Center for Life Sciences
2016-2020
Abstract The novel coronavirus (SARS-CoV-2/2019-nCoV) identified in Wuhan, China, December 2019 has caused great damage to public health and economy worldwide with over 140,000 infected cases up date. Previous research suggested an involvement of meteorological conditions the spread droplet-mediated viral diseases, such as influenza. However, for recent coronavirus, few studies have discussed systematically about role daily weather epidemic transmission virus. Here, we examine relationships...
Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as depression and anxiety. Gut microbiota imbalance disturbed metabolism been suggested to play an important role in either UC or disorders. However, little is known about their detailed multi-omics characteristics patients depression/anxiety. In this prospective observational study, 240 Chinese were enrolled, including 129 active (69 Phase 1 60 2; divided into depression/non-depression anxiety/non-anxiety...
Colorectal cancer (CRC) has a high incidence and mortality rate worldwide. Colitis-associated CRC (CAC) is used for describing the relationship between inflammation CRC. No chemopreventive agents have been found to be both effective safe in Therefore, prevention treatment of CAC are extremely urgent. Wu Mei Wan (WMW) clinical enteritis with remarkable efficacy. Here, we aim investigate underlying mechanism WMW CAC. The AOM/DSS-induced mouse model was used, mice were divided into normal...
A new operation scheme on oxide-based resistive-switching devices [resistive random access memory (RRAM)] is proposed to improve the controllability of switching processes in order achieve an improved performance. The device-to-device and cycle-to-cycle uniformity, reduced RESET current, adjustable R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HRS</sub> /R xmlns:xlink="http://www.w3.org/1999/xlink">LRS</sub> ratio are demonstrated HfO...
This study aims to investigate the relationship between daily weather and transmission rate of SARS-CoV-2, develop a generalised model for future prediction COVID-19 spreading certain area with meteorological factors.
Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may regulate excitability of fast-spiking neurons in frontal cortex and participate primary epilepsy pathogenesis. However, exact roles mechanism for NRG1/ErbB4 human symptomatic are still unclear. Using fresh tissues, we found protein levels NRG1 ErbB4 were significantly increased temporal cortex. In addition, NRG1-ErbB4 suppressed phosphorylation GluN2B at position 1472 by Src kinase, decreased level detected...
The six basic emotions (disgust, anger, fear, happiness, sadness, and surprise) have long been considered discrete categories that serve as the primary units of emotion system. Yet recent evidence indicated underlying connections among them. Here we tested relationships using a perceptual learning procedure. This technique has potential causally changing participants' detection ability. We found training on detecting facial expression improved performance not only trained but also other...
Visual cognition in humans has traditionally been studied with cognitive behavioral methods and brain imaging, but much less genetic methods. Perceptual rivalry, an important phenomenon visual cognition, is the spontaneous perceptual alternation that occurs between two distinct interpretations of a physically constant stimulus (e.g., binocular rivalry stimuli) or perceptually ambiguous Necker cube). The switching rate varies dramatically across individuals can be voluntarily modulated by...
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been identified as a DNA sensor. Upon viral infection, hnRNP recognizes pathogen-derived homodimer, which is prerequisite for its translocation to the cytoplasm activate interferon response. However, binding mechanism inducing homodimerization unknown. Here, we show crystal structure of RNA recognition motif (RRM) in complex with U-shaped ssDNA, mediates formation newly observed protein dimer. Our biochemical assays and...
Because the red and bright color of corolla is main indicator for quality assessment good safflower,the dyed safflower sometimes found at herbal market,what influence on this herb efficacy. A total 127 samples was therefore collected from different cultivating areas markets in China to develop a rapid method identify safflower. Near-infrared spectroscopy(NIRS) combined with characteristic identification,high performance liquid chromatography(HPLC),principal component analysis(PCA) partial...
Metabolic networks are complex and highly interconnected, thus systems-level computational approaches required to elucidate understand metabolic genotype-phenotype relationships. This paper has manually reconstructed the local human network based on DNA sequence data of chromosome nine. Herein describes reconstruction process discusses how resulting chromosome-scale (or local) differs from genome-scale ones. The underestimated results have revealed many gaps in current understanding...