A5102881806- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- interferon and immune responses
- T-cell and B-cell Immunology
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Cardiac Imaging and Diagnostics
- Axon Guidance and Neuronal Signaling
- Monoclonal and Polyclonal Antibodies Research
- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Heart Rate Variability and Autonomic Control
- Esophageal Cancer Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Protein Degradation and Inhibitors
City University of Hong Kong
2023-2025
Soochow University
2014-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022-2024
Wenzhou City People's Hospital
2023
Nanjing Drum Tower Hospital
2022-2023
Nanjing University of Chinese Medicine
2023
Zhejiang University
2022
First Affiliated Hospital Zhejiang University
2022
Soochow University
2022
University of Helsinki
2022
The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell activation and also an important therapeutic target for autoimmune diseases. Little known about the regulation functional properties soluble PD-1 (sPD-1) variant. aim this study was to examine role sPD-1 in human murine rheumatoid arthritis (RA).Expression cytokines sera, synovial fluid, peripheral blood (PB) mononuclear cells patients with RA were analyzed by enzyme-linked immunosorbent assay quantitative...
High-frequency stimulation (HFS)-induced long-term potentiation (LTP) is generally regarded as a homosynaptic Hebbian-type LTP, where synaptic changes are thought to occur at the synapses that project from site and terminate onto neurons recording site. In this study, we first investigated HFS-induced LTP on urethane-anesthetized rats found cortical HFS enhances neural responses through strengthening of local connectivity with nearby site, rather than This enhanced leads increased output...
Abstract Background The regulation of protein phosphorylation requires a balance in the activity kinases and phosphatases. Our previous data indicates that Src can increase ERK through Raf kinase response to ischemic stimuli. This study examined molecular mechanisms by which activates cascade phosphatases following cerebral ischemia. Results Ischemia-induced activation is followed PP2A at Tyr307 leading its inhibition rat hippocampus. SU6656, inhibitor, up-regulates activity, resulting...
Abstract In the past decade, mesenchymal stem cells (MSCs) have been widely used for treatment of osteoarthritis (OA), and exosomes may play a major role. Here, we acquired special kind MSCs from bone marrow surgically resected tissue hand patient with polydactyly. Experiments were focused on role polydactyly marrow-derived (pBMSCs) in osteoarthritis. The results showed that pBMSCs had greater ability than BMSCs to differentiate into chondrocytes. Mechanistically, expression BMP4 was...
Objectives The availability of immunotherapies has expanded the options for treating metastatic NSCLC, but information is needed regarding outcomes immunotherapy patients treated outside clinical trials. aim this retrospective study was to evaluate therapy with first-line pembrolizumab plus pemetrexed and carboplatin (pembrolizumab-combination) nonsquamous NSCLC in real-world setting oncology clinics United States (US). Methods Using deidentified, longitudinal patient records from a...
Objective. Programmed cell death 1 (PD-1) induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (RA). Herein, we investigate association PDCD-1 polymorphisms risk RA among Chinese patients healthy controls. Methods. Using PCR-direct sequencing analysis, 4 SNPs (rs36084323, rs11568821, rs2227982, rs2227981) were genotyped 320 309 matched Expression PD-1 was determined...
Glioblastoma multiforme (GBM) is one of the most malignant primary tumors in humans. Despite standard therapeutic strategy with tumor resection combined radiochemotherapy, prognosis remains disappointed. Recently, deubiquitinating enzymes (DUBs) has been reported as potential cancer therapy targets due to their multifunctions involved regulation tumorigenesis, cell cycle, apoptosis, and autophagy. In this study, we found that knockdown ubiquitin specific protease (USP5), a family member DUB,...
Long-term potentiation (LTP), which underlies learning and memory, can be induced by high-frequency electrical stimulation (HFS or HFES) is thought to occur at the synapses of efferent projection. Here, contralateral connectivity in mice auditory cortex was investigated reveal fundamental corticocortical connection properties. After HFES, plasticity not observed terminal recording site. The optogenetic HFS site interhemispheric cortical projections could induce LTP, but HFES LTP. Our...
Esophageal squamous cell carcinoma (ESCC) is a common type of malignant cancer. There growing evidence suggesting that exosomes may participate in the cellular communication tumor-associated fibroblasts (TAFs). However, cisplatin resistance TAF-derived to ESCC cells remains be further studied. Exosomes were isolated from TAFs and characterized with Western blot TEM assays. lines (TE-1 KYSE-150) incubated TAFs-derived exosomes. To explore biological function proliferation, apoptosis,...
Abstract Background Neurogenesis in the adult mammalian hippocampus may contribute to repairing brain after injury. However, Molecular mechanisms that regulate neuronal cell proliferation dentate gyrus (DG) following ischemic stroke insult are poorly understood. This study was designed investigate potential regulatory capacity of non-receptor tyrosine kinase Src on ischemia-stimulated DG and its underlying mechanism. Results activated continuously 24 h 72 transient global ischemia, while...
CD4+CD28− T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal the activation of this subset after CD28 expression downregulated. Tumor necrosis factor receptor superfamily member OX40 a key cells. The aim study was to investigate costimulatory effects on arthritis. Clinical samples were collected from patients with RA and control subjects. Collagen-induced (CIA)...
It has been an established fact that exosomes act as a mediator in tumor microenvironment well participate actively intercellular communication between cancer cells. Exosomes carry variety of molecular cargoes prevent cyclic degradation and represent the cells their origin. In this study, difference expression levels was measured for diagnosis gastric cancer. We isolated from plasma by size-selective method. The morphology characterized transmission electron microscopy, particle size...
Front-line therapy with an EGFR tyrosine kinase inhibitor (TKI) is the standard of care for treating patients advanced nonsquamous NSCLC common sensitizing
The effect of MDANP effects on ER stress signalling not well known or elucidated. Endoplasmic reticulum (ER) plays a critical role in necrotizing enterocolitis (NEC) pathogenesis through the PERK-eIF2ɑ-QRICH1 axis. present study aimed to explore protective NEC development. Firstly, function screening was designed identify candidate peptides human milk, and then identified were validated patients. In vivo, induced mice pups divided into four groups: (1) control group, (2) (3) + (4) NS group....
From in situ growth to invasive dissemination is the most lethal attribute of various tumor types. This transition majorly mediated by dynamic interplay between two cancer hallmarks, EMT and cell cycle. In this study, we applied nonlinear association analysis 33 types found that signaling receptors simultaneously associating with cycle are potential suppressors. Here find a top co-associated receptor, Neogenin (NEO1), inhibits colorectal (CRC) Glioma metastasis forming complex Merlin (NF2),...