A5100641313- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Ubiquitin and proteasome pathways
- Mechanical Circulatory Support Devices
- interferon and immune responses
- Genomics and Rare Diseases
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Inflammasome and immune disorders
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Congenital heart defects research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Genomic variations and chromosomal abnormalities
- Neuroblastoma Research and Treatments
- Neonatal and fetal brain pathology
- RNA regulation and disease
- Neonatal Health and Biochemistry
- Multiple Myeloma Research and Treatments
- Cancer Research and Treatments
- Virus-based gene therapy research
Soochow University
2016-2025
Hebei Medical University
2017-2024
Second Hospital of Hebei Medical University
2017-2024
Children's Hospital of Suzhou University
2016-2024
Shaoxing People's Hospital
2019-2020
Zhejiang University
2019-2020
Soochow University
2020
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, relapse due to drug resistance. Recent studies show that bromodomains extra-terminal (BET) protein inhibitors are promising anti-cancer agents. ARV-825, comprising BET inhibitor conjugated cereblon ligand, was recently developed attenuate the growth multiple tumors in vitro vivo. However, functional molecular mechanisms ARV-825 T-ALL remain...
The present study explored the effect of long non-coding RNA-human ovarian cancer-specific transcript 2 (LncRNA-HOST2) on cell proliferation, migration, invasion and apoptosis human hepatocellular carcinoma (HCC) line SMMC-7721. HCC tissues adjacent normal from 162 patients were collected. lines assigned into control group (regular culture), negative (NC) (transfected with siRNA) experimental Lnc-HOST2 siRNA). Quantitative real-time PCR (qRT-PCR) was used to detect expression LncRNA-HOST2....
We aimed to develop a nomogram predict risk of resistance intravenous immunoglobulin (IVIG) in children with Kawasaki disease eastern China.We retrospectively analysed the data who received IVIG during hospitalisation at Soochow University Affiliated Children's Hospital. was defined as recrudescent or persistent fever ≥36 h after end infusion. Baseline variables were using least absolute shrinkage and selection operator (LASSO) identify predictors resistance, which then used construct...
Neuroblastoma (NB) is one of the most common solid tumors in childhood. To date, targeting MYCN , a well-established driver gene high-risk neuroblastoma, still challenging. In recent years, inhibition bromodomain and extra terminal (BET) proteins shows great potential multiple Myc -driven tumors. ARV-825 novel BET inhibitor using proteolysis-targeting chimera (PROTAC) technology which degrades target by proteasome. this study, we investigated effect neuroblastoma vitro vivo . Our results...
The prediction model of intravenous immunoglobulin (IVIG) resistance in Kawasaki disease can calculate the probability IVIG and provide a basis for clinical decision-making. We aim to assess quality these models developed children with disease.Studies IVIG-resistant were identified through searches PubMed, Web Science, Embase databases. Two investigators independently performed literature screening, data extraction, evaluation, discrepancies settled by statistician. checklist critical...
Kawasaki disease (KD) is the most common pediatric vasculitis. Several models have been established to predict intravenous immunoglobulin (IVIG) resistance. The present study was aimed evaluate efficacy of prediction using medical data KD patients. We collected records patients hospitalized in Department Cardiology Children's Hospital Soochow University with a diagnosis from Jan 2015 Dec 2016. IVIG resistance defined as recrudescent or persistent fever ≥36 h after end their infusion....
Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood with overall 5 years' survival less than 40%.Polo-like kinase 1 (PLK1) a serine/threonine-protein expressed during mitosis and over multiple cancers, including neuroblastoma.We found that higher PLK1 expression related to poor outcome of NB patients.BI2536, small molecule inhibitor against PLK1, significantly reduced cell viability panel lines, IC50 100 nM.PLK1 inhibition by BI 2536 treatment induced cycle arrest at...
The present study used microarray analysis to screen the plasma expression of microRNAs (miRNAs) in patients with acute Kawasaki disease (KD) and aimed explore pathogenesis KD. Plasma was collected from children KD (n=6) healthy control (n=6). Total RNA extracted differential miRNA between two groups determined. Differentially expressed miRNAs were validated using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) an independent cohort (n=8). Target genes differentially...
Kawasaki disease (KD) is an autoimmune with cardiovascular as its main complication, mainly affecting children under 5 years old. KD treatment has made tremendous progress in recent years, but intravenous immunoglobulin (IVIG) resistance remains a major dilemma. Bibliometric analysis had not been used previously to summarize and analyze publications related IVIG KD. This study aimed provide overview of the knowledge framework research hotspots this field through bibliometrics, references for...
POLR3-related leukodystrophy is an autosomal recessive neurodegenerative disorder characterized by onset time ranging from the neonatal period to late childhood, progressive motor decline that manifests as spasticity, ataxia, tremor, and cerebellar symptoms, well mild cognitive regression hypodontia. belongs family of RNA polymerase III-related leukodystrophy, which are caused biallelic mutations in POLR3A, POLR3B, POLRC1, or POLR3K genes. In this study, we report a female child with...
Inhibitor of growth 4 (ING4) is a novel member ING tumor suppressor family and has apparent tumor-suppressive effect. Interleukin-24 (IL-24) as unique cytokine-tumor displays ubiquitous antitumor property tumor-specific killing activity. Multigene-based combination therapy may be an effective practice in cancer gene therapy. The therapeutic potential conjunction ING4 IL-24 for cancers still elusive. This study evaluated the combined effect on SMMC-7721 HepG2 human hepatocarcinoma cells by...
Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the efficacy IFN-I is largely restricted by negative regulators signaling cells. Therefore, identification intracellular inhibitors important developing novel targets to improve therapy. In this study, we report that deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated activity. USP7 physically interacts with suppressor cytokine 1 (SOCS1) and...