A5102785063- Yersinia bacterium, plague, ectoparasites research
- Insect-Plant Interactions and Control
- Bacillus and Francisella bacterial research
- Pharmacological Effects of Natural Compounds
- Insect Pest Control Strategies
- Zoonotic diseases and public health
- Agricultural pest management studies
- Plant and animal studies
- Vibrio bacteria research studies
- Banana Cultivation and Research
- Vector-borne infectious diseases
- RNA Research and Splicing
- Leptospirosis research and findings
- Lichen and fungal ecology
- RNA modifications and cancer
- Amyotrophic Lateral Sclerosis Research
- Dermatology and Skin Diseases
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Algal biology and biofuel production
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Surface Modification and Superhydrophobicity
National Institute for Communicable Disease Control and Prevention
2010-2025
Southwest University of Science and Technology
2024-2025
Guangdong Medical College
2024-2025
Southwest Petroleum University
2023-2024
Jiangxi Normal University
2024
Sun Yat-sen University
2024
Wenzhou Medical University
2024
Environment and Plant Protection Research Institute
2014-2023
Chinese Academy of Tropical Agricultural Sciences
2014-2023
Ministry of Agriculture and Rural Affairs
2019-2023
Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial amyotrophic lateral sclerosis (FALS); however, it is not clear how cause neurodegeneration. Using transgenic mice expressing a common FALS-associated mutation (FUS-R521C mice), we found that mutant proteins formed stable complex with WT and interfered normal interactions between histone deacetylase 1 (HDAC1). Consequently, FUS-R521C exhibited evidence DNA damage as well profound dendritic synaptic...
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), demonstrated to directly bind U1-snRNP and SMN complexes. ALS-causative mutations FUS/TLS are shown abnormally enhance their interaction with dysregulate its function, including loss Gems altered levels small nuclear RNAs. same mutants found have reduced association U1-snRNP. Correspondingly, global RNA analysis reveals a mutant-dependent splicing activity,...
Significance The mechanical integrity of the arterial wall is dependent on a properly structured ECM. Elastin and collagen are key structural components ECM, contributing to stability elasticity normal arteries. Lysyl oxidase (LOX) normally cross-links elastin molecules in process forming proper fibers elastic lamellae. Here, using whole-genome sequencing humans genome engineering mice, we show that missense mutation LOX causes aortic aneurysm dissection because insufficient cross-linking...
Spinetoram, a new type of spinosyn with novel modes action, has been used in effective thrips control programs, but resistance remains threat. In the present study, laboratory Thrips hawaiiensis population was subjected to spinetoram for selection investigate development, stability, cross-resistance potential, biological fitness and underlying biochemical mechanisms.Resistance T. rapidly increased 103.56-fold (for 20 generations spinetoram) compared susceptible population, average realized...
Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role intercellular communication material transfer. In tumor immunity, exosomes present various functions while the following two of great importance: regulating immune response serving as delivery carriers. This review starts with introduction formation, compositions, functions, isolation,...
Microglia play a pivotal role in the coordination of brain development and have emerged as critical determinant progression neurodegenerative diseases; however, microglia onset neurodevelopmental disorders is less clear. Here we show that conditional deletion αVβ8 from central nervous system (Itgb8ΔCNS mice) blocks their normal stepwise immature precursors to mature microglia. These “dysmature” appear result reduced TGFβ signaling during perinatal window, are distinct with induced reduction...
Species displacement by the outcome of interspecific competition is particular importance to pest management. Over past decade, spinetoram has been extensively applied in control two closely related thrips Megalurothrips usitatus and Frankliniella intonsa worldwide, while whether its resistance implicated mediating interplay remains elusive date.Field population dynamics (from 2017 2019) demonstrated a trend toward F. M. on cowpea crops, supporting an existing competition. Following exposure...
We isolated 326 Yersinia enterocolitica strains from 5,919 specimens patients with diarrhea at outpatient clinics, livestock, poultry, wild animals, insect vectors, food, and the environment in cities of Nantong Xuzhou Jiangsu Province, China, 2004 to 2008. The results showed that 12 pathogenic were O:3 serotype. Six domestic dogs (Canis familiaris) belonging farmers found be primary carriers Y. strains, especially Xuzhou. Pulsed-field gel electrophoresis analysis they shared same patterns...
Long noncoding RNAs (lncRNAs) have been verified to participate in various types of malignant tumors, including osteosarcoma (OS), which is the most common primary bone tumor with outstanding morbidity. Although an increasing number lncRNAs reported mediate occurrence OS, potential mechanisms are still unclear. This study intends uncover mechanism by lncRNA LINC01133 functions as miRNA sponge OS tumorigenicity. In this study, we found that expression level was statistically upregulated...
Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in largely unknown. Here, we show that a channel, KCNH6, plays key and glucose hemostasis humans mice. KCNH6 p.P235L heterozygous mutation co-separated with diabetes four-generation pedigree. Kcnh6 knockout (KO) or knockin (KI) mice had phenotype characterized changing hypoglycemia hyperinsulinemia to hyperglycemia deficiency. Islets young KO increased intracellular...
Background Leptospirosis is one of the most important neglected tropical bacterial diseases worldwide. However, there limited information on genetic diversity and host selectivity pathogenic Leptospira in wild small mammal populations. Methodology/Principal findings Jiangxi Province, located southern China, a region highly endemic for leptospirosis. In this study, among total 3,531 trapped rodents dominated by Apodemus agrarius (59.7%), 330 strains were successfully isolated from six...
Formaldehyde is a common gaseous pollutant emitted by buildings and decorative materials. In recent years, growing concerns have been raised regarding its harmful effects on health in indoor air. Therefore, this study aims to investigate the physiological photosynthetic response mechanisms of Racomitrium japonicum under formaldehyde stress. R. was exposed dynamic fumigation with for 7 days, each day comprising an 8-h exposure period within sealed container. The plant structure, pigment...
<title>Abstract</title> Photothermal therapy (PTT) has been an attractive tumor treatment strategy in recent years. Two-dimensional molybdenum disulfide (MoS<sub>2</sub>)-based nanomaterials with high photothermal efficiency is a critical candidate for PTT. However, the tumor-targeting capability extremely needs to be improved effective treatment. In this work, we combine MoS<sub>2</sub> nanodots exosomes, native vesicles secreted from living cells, construct novel exosomes/MoS<sub>2</sub>...
We developed a multilocus sequence typing (MLST) scheme and used it to study the population structure evolutionary relationships of three pathogenic Yersinia species. MLST these species showed complex two clusters, one composed pseudotuberculosis pestis other enterocolitica. Within first cluster, predominant Y. type 90 (ST90) was linked ST43 by locus difference, 81.25% strains were from serotype O:1b, supporting hypothesis that descended O:1b pseudotuberculosis. also found...
Contamination of food and feed by aflatoxin B1 (AFB1) poses serious economic health problems worldwide, so the development biological methods for effective AFB1 degradation is strongly required.Among three AFB1-degrading microorganisms isolated from moldy peanut, Fusarium sp. WCQ3361 could remove extremely effectively, with a ratio 70.20% after 1 min 95.38% 24 h. Its was not much affected temperature change (0-90 °C) it also displayed excellent thermostability, maintaining 99.40% residual...