A5100639170- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Viral Infections and Immunology Research
- Ophthalmology and Visual Impairment Studies
- Dengue and Mosquito Control Research
- Heme Oxygenase-1 and Carbon Monoxide
- Iron Metabolism and Disorders
- RNA and protein synthesis mechanisms
- Intraocular Surgery and Lenses
- Urinary Bladder and Prostate Research
- Microbial bioremediation and biosurfactants
- Hemoglobinopathies and Related Disorders
- Pelvic floor disorders treatments
- Animal Virus Infections Studies
- Chromium effects and bioremediation
- Sexual function and dysfunction studies
- Biosensors and Analytical Detection
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Glaucoma and retinal disorders
- Microbial Applications in Construction Materials
- Zoonotic diseases and public health
- Cytomegalovirus and herpesvirus research
University of Ottawa
2006-2025
Guangzhou Center for Disease Control and Prevention
2021-2024
Third Affiliated Hospital of Southern Medical University
2021
Southern Medical University
2010-2013
Zhujiang Hospital
2010-2013
Guangdong University of Education
2011
Nanjing General Hospital of Nanjing Military Command
2011
Nanjing University
2011
BackgroundIn early 2020, non-pharmaceutical interventions (NPIs) were implemented in China to reduce and contain the coronavirus disease 2019 (COVID-19) transmission. These NPIs might have also reduced incidence of hand, foot, mouth (HFMD).MethodsThe weekly numbers HFMD cases meteorological factors 31 provincial capital cities municipalities mainland obtained from Chinese Center for Disease Control Prevention (CCDC) National Meteorological Information 2016 2020. The NPI data collected local...
Abstract Background Early and accurate diagnosis of dengue infection is essential for control disease outbreaks. Recently, the virus non-structural antigen 1 (NS1), a conserved secreted glycoprotein, has been used as marker early with convenience cost-effectiveness. Serological tests IgM IgG antibodies are still most widely dengue. In order to assess combined diagnostic value these tests, we study kinetic profiles circulating NS1, over course by using an in-house type (DENV1) specific NS1...
ABSTRACT Dengue virus (DENV), a member of the Flavivirus family, has four distinct serotypes (DENV serotype 1 [DENV1], DENV2, DENV3, and DENV4) that require differentiation for effective prevention morbid disease. Early rapid between flaviviruses remains challenging. Full assays combining individual, serotype-specific one group-specific nonstructural protein (NS1) antigen capture enzyme-linked immunosorbent (ELISAs) based on monoclonal antibodies (MAbs) against DENV NS1 were developed...
Two label-free biosensor platforms, Resonance Waveguide Grating (RWG) and Surface Plasmon (SPR), were used to rank a large panel of anti-dengue virus NS1 antibodies. Dengue non-structural 1 (NS1) protein is an established serological marker for the early detection dengue infection. A variety commercial antigen capture immunoassays are available in both ELISA lateral flow format. However, there significant scope improve sensitivity specificity those tests. The interactions antibody...
Dengue virus (DENV) is a mosquito-borne that causes severe health problems. An effective tetravalent dengue vaccine candidate can provide life-long protection simultaneously against all four DENV serotypes highly anticipated. A better understanding of the antibody response to envelope protein domain III (EDIII) may offer insights into development. Here, we identified 25 cross-reactive mAbs from immunization with Pichia pastoris -expressed EDIII single or serotype(s) using prime–boost...
Anemia remains one of the serious nutrition-related diseases in China, but data on incidence anemia were less available, especially rural area which are experiencing rapid urbanization. Out study aimed to estimate both prevalence and transforming China. We conducted a combined adults 18–64 years age with repeated cross-sectional component (4456 2006 2184 2008) cohort (1424) Deqing, was diagnosed based blood hemoglobin levels using hemiglobincyanide (HiCN) method according World Health...
ABSTRACT We compared echovirus 30 strains (FDJS03) which caused an outbreak of aseptic meningitis in China 2003 with other human enterovirus B strains. Sequencing the complete genome FDJS03_84, a representative strain from this outbreak, revealed mosaic structure putative recombination spot within 2B gene. It was most similar to same serotype, E30-14125-00, 5′ half but almost equidistant all analyzed 3′ genome. Phylogenetic relationships 5′-untranslated region and VP1 gene indicated that...
Tick-borne Encephalitis (TBE) is a zoonotic disease caused by the virus (TBEV), which affects central nervous system of both humans and animals. Currently, there no specific therapy for patients with TBE, symptomatic treatment being primary approach. In this study, effects minocycline (MIN), kind tetracycline antibiotic, on TBEV propagation cellular protection in TBEV-infected cell lines were evaluated. Indirect immunofluorescence, titers, RT-qPCR results showed that 48 h post-treatment MIN,...
Yellow fever is an acute infectious disease that common in Africa and South America causes thousands of deaths annually. However, there are very few studies on yellow virus (YFV) antigen detection kits. As a target, the nonstructural protein 1 (NS1) has been successfully used early diagnosis dengue (a member Flaviviridae family) infection. In this study, we monoclonal antibody technology to prepare anti-YFV NS1 antibodies (MAbs) identified their immunological properties. Next, two mouse MAbs...