A5100428296- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Thyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Endometriosis Research and Treatment
- Pituitary Gland Disorders and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Asthma and respiratory diseases
- Regulation of Appetite and Obesity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Polymer-Based Agricultural Enhancements
- Lipid metabolism and disorders
- Acute Lymphoblastic Leukemia research
- Ear Surgery and Otitis Media
- Vitamin K Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sirtuins and Resveratrol in Medicine
- Peptidase Inhibition and Analysis
- Diabetes Management and Education
- Ear and Head Tumors
Jiangyin People's Hospital
2021-2024
Beijing University of Chemical Technology
2024
Harbin Medical University
2009-2023
Shanxi Academy of Medical Sciences
2022
Guangdong Medical College
2022
Ningbo Municipal People's Government
2022
Chinese PLA General Hospital
2021
China Agricultural University
2021
Tianjin Anding Hospital
2021
Tianjin Medical University
2021
Abstract Nanomaterials cannot only act as active ingredients (AIs), but also adjuvants to encapsulate or attach AIs improve their fungicidal activity. Herein, a hydrophilic and lipophilic diblock polymer (HLDP) is designed synthesized prepare series of HLDP nano‐protectants explore the best nano‐protectant for anthracnose management. These results demonstrate that HLDP‐CS displays control effects on mango via direct pathogen inhibition amplified plant immune responses. The can be...
It is unclear why the prevalence of diabetes and prediabetes, especially between diagnosed by oral glucose tolerance test (OGTT) hemoglobin A1c (HbA1c) criteria, substantially discordant.We aimed to evaluate effects obesity on agreement HbA1c OGTT for diagnosing prediabetes identify optimal cutoff values in different body mass index (BMI) classifications.In a population-based, cross-sectional study Harbin, China, 4325 individuals aged 20-74 years without prior were involved this...
Dengue virus (DENV) is a mosquito-borne that causes severe health problems. An effective tetravalent dengue vaccine candidate can provide life-long protection simultaneously against all four DENV serotypes highly anticipated. A better understanding of the antibody response to envelope protein domain III (EDIII) may offer insights into development. Here, we identified 25 cross-reactive mAbs from immunization with Pichia pastoris -expressed EDIII single or serotype(s) using prime–boost...
In this study, we identified 74 differentially expressed autophagy-related genes in glioma patients. Analysis using a Cox proportional hazard regression model showed that MAPK8IP1 and SH3GLB1, two genes, were associated with the prognostic signature for glioma. Glioma patients from CGGA batches 1 2, GSE4412 TCGA datasets could be divided into high- low-risk groups different survival times based on levels of SH3GLB1 expression. The was an independent predictor outcomes overexpression...
The objective of this study was to observe the prognosis pediatric patients with E2A-PBX1-positive acute lymphoblastic leukemia (ALL) from treatment CCLG-ALL2008 protocol.Three hundred and forty-nine Chinese pre-B-cell ALL were enrolled in December 2008 September 2013. Of these, 20 E2A-PBX1 expression 223 without gene stratified into two cohorts. Clinical biological characteristics 5-year event-free survival (EFS), relapse-free (RFS), overall (OS) analyzed compared between these groups.The...
Abstract Somatostatin (SOM) is a 14-amino acid cyclic peptide that regulates granulomatous inflammation. SOM inhibits the release of IFN-γ from murine granuloma T cells express receptors. synthesized as preprosomatostatin (ppSOM), precursor cleaved to active SOM. In this paper, we demonstrate mRNA for important immunoregulator, and inflammatory mediators rapidly induce ppSOM in splenocytes uninfected, normal (NL) mice. We developed sensitive, quantitative PCR assay measures down 100...
Ovarian cancer (OC) is one of the leading causes female deaths. However, molecular pathogenesis OC has still remained elusive. This study aimed to explore potential genes associated with progression OC. In current study, 3 data sets were downloaded from GEO database identify hub gene. Somatic mutation obtained TCGA used analyse mutation. Immune cells estimate effect gene tumour microenvironment. RNA-seq and clinical patients retrieved investigate diagnostic prognostic values A series in...
Abstract Substance P (SP) and somatostatin (SOM) are made at mucosal surfaces sites of inflammation. There is a SP/SOM immunoregulatory circuit that modulates the IFN-γ response in murine schistosomiasis. SP enhances, while SOM decreases, secretion. Various inflammatory mediators induce macrophages to make SOM, but no known factor limits this expression. It was discovered regulates synthesis. Splenocytes from normal, uninfected mice cultured with LPS, IFN-γ, or IL-10 for 4 h strongly...
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are members of the insulin-like factor (IGF) family that play important roles in carcinogenesis. We hypothesized functional polymorphisms IGF-I IGFBP-3 may be associated with risk prostate cancer (PCa) Chinese population. This hospital-based case-control study included 664 PCa patients 702 cancer-free controls. Nine SNPs were genotyped using TaqMan assay. The genetic associations between pathogenesis progression...
The effects of maternal prenatal folic acid supplementation (FAS) on offspring lipid metabolism in adulthood remains unclear, although FAS is compulsively suggested many countries. Female Sprague-Dawley rats were fed with control (CON) or diets before and during pregnancy. Male CON dams further divided into two groups at seven weeks for high-fat (HF) diet interventions eight (n = 10). interactive HF DNA methylation genes involved lipids assessed. male had elevated serum liver triglyceride...
We previously identified Sucrose non-fermenting related kinase (SNRK) as a regulator of adipose inflammation and energy homeostasis. In this study, we aimed to investigate the role SNRK in insulin signaling white (WAT) brown tissue (BAT). Adipose specific (SNRK deficiency both WAT BAT) BAT knockout mouse models were employed. Phosphoproteomic studies conducted identify novel pathway regulating tissue. ablation is sufficient inhibit insulin-stimulated AKT phosphorylation glucose uptake BAT....
Sucrose nonfermenting-related kinase (SNRK) is a member of the AMPK-related family, and its physiological role in adipose energy homeostasis inflammation remains unknown. We previously reported that SNRK ubiquitously abundantly expressed both white tissue (WAT) brown (BAT), but expression diminishes obesity. In this study we report novel experimental findings from animal models human genetics. essential for survival; globally deficient pups die within 24 h after birth. Heterozygous mice are...
Major depressive disorder is a severe neuropsychiatric disease that negatively impacts the quality of life large portion population. However, molecular mechanisms underlying depression are still unclear. The pathogenesis involves several brain regions. most previous studies have focused only on one specific region. Plasma and tissues exchange numerous components through blood‑brain barrier. Therefore, in present study, plasma samples from control (CON) mice subjected to chronic unpredictable...
We report hereditary pituitary hyperplasia. The objective of the study was to describe results clinical and laboratory analysis this rare instance is a retrospective three cases from one family. conducted at National Institutes Health, tertiary referral center. A mother both her sons had very early-onset gigantism associated with high levels serum GH prolactin. condition treated by total hypophysectomy. performed clinical, pathological, molecular evaluations, including evaluation basal...
Traditional Chinese medicine (TCM) plays an important role in the treatment of type 2 diabetes mellitus (T2DM). However, lack adequate and scientifically rigorous evidence has limited its application this disorder. Sanbai melon seed oil (SMSO) is used folk to treat DM; however, only few literature reports exist regarding mechanism. Herein, we aimed confirm antidiabetic activity SMSO a T2DM model further elucidate possible mechanisms. The rat was induced by high-fat sugar diet streptozocin...