A5064299502- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Supramolecular Chemistry and Complexes
- Analytical Chemistry and Sensors
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Diabetes Management and Education
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Lanthanide and Transition Metal Complexes
- Traditional Chinese Medicine Analysis
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Aortic aneurysm repair treatments
- Metal complexes synthesis and properties
- Ion channel regulation and function
- X-ray Diffraction in Crystallography
- Electrochemical sensors and biosensors
China Agricultural University
2025
Dalian University of Technology
2015-2024
Fudan University
2024
Sun Yat-sen University
2024
Dalian University
2011-2024
Yunnan University of Traditional Chinese Medicine
2024
Mudanjiang Medical University
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Beijing Center for Disease Prevention and Control
2024
Quick: An exogenously induced quick increase of the H2S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that target mitochondria. CouMC was constructed combining merocyanine and coumarin fluorophores. The selective nucleophilic addition HS− to derivative at neutral pH is crucial for rapid detection. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may...
An in-depth understanding of the effects drought stress on plant metabolism is necessary to improve tolerance wheat and utilize genetic resources for development stress-tolerant varieties. In this study, profiles 58 key metabolites produced by seedlings in response were investigated determine various physiological processes related between drought-tolerant drought-sensitive genotypes. Results showed that metabolome was dominated sugars, organic acids amino acids; played important roles...
Schnell: Mithilfe einer neuen Sonde, die Mitochondrien markieren kann, lässt sich ein von außen induzierter, schneller Anstieg der H2S-Konzentration (80 s) in MCF-7-Zellen durch ratiometrische Bildgebung visualisieren. Die selektive nukleophile Addition HS− an das Merocyaninderivat bei neutralem pH-Wert ist entscheidend für schnelle H2S-Detektion.
Objective: To explore the correlation between purine-rich food intake and hyperuricemia in Chinese adult residents. Method: A cross-sectional study was conducted on of residents based China Health Nutrition Survey (CHNS) 2009. The subjects were divided into group nonhyperuricemia according to serum uric acid level, differences sociodemographic information (age, gender, region), health status (weight status, blood pressure, sugar status), living habits (alcohol consumption, smoking status)...
Soybean is an important economic crop that continually threatened by abiotic stresses, especially salt stress. Wild soybean germplasm resource for the breeding of cultivated soybean. The root system plays a very role in plant tolerance. To explore tolerance-related mechanisms among Soja, we have demonstrated seedling roots' growth and metabolomics wild soybean, semi-wild under two types stress using gas chromatography-mass spectrometry. We characterized 47 kinds differential metabolites...
Abstract Purpose The aim of this study is to measure the trajectory healthy ageing among Chinese middle-aged and older population, explore disparity trajectory, as well contributing factors, between urban rural areas in China. Methods A total 9402 respondents aged 45 years interviewed four waves (2011, 2013, 2015 2018) were selected from China Health Retirement Longitudinal Study. Healthy score was calculated through item response theory. latent growth mixture model (LGMM) applied...
The pore morphology design of bioceramic scaffolds plays a substantial role in the induction bone regeneration. Specifically, effects different scaffold geometry designs on angiogenesis and new regeneration remain unclear. Therefore, we fabricated Mg/Sr co-doped wollastonite (MS-CSi) with three geometries (gyroid, cylindrical, cubic) compared their osteogenesis vitro vivo. MS-CSi were by digital light processing (DLP) printing technology. structure, mechanical properties, degradation rate...
A novel sensitive and specific Hg(2+) chemodosimeter, derived from 1',3'-dithiane-substituted 2,1,3-benzoxadiazole, displays "turn-on" fluorescent colorimetric responses via an Hg(2+)-triggered aldehyde recovery reaction. Its potential to monitor in living organisms has been demonstrated using zebrafish larvae.
Alzheimer's disease (AD) is a neurodegenerative illness associated with amyloid β-peptide (Aβ) aggregation in the brain. Aβ shows high affinity for metal ions such as Zn2+ and Cu2+, which constitutes major reason related neurotoxicity. Metal chelators are potential therapeutic agents AD because they could sequester from aggregates reverse aggregation. In this study, two macrocyclic platiniferous (PC1, PC2) cyclen metal-chelating unit Pt(bipyridine)Cl2 Aβ-binding have been designed novel...
ICT fluorophore benzoxadiazole with its electron-donating group modified as a Cu2+ chelator was conjugated coumarin to construct new ratiometric sensor reversible intracellular imaging ability.
Abstract The application of metal–organic polyhedra as “molecular flasks” has precipitated a surge interest in the reactivity and property molecules within well‐defined spaces. Inspired by structures natural enzymatic pockets, three neutral molecular tetrahedral, Ce‐TTS, Ce‐TNS Ce‐TBS (H 6 TTS: N′,N′′,N′′′‐nitrilotris‐4,4′,4′′‐(2‐hydroxybenzylidene)‐benzohydrazide; H TNS: N′,N′′,N′′′‐nitrilotris‐6,6′,6′′‐(2‐hydroxybenzylidene)‐2‐naphthohydrazide; TBS: 1,3,5‐ phenyltris...
The development of DNA-targeted photodynamic therapy (PDT) agents for cancer treatment has drawn substantial attention. Herein, the design and synthesis dinuclear IrIII -containing luminescent metallohelices with tunable PDT efficacy that target mitochondrial DNA in cells are reported. fabricated using dynamic imine-coupling chemistry between aldehyde end-capped fac-Ir(ppy)3 handles linear alkanediamine spacers, followed by reduction imine linkages. length odd-even character diamine alkyl...
Fe<sub>3</sub>O<sub>4</sub> nanoparticles with Pt-prodrug payloads display MRI capability and tumor-specific cytotoxicity correlating positively glutathione-mediated DNA cleavage reduction.
Abstract —Smooth muscle cells (SMCs) perform diverse functions that can be categorized as contractile and synthetic. A traditional model holds these distinct are performed by the same cell, virtue of its capacity for bidirectional modulation phenotype. However, this has been challenged, in part because there is no physiological evidence an adult synthetic SMC acquire ability to contract. We sought cloning SMCs from human internal thoracic artery. One clone, HITB5, expressed smooth α-actin,...
Molecules capable of monitoring receptor protein-tyrosine kinase expression could potentially serve as useful tools for cancer diagnosis due to the overexpression tyrosine kinases during tumor growth and metastasis. In this work, a conformationally induced "off-on" cell membrane fluorescent sensor (SP1) was designed evaluated detection imaging in vivo vitro. SP1 consists sunitinib pyrene linked via hexamethylenediamine displays quenched fluorescence dimer. The is restored presence upon...