A5100367949- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
- Plant Physiology and Cultivation Studies
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Algal biology and biofuel production
- Magnesium Alloys: Properties and Applications
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Cell death mechanisms and regulation
- Chromosomal and Genetic Variations
- Atherosclerosis and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- 14-3-3 protein interactions
- Postharvest Quality and Shelf Life Management
- Phytochemistry and Biological Activities
Dalian University of Foreign Languages
2025
Beijing University of Chemical Technology
2023
Yunnan University of Traditional Chinese Medicine
2023
Wuhan University
2023
Hubei Zhongshan Hospital
2023
Air Force Engineering University
2023
Air Force Medical University
2023
Inner Mongolia Medical University
2014-2023
Brunswick (United States)
2023
Henan Academy of Sciences
2021-2022
Obstacle avoidance is the core problem for mobile robots. Its objective to allow robots explore an unknown environment without colliding into other objects. It basis various tasks, e.g. surveillance and rescue, etc. Previous approaches mainly focused on geometric models (such as constructing local cost-maps) which could be regarded low-level intelligence any cognitive process. Recently, deep learning has made great breakthroughs in computer vision, especially recognition tasks. takes...
Chitosan coating is beneficial to maintaining the storage quality and prolonging shelf life of postharvest fruits vegetables, which always used as carrier film for antimicrobial agents. This review focuses on preparation, property, mechanism, application effectiveness vegetables chitosan-based with Chitosan, derived by deacetylation chitin, a modified natural biopolymer material. In this article, safety biocompatible properties chitosan were introduced because these attributes are very...
Vascular smooth muscle cells (SMCs) perform diverse functions and this functional heterogeneity could be based on differential recruitment of distinct SMC subsets. In humans, however, there is little support for such a paradigm, partly because isolation pure human subsets has proven difficult. We report the cloning 12 lines from single fragment internal thoracic artery elucidation 2 cellular profiles. Epithelioid clones (n=9) were polygonal at confluence, 105+/-9 micrometer in length, had...
The Microprocessor complex, consisting of an RNase III DROSHA and the DGCR8 dimer, cleaves primary microRNA transcripts (pri-miRNAs) to initiate (miRNA) maturation. Pri-miRNAs are stem–loop RNAs, ∼79% them contain at least one three major conserved RNA motifs, UG, UGU, CNNC. We recently demonstrated that basal UG apical UGU motifs pri-miRNAs interact with DGCR8, respectively. They help orient on pri-miRNA in a proper direction which localize junctions, In addition, CNNC, located ∼17...
Abstract MicroRNAs (miRNAs) are small RNAs that regulate gene expression. miRNAs produced from primary (pri-miRNAs), which cleaved by Microprocessor. Microprocessor, therefore, plays a crucial role in determining the efficiency and precision of miRNA production, thus function final product. Here, we conducted high-throughput enzymatic assays to investigate catalytic mechanism Microprocessor cleaving randomized pri-miRNAs. We identified multiple mismatches wobble base pairs upper stem...
A macroscopic supramolecular assembly (MSA) refers to non-covalent interactions between building blocks over a micrometer scale, which provides insights into bio-/wet adhesion, self-healing, and so on new fabrication strategies heterogeneous structures bio-scaffolds. The key realize the MSA of rigid materials is pre-modifying compliant coating known as "flexible spacing coating" beneath interactive moieties. However, available coatings are limited polyelectrolyte multilayers with...
Abstract —Smooth muscle cells (SMCs) perform diverse functions that can be categorized as contractile and synthetic. A traditional model holds these distinct are performed by the same cell, virtue of its capacity for bidirectional modulation phenotype. However, this has been challenged, in part because there is no physiological evidence an adult synthetic SMC acquire ability to contract. We sought cloning SMCs from human internal thoracic artery. One clone, HITB5, expressed smooth α-actin,...
Indoor localization is the fundamental capability for indoor service robots and applications on mobile devices. To realize that, cost of sensors great concern. In order to decode signal carried out by LED beacons, we propose two reliable solutions using common available consumer electronic Firstly, introduce a dedicated analog sensor, which can be directly connected microphone input computer or smart phone. It decodes both pattern strength beacon. Secondly, utilize rolling-shutter cameras...
Background/Aims: microRNAs are of vital importance in neural development. As a brain-specific miRNA, miR-132 has been well studied mature neurons. However, its role stem cells (NSCs) remains unclear. In this study, we investigated the regulating NSCs proliferation, differentiation and neuronal maturation. Methods: were obtained from fetal mice spinal cord. Proliferation, cell cycle, apoptosis, motility measured through CCK-8, BrdU, AnnexinV-FITC/PI migration assay respectively. The...
MicroRNAs (miRNAs) play important roles in tumorigenesis and metastasis. In this study, we investigated miR-200b expression endometrial adenocarcinomas normal adjacent tissues found that is more highly expressed cancer than tissues. A novel target of miR-200b, tissue inhibitor metalloproteinase 2 (TIMP2), was predicted using a bioinformatics approach confirmed human cell line HEC-1A cells by luciferase assay, quantitative real-time polymerase chain reaction, western blotting, enzyme-linked...
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist ∼22 nt and involved in several biological processes by regulating target gene expression. MiR-138 has many functions is often downregulated cancers. Our results showed overexpression miR-138 RMND5A (required for meiotic nuclear division 5 homolog A) reduced Exportin-5 stability, which decreased levels pre-miRNA export HeLa cells. We also found could significantly inhibit cell migration targeting RMND5A. study therefore...
Abstract Global educational inequality is influenced by socio-economic development, especially in low-income and conflict-affected regions. Predicting such allows researchers policymakers to design better education policies resource allocation strategies. The Belief Rule Base (BRB) used as an interpretable model that incorporates expert knowledge, making it suitable for these predictions. However, BRBs face challenges, including rule explosion due excessive feature information a lack of...
// Bo Han 1, 2 , Weilong Yao 1 You-Take Oh Jing-Shan Tong 3 Shaohua Li 4 Jiusheng Deng Ping Yue Fadlo R. Khuri Shi-Yong Sun Department of Hematology and Oncology, Emory University School Medicine Winship Cancer Institute, Atlanta, GA, USA State Key Laboratory Oral Disease Head Neck West China Hospital Stomatology, Sichuan University, Chengdu, PR Pharmacology Chemical Biology, Pittsburgh Institute Medicine, Pittsburgh, PA, Beijing Basic Medical Sciences, Beijing, Correspondence to: Sun,...
The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. consists of DROSHA (an RNase III enzyme), and DGCR8. contains two domains, RIIIDa RIIIDb, which simultaneously cleave the 3p- 5p-strands pri-miRNAs, respectively. In this study, we show that internal loop located in lower stem numerous pri-miRNAs selectively inhibits cleavage on their 3p-strand, thereby, facilitating single 5p-strand. This does not lead production but...
MicroRNAs (miRNAs) play critical roles in gene expression and numerous human diseases. The success of miRNA biogenesis is largely determined by the primary (pri-miRNA) processing DROSHA-DGCR8 complex, called Microprocessor. Here, we analysed high-throughput pri-miRNA assays secondary structures pri-miRNAs to investigate bulges processing. We found that multiple places control both cleavage efficiency accuracy These were shown act on Microprocessor via its catalytic subunit, DROSHA, function...
The exploration problem of mobile robots aims to allow explore an unknown environment. We describe indoor algorithm for using a hierarchical structure that fuses several convolutional neural network layers with decision-making process. whole system is trained end by taking only visual information (RGB-D information) as input and generates sequence main moving direction output so the robot achieves autonomous ability. TurtleBot Kinect mounted on it. model tested in real world And training...