A5033051190- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Invertebrate Taxonomy and Ecology
- Prostate Cancer Treatment and Research
- Copper Interconnects and Reliability
- Advanced Proteomics Techniques and Applications
- Muscle Physiology and Disorders
- Lung Cancer Treatments and Mutations
- Electronic Packaging and Soldering Technologies
- Soil Carbon and Nitrogen Dynamics
- Signaling Pathways in Disease
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- RNA and protein synthesis mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2013-2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2023
Wuhan Institute of Bioengineering
2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2014-2017
Beijing Institute of Education
2006-2015
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist ∼22 nt and involved in several biological processes by regulating target gene expression. MiR-138 has many functions is often downregulated cancers. Our results showed overexpression miR-138 RMND5A (required for meiotic nuclear division 5 homolog A) reduced Exportin-5 stability, which decreased levels pre-miRNA export HeLa cells. We also found could significantly inhibit cell migration targeting RMND5A. study therefore...
Abstract Myostatin (MSTN), associated with the “double muscling” phenotype, affects muscle growth and fat deposition in animals, whereas how MSTN adipogenesis remains to be discovered. Here we show that can act through MEF2C/miR222/SCD5 cascade regulate fatty acid metabolism. We generated MSTN-knockout (KO) cloned Meishan pigs, which exhibits typical double muscling trait. then sequenced transcriptome of subcutaneous tissues wild-type (WT) MSTN-KO intersected differentially expressed mRNAs...
// Shaohua Li 1,* , Hui Xiqin Yang Wei Wang 1 Aixue Huang Jie Xingliang Qin Fei 2 Guanyi Lu Hongmei Ding Xueting Su Lvbin Hou Xia Ming Shi Hongwen Zhang 3 Qiang Zhao Dong Xingfeng Ge Leqiao Sun Chenjun Bai Chaonan Xuelian Shen Tao Fang Fusheng 4 Heqiu and Ningsheng Shao Beijing Institute of Basic Medical Sciences, Beijing, China Pharmacology Toxicology, Department Interventional Radiology, General Hospital Fuzhou, Center Infectous Disease, 302 Hospital, * These authors contributed equally to...
As a cleavage enzyme of precursor TNF‐α, the high expression level ADAM17 in endothelial cells is an important factor atherosclerosis. In this study, we demonstrate that target miR‐152. We found miR‐152 could reduce TNF and inhibit cell proliferation migration by targeting human umbilical vein (HUVECs). Furthermore, pattern corresponding was opposite HUVECs under hypoxic conditions. The levels circulating AS patient sera were lower than those detected normal individuals. Our results indicate...
Abstract Background It is well-established that understanding the mechanism of prostate cancer (PCa)-associated metastasis paramount for improving its prognosis. Metastasis known to involve communication between tumor-associated macrophages (TAMs) and tumor cells. Exosomes are crucial in mediating this intercellular within microenvironment. Nonetheless, role exosomal proteins PCa not yet fully understood. Here, we investigated mechanisms cancer-derived PSM-E on regulating macrophage M2...
Abstract GADD45A (growth arrest and DNA damage inducible alpha), a stress response gene induced by genotoxic nongenotoxic stresses, is implicated in various key processes, including the control of cell cycle checkpoints repair. The expression directly regulated numerous transcription factors, with p53 being most representative. Moreover, post-transcriptional regulation also plays role expression. However, little known about regulatory effects microRNAs (miRNAs) on As potential tumour...
Abstract In recent years, p53 was identified to regulate the expression of many miRNAs and also regulated by miRNAs. this paper, we found that miR-138 showed a pronounced increase after activation in human non-small cell lung cancer (NSCLC) cells, which is mediated binding sites promoter region its host gene, but did not happen with rat mouse cells. More interestingly, could be NSCLC Our results suggest existence species-specific differences regulations miRNA against targets itself other proteins.
Abstract Enterovirus A71 (EV‐A71) is a highly contagious virus that poses major threat to global health, representing the primary etiological agent for hand–foot and mouth disease (HFMD) neurological complications. It has been established interferon signaling critical establishing robust antiviral state in host cells, mainly mediated through effects of numerous interferon‐stimulated genes (ISGs). The restriction factor SHFL novel ISG with broad activity against various viruses diverse...
<title>Abstract</title> Background It is well-established that understanding the mechanism of prostate cancer (PCa)-associated metastasis paramount for improving its prognosis. Metastasis known to involve communication between tumor-associated macrophages (TAMs) and tumor cells. Exosomes are crucial in mediating this intercellular within microenvironment. Nonetheless, role exosomal proteins PCa not yet fully understood. Here, we investigated mechanisms cancer-derived PSM-E on regulating...
Different diffusion behavior of Cu, Ni and Zn atoms in Cu/Sn-9Zn/Ni interconnects during liquid-solid electromigration (L-S EM) were investigated under a current density 5.0 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> A/cm xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 230 xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> C. When Cu downwind diffusion, L-S EM enhanced the cross-solder to opposite side compared with...