A5100439405- Antimicrobial agents and applications
- Inhalation and Respiratory Drug Delivery
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Plant Parasitism and Resistance
- Collaboration in agile enterprises
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Advanced Technologies in Various Fields
- Fluorine in Organic Chemistry
- Infectious Encephalopathies and Encephalitis
- Inflammasome and immune disorders
- Neuroscience and Neuropharmacology Research
- Rabies epidemiology and control
- Genetic factors in colorectal cancer
- Phagocytosis and Immune Regulation
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Patient-Provider Communication in Healthcare
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Antimicrobial Peptides and Activities
Sun Yat-sen University
2025
First Affiliated Hospital of Zhengzhou University
2023-2024
Tsinghua University
2013-2024
Huazhong University of Science and Technology
2017-2024
Center for Life Sciences
2024
University of Washington
2023
Shanghai Public Health Clinical Center
2023
Zhengzhou University
2023
China Pharmaceutical University
2023
Wuhan Donghu University
2021
Abstract DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate cGAS-STING (cyclic GMP-AMP synthase—stimulator interferon genes) pathway in antigen-presenting (APCs) and promote antitumor immunity. However, conventional chemotherapy displays limited cell killing ineffective transfer stable to APCs. Here we show liposomes loaded with an optimized ratio indocyanine green doxorubicin, denoted as LID, efficiently...
Reactive oxygen species (ROS) play an important role in regulating the immune system by affecting pathogens, cancer cells, and cells. Recent advances biomaterials have leveraged this mechanism to precisely modulate ROS levels target tissues for improving effectiveness of immunotherapies infectious diseases, cancer, autoimmune diseases. Moreover, ROS-responsive can trigger release immunotherapeutics provide tunable kinetics, which further boost their efficacy. This review will discuss latest...
Arabidopsis NONHOST1 ( NHO1 ) is required for limiting the in planta growth of nonhost Pseudomonas bacteria but completely ineffective against virulent bacterium syringae pv. tomato DC3000. However, molecular basis underlying this observation remains unknown. Here we show that transcriptionally activated by flagellin. The P. tabaci lacking flagellin unable to induce , multiplies much better than does wild-type bacterium, and causes disease symptoms on . DC3000 also possesses potent...
Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, current H129 derived tracers are multisynaptic, neither bright enough to label details of neurons nor capable determining direct projection targets as monosynaptic tracer.Based on bacterial artificial chromosome H129, we have generated serial recombinant viruses for tracing. Among them, H129-G4 was obtained by...
Abstract Choline acetyltransferase neurons in the vertical diagonal band of Broca (vChATs) degenerate early stage Alzheimer’s disease (AD). Here, we report that vChATs directly innervate newly generated immature (NGIs) dorsal hippocampus (dNGIs) adult mice and regulate both dNGIs survival spatial pattern separation. In a mouse model exhibits amyloid-β plaques similar to AD patients, cholinergic synaptic transmission, dNGI separation are impaired. Activation with theta burst stimulation (TBS)...
The solid electrolyte interphase (SEI) offers effective passivation on the anode for aqueous lithium-ion batteries (ALIBs). Conventional in ALIBs mainly relies LiF-contained SEI originating from anion reduction electrolyte. However, such formation is a competitive reaction negatively impacted by parasitic hydrogen evolution (HER), resulting high Li+ irreversible consumption and imperfect bare flaws. To address this issue, we propose preconstructing an artificial introducing multifunctional...
Pathogens induce pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered (ETI) in plants. PAMPs are microbial molecules recognized by host plants as nonself signals, whereas pathogen effectors evolved to aid parasitism but sometimes specific intracellular resistance proteins. In the absence of detectable ETI determining classical incompatible interactions, basal exists during compatible nonhost interactions. What triggers has remained elusive. Here, we...
This study aimed to assess the level of public trust in general practitioners (GPs) and its association with primary care contract services (PCCS) China. Cross-sectional study. Between September December 2021, 4158 residents across eastern, central, western China completed a structured self-administered questionnaire. Trust was assessed using Chinese version Wake Forest Physician Scale. Multivariable linear regression models were established identify predictors trust. The effect size PCCS on...
Activating the STING pathway in cytosol of tumor-infiltrating antigen-presenting cells (APCs) represents a promising strategy to elicit potent antitumor immune responses for cancer therapy. However, agonists are mostly small hydrophilic molecules that suffer from rapid clearance and poor cytosolic delivery following systemic administration. While various nanoparticles have been developed promote delivery, they often exhibit premature drug release during circulation. Alternatively, stable...
Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading cytosolic nucleic acids, we...
Turnover among general practitioners (GPs) has become a significant public health concern worldwide.This study aimed to investigate the interrelationships between job satisfaction, professional identity, burnout, and turnover intention GPs in China assess mediating effect of satisfaction on association burnout moderating identity satisfaction.A cross-sectional was conducted collect data from 3,236 eastern, central, western October 2017 February 2018 using self-administered questionnaire....
Leukemia remains incurable partly due to difficulties in reaching and maintaining therapeutic drug concentrations the target tissues cells. Next-generation drugs targeted multiple cell checkpoints, including orally active venetoclax (Bcl-2 target) zanubrutinib (BTK target), are effective have improved safety tolerability compared conventional, nontargeted chemotherapies. However, dosing with a single agent frequently leads resistance; asynchronous coverage peak-and-trough time-course of two...
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<div>Abstract<p>Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading...
<div>Abstract<p>Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, suffers from rapid degradation poor endosomal escape, thus limiting its potency. Inspired the structure virus that utilizes internal viral proteins tune loading...
Poly I:C (pIC) can act on endosomal and cytosolic pathogen recognition receptors to enhance T cell immunity. However, the poor delivery of pIC lack facile methods for codelivery with antigens limit its efficacy. Inspired by structure a virus, we developed
According to the Shanghai Municipal Health Commission, as of May 4, 2022, there were 601,942 COVID-19 patients in Shanghai, among which 547,056 asymptomatic.1 The viral genomes responsible for recent infections belonged SARS-CoV-2 BA.2 subtype; Omicron strain has lower rate critical illness and mortality than previous Delta strains.2, 3 Despite its low toxicity mild symptomatology most patients, this condition largely affects society, economy, work, life. main criterion determining patients'...