A5015678905- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Balance, Gait, and Falls Prevention
- Neurogenesis and neuroplasticity mechanisms
- Restless Legs Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Sleep and related disorders
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Cerebral Palsy and Movement Disorders
- Genetics and Neurodevelopmental Disorders
- Immune Response and Inflammation
- Ginkgo biloba and Cashew Applications
- Mitochondrial Function and Pathology
- Precipitation Measurement and Analysis
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Dysphagia Assessment and Management
- Engineering Applied Research
- Spatial Neglect and Hemispheric Dysfunction
Nanjing Brain Hospital
2013-2022
Nanjing Medical University
2012-2022
Beijing Anzhen Hospital
2017
Fundación Juan March
2007
In-Q-Tel
2007
Nanjing University
2007
Second Affiliated Hospital of Chongqing Medical University
2003
Dalian Medical University
2003
Chongqing Medical University
2003
Université Laval
1995
1. To characterize the physiological properties of lateral and basolateral (BL) amygdaloid neurons, intracellular recordings were performed in barbiturate-anesthetized cats. Morphological identification recorded cells was achieved by injection neurobiotin. Two types physiologically identified projection neurons distinguished BL nuclei. 2. The first type prevailed nucleus (80% cells). Their resting membrane potential (Vm) averaged -66 +/- 4.9 (SE) mV. They generated stereotyped spike doublets...
Epilepsy is one of the most common chronic neurological disorders which provoke progressive neuronal degeneration. Endoplasmic reticulum (ER) stress has recently been recognized as pivotal etiological factors contributing to epilepsy-induced damage. However, specific contribution epilepsy made ER remains largely elusive. Here we use pentylenetetrazole (PTZ) kindling, a model, identify nitric oxide synthase (nNOS) signaling molecule triggering PTZ kindling and oxidative By genetic deletion...
Abstract Objective Impairment of basal ganglia (BG)‐thalamo‐cortical circuit causes various symptoms Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns putamen among PD subtypes and healthy control (HC) explored their clinical significance. Methods A total 16 patients with tremor‐dominant (TD) PD, 23 postural instability gait difficulty‐dominant (PIGD) 31 HC that underwent magnetic resonance imaging were observed. Voxel‐wise FC analysis was performed by...
Epilepsy is a chronic neurological disease which usually associated with psychiatric comorbidities. Depression and cognition impairment are considered to be the most common comorbidities in epilepsy patients. However, specific contribution of made these remains largely unknown. Here we use pentylenetetrazole (PTZ) kindling, model, identify neuronal nitric oxide synthase (nNOS) as signaling molecule triggering PTZ kindling-induced cognitive depressive-like behavior. Furthermore, identified...
Hydrogen sulfide (H 2 S), a novel endogenous gasotransmitter, has been considered neuromodulator to enhance hippocampal long‐term potentiation and exerts neuroprotective effects against neurotoxin‐induced neurodegeneration in rodent models of Parkinson's disease (PD). However, whether H S can function as regulate the levels nigrostriatal neurotransmitters then impact vulnerability dopaminergic (DA) neurons response neurotoxins remains unknown. For this study, we prepared...
Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 patients who were admitted hospital. Patients categorized as normal nutrition or at risk malnutrition/already malnourished. Questionnaires, physical examinations, biochemical tests conducted. PD analyzed using t -tests, χ 2 logistic regression models. Results: prevalence malnutrition [defined a Mini Nutritional Assessment (MNA)...
Resveratrol (trans-3,4',5-trihydroxystilbene, RES) is a naturally occurring lipophilic antioxidant that has been intensively studied for its promising efficacy in treating oxidative stress-associated disorders. Despite the array of bioactivities it possesses, RES low bioavailability due to poor aqueous solubility and dissolution properties. Recent nanotechnology led effective development drug delivery systems. In this study, RES-loaded nanoparticles (RES-NPs) were prepared based on...
Previous studies found levodopa could improve the activity of ankle joints patients with Parkinson's disease (PD). But joint movement is composed four motion ranges. The specific changes ranges in PD remain unknown. purpose this study was to decompose complex movement, measure before and after acute challenge test (ALCT), investigate effects these parameters on gait performance. 29 30 healthy control subjects (HC) completed Instrumented Stand Walk (ISAW) were collected by JiBuEn analysis...
Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease (AD). Environmental enrichment (EE) has shown significant beneficial effects on functional improvement in AD. In this study, we sought determine whether combining these two distinct therapies would yield greater benefit than either drug used alone. We investigated effect memantine combined with EE spatial learning and memory AD-like pathology widely AD model,...
Background and Purpose: The unilateral onset persistent asymmetry of motor symptoms are important characteristics Parkinson's disease (PD). By using scales wearable sensors, this study explored whether symptom laterality could affect non-motor gait performance. Methods: A total 130 right-handed patients with PD were enrolled in our divided into two groups according to the side predominant presentation by Unified Disease Rating Scale part III. We measured Non-motor Scale, sleep quality Sleep...
Neuroinflammation has been recognized as a factor in the pathogenesis of neurodegenerative diseases. Emerging evidence suggests that peripheral inflammation, besides neuroinflammation, functions modulator disease progression and neuropathology several However, detailed correlations among neuroinflammation neurodegeneration remain unknown. In present study, we prepared inflammation model with lipopolysaccharides (LPS)-stimulated RAW264.7 macrophages to explore its activation on BV2 microglia....
Purpose: Parkinson's disease (PD) patients frequently present with sleep disorders. This study was designed to assess the impact of nonmotor symptoms (NMSs) on quality in early-stage PD and without cognitive dysfunction. Materials Methods: A sample 389 (modified Hoehn Yahr score ≤ 2.5, duration 5 years) recruited for study. The Non-Motor Symptoms Questionnaire (NMS-Quest) used screen global NMSs. Depressive were assessed using Hamilton Rating Scale Depression (HAMD). motor measured Unified...
32 patients with early-stage PD and 30 healthy control subjects (HC) were enrolled. All participants completed the instrumented stand walk test, gait data was collected using wearable sensors. We observed increased variability of stride length (SL) (P < 0.001), stance phase time (StPT) = 0.004), swing (SwPT) 0.011) in PD. There decreased heel strike (HS) range motion knee 0.036), hip joints 0.001) In symmetry analysis, no difference found any assessed parameters between HC Only total steps...
Gait impairment is a common clinical symptom of patients with Parkinson's disease (PD). Detecting specific gait parameters' changes in order to guide intervention at present lacking. The study aimed (1) quantify impairments different PD subtypes and (2) explore whether the results quantitative analysis are beneficial treatment.We enrolled 86 (48 men, 38 women) from Department Geriatrics Affiliated Brain Hospital Nanjing Medical University. Unified Disease Rating Scale (UPDRS) Hoehn-Yahr were...
Little is known about the nutritional status and clinical characteristics of patients with Parkinson's disease freezing gait (PDFOG). The purpose this study was to describe relationship between PDFOG.In cross-sectional study, 178 PDFOG were recruited classified as nutritionally normal or at risk malnutrition/already malnourished based on their Mini Nutritional Assessment (MNA) scores. Each participant underwent a structured questionnaire, physical examination routine serum biochemical...