A5100425151- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Total Knee Arthroplasty Outcomes
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Adrenal and Paraganglionic Tumors
- MRI in cancer diagnosis
- Renal and related cancers
- Orthopaedic implants and arthroplasty
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Pleural and Pulmonary Diseases
- Advanced MRI Techniques and Applications
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Gastric Cancer Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
Peking University
2011-2025
Beijing Jishuitan Hospital
2011-2025
Affiliated Hospital of Qingdao University
2018-2024
Qingdao University
2013-2024
Central South University
2019-2024
Research Center Borstel - Leibniz Lung Center
2024
Xiangya Hospital Central South University
2019-2024
University of Science and Technology of China
2024
University Hospital Regensburg
2024
Uppsala University
2023-2024
Objectives Circular RNAs (circRNAs) have been proven to function as competing endogenous interact with microRNAs (miRNAs) and influence the expression of miRNA target mRNAs. In this study, we investigated whether circRNAs could act regulate pathological process intervertebral disc degeneration (IVDD). Methods The role mechanism a circRNA, circVMA21, in IVDD were explored nucleus pulposus (NP) cells degenerative NP tissues from patients rat models. interaction between circVMA21 miR-200c well...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by distinct genotype-phenotype relationships according to studies largely restricted Caucasian populations. Objective To assess for possible differences in genetic landscapes of PPGLs Chinese versus European Design Cross-sectional study. Setting 2 tertiary-care centers China 9 Europe. Participants Patients with pathologically confirmed diagnosis PPGL, including 719 919 Europeans. Main Outcome Measures...
Accurate and noninvasive detection of isocitrate dehydrogenase (IDH, including IDH1 IDH2) status is clinically meaningful for molecular stratification glioma, but remains challenging.To establish a model classifying IDH in gliomas based on multiparametric MRI.Retrospective, radiomics.In all, 105 consecutive cases grade II-IV glioma with 50 or IDH2 mutant (IDHm) 55 wildtype (IDHw) were separated into training cohort (n = 73) test 32).Contrast-enhanced T1 -weighted (CE-T1 W), T2 (T2 arterial...
Tumour evolution with acquisition of more aggressive disease characteristics is a hallmark disseminated cancer. Metastatic pancreatic neuroendocrine tumours (PanNETs) in particular may progress from low/intermediate to high-grade disease. The aim this work was understand the molecular mechanisms underlying metastatic progression as well PanNET transformation We performed multi-omics analysis (genome/exome sequencing, total RNA-sequencing and methylation array) 32 longitudinal samples six...
Purpose Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes the tumor, or results solely from stable genetic resistant tumor cells. Experimental Design Mice bearing two human RCC xenografts were treated with sorafenib until they acquired resistance. Resistant 786-O cells harvested and reimplanted into naïve mice. A498 subjected a 1 week treatment break. Sorafenib was then again...
This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.Patients ≥ grade 2 received 20 acupuncture treatments over 9 weeks.For the 19 evaluable patients, Functional Assessment Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002)....
Abstract Major depressive disorder (MDD) is a prevailing chronic mental with lifetime recurring episodes. Recurrent depression (RD) has been reported to be associated greater severity of depression, higher relapse rate and prominent functioning impairments than first-episode (FED), suggesting the progressive nature depression. However, there still little evidence regarding brain functional connectome. In this study, 95 medication-free MDD patients (35 FED 60 RD) 111 matched healthy controls...
Treatment of metastatic renal cell cancer (RCC) with antiangiogenic agents that block vascular endothelial growth factor (VEGF) receptor 2 signaling produces tumor regression in a substantial fraction patients; however, resistance typically develops within 6 to 12 months. The purpose this study was identify molecular pathways involved resistance. mice bearing either 786-0 or A498 human RCC xenografts sorafenib sunitinib produced stabilization followed by regrowth despite continued drug...
Abstract BACKGROUND: Microwave ablation has recently been developed as a safe and effective treatment for variety of tumors. The authors evaluated the safety efficacy computed tomography (CT)‐guided percutaneous microwave adrenal malignant METHODS: Nine patients between 41 83 years age (average age, 54 years) with carcinoma (a total 10 lesions) received CT‐guided water‐cooled ablation. 9 cases included 1 primary adrenocortical 8 metastatic carcinomas (4 from lung cancer, 2 hepatocellular...
Angiopoietin 2 (Ang2) is a secreted glycoprotein upregulated at sites of angiogenesis and has been implicated in cancer neovascularization. Recent studies have suggested efficacy combined Ang vascular endothelial growth factor receptor (VEGFR) inhibition for patients with metastatic renal cell carcinoma (mRCC). We measured Ang2 expression human tissue plasma, tested the effect dual Ang1/2 (trebananib; AMG386) or alone (L1-7) VEGFR on murine RCC blood flow. levels were higher tumors than...
Intractable bleeding caused by radiation-induced gastritis is rare.We describe a 69-year-old man with intractable hemorrhagic induced postoperative radiotherapy for the treatment of esophageal carcinoma.Although anti-secretory therapy or without octreotide was initiated hemostasis over three months, melena still occurred off and on, patient required blood transfusions to maintain stable hemoglobin.Finally growth hormone used in hemorrhage two weeks, successfully achieved.This first report...
Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be major deficit independently caused by depression at acute episodes MDD. Methods: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention and memory in 162 MDD patients 142 healthy controls (HCs). multivariate analysis variance, hierarchical regression analyses general linear were explore...
Abstract Background Rhabdomyosarcoma (RMS), a common soft-tissue malignancy in pediatrics, presents high invasiveness and mortality. However, besides known changes the PAX3/7-FOXO1 fusion gene alveolar RMS, molecular mechanisms of disease remain incompletely understood. The purpose study is to recognize potential biomarkers related with RMS analyse their mechanism, diagnosis prognostic significance. Methods Gene Expression Omnibus was used search normal striated muscle data sets....
To establish and validate an intact rotator cuff rat model for exploring the pathophysiological effects of type 2 diabetes on tendon in vivo.A total 45 adult male rats were randomly divided into a control group (n = 9) (n=36). The sacrificed at weeks (T2DM-2w group, n=9), 4 (T2DM-4w 8 (T2DM-8w 12 (T2DM-12w n=9) after successful modeling diabetes. Bilateral shoulder samples collected gross observation measurement, protein expression(enzyme-linked immunosorbent assay,ELISA), histological...