A5032636991- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Functional Brain Connectivity Studies
- High Altitude and Hypoxia
- Sleep and Wakefulness Research
- Treatment of Major Depression
- RNA modifications and cancer
- Tracheal and airway disorders
- AI in cancer detection
- Sleep and related disorders
- Thyroid Cancer Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Neurotransmitter Receptor Influence on Behavior
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Menstrual Health and Disorders
Affiliated Zhongshan Hospital of Dalian University
2024
Yuhuangding Hospital
2023-2024
Sichuan University
2024
Cell Technology (China)
2023
Qingdao University
2023
Nanjing University
2020-2023
Donghua University
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
University of Washington
2023
Shenzhen KangNing Hospital
2022
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high risk metastasis, but the exact molecular mechanisms metastasis are not yet understood.This study acquired single-cell transcriptomics profiling 11 distal normal tissues, primary LUAD and 4 metastatic tissues from GSE131907 dataset. The multicellular ecosystems were characterized at resolution, potential underlying angiogenesis explored.We constructed global landscape 93,610 cells found that IGF2BP2 was specifically...
Successful automated diagnoses of attention deficit hyperactive disorder (ADHD) using imaging and functional biomarkers would have fundamental consequences on the public health impact disease. In this work, we show results predictability ADHD discuss scientific diagnostic impacts research. We created a prediction model landmark 200 data set focusing resting state connectivity (rs-fc) structural brain imaging. predicted status subtype, obtained by behavioral examination, data, intelligence...
Summary We consider the problem of jointly estimating multiple graphical models in high dimensions. assume that data are collected from n subjects, each which consists T possibly dependent observations. The subjects vary, but assumed to change smoothly corresponding a measure closeness between subjects. propose kernel-based method for all models. Theoretically, under double asymptotic framework, where both (T, n) and dimension d can increase, we provide an explicit rate convergence parameter...
Thomas Hartung1,2*Lena Smirnova1Itzy E. Morales Pantoja1Akwasi Akwaboah3Dowlette-Mary Alam El Din1Cynthia A. Berlinicke4J. Lomax Boyd5Brian S. Caffo6Ben Cappiello7Tzahi Cohen-Karni8,9J. Lowry Curley7Ralph Etienne-Cummings3Raha Dastgheyb10David H. Gracias11,12,13,14,15,16Frederic Gilbert17Christa Whelan Habela10Fang Han18Timothy D. Harris19,20Kathrin Herrmann1Eric J. Hill21Qi Huang11Rabih Jabbour22Erik C. Johnson20Brett Kagan23Caroline Krall1Andre Levchenko24Paul Locke1Alexandra...
Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be major deficit independently caused by depression at acute episodes MDD. Methods: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention and memory in 162 MDD patients 142 healthy controls (HCs). multivariate analysis variance, hierarchical regression analyses general linear were explore...
Purpose: High myopia (HM) is defined as a refractive error worse than −6.00 diopter (D). This study aims to update the phenotypic and genotypic landscape of nonsyndromic HM establish biological link between traits genetic deficiencies. Methods: A cross-sectional involving 731 participants varying in error, axial length (AL), age, myopic retinopathy, visual impairment. The were analyzed by four ophthalmologists while mutational screening was performed eight autosomal causative genes. Finally,...
Both environmental and genetic factors contribute to the etiology of autoimmune thyroid disease (AITD) including Graves' (GD) Hashimoto's thyroiditis (HT). However, exact pathogenesis interactions that occur between genes remain unclear, therapeutic targets require further investigation due limited options. To solve such problems, this study utilized single-cell transcriptome, whole full-length transcriptome (Oxford nanopore technology), metabolome sequencing examine lesion tissues from 2 HT...
The thalamus is a key region for the transmission of nociceptive information in central modulation pain and has been studied setting numerous chronic conditions. Brain-derived neurotrophic factor (BDNF) considered an important modulator mediating pathways pain. present study aimed to investigate whether there was thalamus-related abnormal functional connectivity or relevant serum BDNF level alterations during periovulation long-term primary dysmenorrhea (PDM). Thalamic subregions were...
Non-suicidal self-injury (NSSI) is a serious public health problem widely present among young adults and adolescents. While finding risk factors associated with NSSI patients major depressive disorder (MDD) challenging, the current study aims to measure childhood adversity serum cortisol levels elucidate their relationship in MDD NSSI.In this cross-sectional study, 126 (aged 16 35 years) were recruited. The symptoms assessed by Beck Depression Inventory (BDI-II), was evaluated Chinese...
Abstract Double‐stranded RNA (dsRNA) is a major impurity that can induce innate immune responses and cause adverse drug reactions. Removing dsRNA an essential non‐trivial process in manufacturing mRNA. Current methods for elimination use either high‐performance liquid chromatography or microcrystalline cellulose, rendering the complex, expensive, toxic, and/or time‐consuming. This study introduces highly efficient ultrafast method using natural wood‐derived macroporous cellulose (WMC). With...
Objective The aim of the study was to explore tendency modified electroconvulsive therapy (MECT)-related working memory and subjective deficits in depressed patients. Methods Sixty patients with unipolar/bipolar depression were prepared enrolled for MECT 56 subjects as healthy controls (HCs). Their demographics (sex, age, body mass index, years schooling, etc) clinical characteristics (dosage number MECT, compared. Depression severity, memory, measured using Hamilton Rating Scale 17 (HAMD ),...