A5051156124- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Advanced X-ray and CT Imaging
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Long-Term Effects of COVID-19
- Vascular Tumors and Angiosarcomas
- Dermatology and Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Neonatal Respiratory Health Research
- MRI in cancer diagnosis
- Voice and Speech Disorders
- Autophagy in Disease and Therapy
- Polyamine Metabolism and Applications
Yuhuangding Hospital
2020-2025
Qingdao University
2020-2025
Weatherford College
2024
Cell Technology (China)
2023
State Key Laboratory of Oncology in South China
2022
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high risk metastasis, but the exact molecular mechanisms metastasis are not yet understood.This study acquired single-cell transcriptomics profiling 11 distal normal tissues, primary LUAD and 4 metastatic tissues from GSE131907 dataset. The multicellular ecosystems were characterized at resolution, potential underlying angiogenesis explored.We constructed global landscape 93,610 cells found that IGF2BP2 was specifically...
Objectives This study aimed to develop a computed tomography (CT)-based radiomics model predict central lymph node metastases (CLNM) preoperatively in patients with papillary thyroid carcinoma (PTC). Methods In this retrospective study, 678 PTC were enrolled from Yantai Yuhuangding Hot3spital (n=605) and the Affiliated Hospital of Binzhou Medical University (n=73) within August 2010 December 2020. The randomly divided into training set (n=423), an internal test (n=182), external (n=73)....
Macrophages played an important role in the progression and treatment of head neck squamous cell carcinoma (HNSCC). We employed weighted gene co-expression network analysis (WGCNA) to identify macrophage-related genes (MRGs) classify patients with HNSCC into two distinct subtypes. A risk signature (MRS) model, comprising nine genes: IGF2BP2, PPP1R14C, SLC7A5, KRT9, RAC2, NTN4, CTLA4, APOC1, CYP27A1, was formulated by integrating 101 machine learning algorithm combinations. observed lower...
ABSTRACT Background Hashimoto's thyroiditis (HT) is the most common organ‐specific autoimmune disease, and its etiology may be related to genetic, environmental, epigenetic factors. However, exact pathogenesis remains elusive. Methods In this study, single‐cell transcriptomic sequencing bioinformatics analysis were performed on thyroid tissues of six HT patients, peripheral blood mononuclear cells (PBMCs) four normal tissue one healthy control. A panoramic atlas was constructed explore...
Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring need for early diagnosis to improve patient outcomes. Tumor-derived exosomes, which can be non-invasively obtained reflect metabolic state of tumors in real-time, are under increasing investigation their diagnostic potential. Herein we analyzed metabolite differences serum, tissues from patients with HNSCC identify potential biomarkers clinical relevance. Non-targeted metabolomics based on...
Introduction: Tumor‐infiltrating B cells (TILBs) are an important part of the immune response during tumor regulation. However, significance in immunotherapy has not been fully determined. Methods: In this study, highly expressed genes were obtained by comparing gene expression with that other and named TILB‐mRNAs. Among them, those patients head neck squamous cell carcinoma (HNSCC) identified The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) atlas employed to screen for...
Several studies have indicated an association between major depressive disorder (MDD) and allergic diseases (ADs), but the exact causal relationship remains inconclusive. Thus, this study aimed to explore MDD ADs employing bidirectional two-sample Mendelian randomization (MR). The summary statistics for were sourced from Psychiatric Genomics Consortium. Single nucleotide polymorphisms (SNPs) associated with asthma (AAS), rhinitis (AR), atopic dermatitis, extracted FinnGen inverse variance...
Objectives To develop and validate a Computed Tomography (CT) based radiomics nomogram for preoperative predicting of extrathyroidal extension (ETE) in papillary thyroid cancer (PTC) patients Methods A total 153 were randomly assigned to training internal test sets (7:3). 46 recruited serve as an external set. radiologist with 8 years experience segmented the images. Radiomics features extracted from each image Delta-radiomics calculated. Features selected by using one way analysis variance...
Immune-inflammatory response is a key element in the occurrence and development of olfactory dysfunction (OD) patients with allergic rhinitis (AR). As one core factors immune-inflammatory responses, interleukin (IL)-6 closely related to pathogenesis diseases. It may also play an important role OD induced by diseases, such as Sjögren's syndrome coronavirus disease 2019. However, there no study has reported its AR. Thus, this aimed investigate IL-6 AR-related OD, attempt discover new target...
MicroRNA (miR)-146a, as an important immune regulatory factor with anti-inflammatory effect, plays a crucial role in T-cell (Tregs) differentiation and function allergic rhinitis (AR). The present study aimed to investigate the mechanism employed by miR-146a control Treg AR.Expression of STAT5b peripheral blood mononuclear cells (PBMCs) nasal mucosa from patients AR was detected qPCR Western blotting. Tregs were quantified flow cytometry knockdown or PBMCs. FOXP3, IL-10, TGF-β levels...
Abstract Background Cervical lymphangioma usually occurs in children and is relatively rare adults. The purpose of this study was to investigate the characteristics cervical lymphangiomas Methods We retrospectively reviewed medical records analyzed clinical data obtained from seven adult patients who suffered January 2008 June 2021. Results Five (71.43%) cases were asymptomatic four (57.14%) had a maximum diameter ≥ 10 cm. Each located adjacent carotid sheath. All completely surgically...
Abstract The pathogenesis of allergic rhinitis (AR)‐related olfactory dysfunction (OD) remains unknown. Inhibiting microglial response in bulb (OB) can ameliorate AR‐related OD, but no precise targets have been available. In this study, we established a mouse model ovalbumin (OVA)‐induced AR and combined with the application P2X7 receptor (P2X7R)‐specific antagonists cell culture conditioned medium to investigate role mechanism OB P2X7R OD. Serum IgE IL‐5 levels determined via ELISA...
Neutrophil infiltration plays a key role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, pertinent mechanisms remain poorly elucidated. Here, we obtained data from gene expression omnibus (GEO) and set enrichment analysis (GSEA) to identify validate neutrophil-associated hub genes CRSwNP. We found that four genes, namely ICAM1, IL-1β, TYROBP, BCL2A1, were markedly upregulated positively correlated neutrophil levels patients Subsequently, this was confirmed...
To develop and validate a radiomics nomogram for identifying sub-1 cm benign malignant thyroid lesions.
The aim of this study was to explore the role and mechanism olfactory bulb (OB) microglial P2X7 receptor (P2X7R) in allergic rhinitis (AR)-related depression, with objective identifying a potential clinical target. An AR mouse model induced using ovalbumin (OVA), while chronic stress employed induce depression. used P2X7R-specific antagonists OB microglia-specific P2X7R knockdown mice as crucial tools. results showed that OVA + group exhibited more pronounced depressive-like phenotypes....
Establish an in situ model for investigating HNSCC, focusing on tumor growth, metastasis, and the immune microenvironment.
Objective We aim to establish and validate computed tomography (CT)-based radiomics model for predicting TP53 status in patients with laryngeal squamous cell carcinoma (LSCC). Methods divided all into a training set 1 (n=66) testing (n=30) predict TP53. Radiomics features were selected by analysis of variance (ANOVA) the least absolute shrinkage selection operator (Lasso) regression analysis. Five models established using K-Nearest Neighbor, logistics regressive, linear-support vector...