A5101972950- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Nanoparticles: synthesis and applications
- Sinusitis and nasal conditions
- Neurological Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Ginkgo biloba and Cashew Applications
- Adsorption and Cooling Systems
- Cholinesterase and Neurodegenerative Diseases
- Hormonal Regulation and Hypertension
- Cancer-related gene regulation
- Lung Cancer Research Studies
- bioluminescence and chemiluminescence research
- Carbon and Quantum Dots Applications
- PI3K/AKT/mTOR signaling in cancer
- Renin-Angiotensin System Studies
- Listeria monocytogenes in Food Safety
- Marine Biology and Environmental Chemistry
- Microbial Fuel Cells and Bioremediation
Qingdao University
2020-2025
Yuhuangding Hospital
2020-2025
Guizhou University of Finance and Economics
2025
Shanghai University
2024
Inner Mongolia University
2022-2024
Taizhou People's Hospital
2024
Nantong University
2024
National Neuroscience Institute
2024
Duke-NUS Medical School
2024
Shaanxi Provincial People's Hospital
2015-2023
Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p involved in HCC progression but its function multidrug still unclear. Here we aim to find out of inducing and underlying mechanisms transforming sensitive cell resistant cell.We detected expression PTEN multidrug-resistant line (Bel/5-FU) (Bel7402), para-carcinoma liver tissues through real-time PCR. Dual-luciferase reporter assay verified target miR-32-5p. Exosomes from were obtained confirmed...
Micro RNA ‐155‐5p (miR‐155‐5p) has been reported to play an oncogenic role in different human malignancies; however, its hepatocellular carcinoma ( HCC ) progression is not clearly understood. In this study, we used real‐time PCR 20 rats with chemically‐induced , 28 tissues, and the matched paracarcinoma cell lines determine expression patterns of miR‐155‐5p PTEN mRNA . Algorithm‐based experimental strategies, such as dual luciferase gene reporter assays, western blots were identify a...
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Accumulating studies have suggested that microRNA-760 (miR-760) plays an important role in chemoresistance of various cancer cells. However, whether miR-760 regulates the hepatocellular carcinoma (HCC) remains unclear. In this study, we found was decreased HCC cell lines, and doxorubicin (Dox) treatment significantly expression Overexpression sensitized cells to Dox-induced cytotoxicity apoptosis, whereas inhibition showed opposite effects. Notch1 predicted as a target gene miR-760....
Listeria monocytogenes (L. monocytogenes) is a food-borne pathogenic bacteria that frequently contaminates animal-derived food and low-temperature preserved food. Listeriosis caused by its infection has high mortality rate poses serious threat to human health. Therefore, it crucial establish sensitive, rapid easy-to-operate technique. In this study, Recombinase Aided Amplification (RAA) assisted CRISPR/Cas12a (RAA-CRISPR/Cas12a) fluorescence platform was established for highly sensitive...
Listeria monocytogenes is recognized as one of the primary pathogens responsible for foodborne illnesses. The ability L. to form biofilms notably increases its resistance antibiotics such ampicillin and tetracycline, making it exceedingly difficult eradicate. Residual bacteria within processing environment can contaminate food products, thereby posing a significant risk public health. In this study, we used crystal violet staining assess biofilm-forming capacity seven strains identified ATCC...
This paper examines the impact of common ownership on two-stage green innovation efficiency (GIE) listed companies in China. We find that significantly enhances both R&D (GRDE) and achievement transformation (GATE). Heterogeneity analysis indicates this is stronger more competitive environments. Meanwhile, enhancement effect significant GRDE for state-owned enterprises, but GATE non-state-owned enterprises. also GIE through internal governance (mitigating principal-agent issues fostering...
Background: A negative bronchial dilatation test (BDT) does not fully reflect the status of airway irreversibility in patients with severe obstructive or mixed ventilation dysfunction due to bronchospasm, mucus blockage, insensitivity bronchodilators, which will directly affect subsequent diagnosis and treatment those patients. Objective: We retrospectively examined feasibility using “intensive dilation test” (IBDT) for excluding false-negative BDT. Methods: analyzed clinical data 82 Allergy...
ABSTRACT Purpose An objective test for the auxiliary diagnosis of asthma is still lacking. The aim this study was to discriminate signatures via an untargeted metabolomic analysis exhaled breath condensate. Materials and Methods This enrolled 19 patients diagnosed with 23 healthy volunteers. Samples condensate (EBC) were collected from both groups. Untargeted analyses EBC used identify disease‐specific asthma. Result There 30 identifiable differentially expressed metabolites 7 disordered...
Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α) and interleukins (ILs). Interleukin-17 (IL-17) is hallmark cytokine produced CD4(+) Th17 cells, IL-17 mediates activation adaptive T-cell response inducing an environment. However, little known...
MicroRNA (miR)-146a, as an important immune regulatory factor with anti-inflammatory effect, plays a crucial role in T-cell (Tregs) differentiation and function allergic rhinitis (AR). The present study aimed to investigate the mechanism employed by miR-146a control Treg AR.Expression of STAT5b peripheral blood mononuclear cells (PBMCs) nasal mucosa from patients AR was detected qPCR Western blotting. Tregs were quantified flow cytometry knockdown or PBMCs. FOXP3, IL-10, TGF-β levels...
The 8-hydroxy-2′-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement endogenous oxidative DNA damage but might also be risk factor many diseases including cancer. Metal exposure may play important role in among children. However, few studies on urinary 8-OHdG and metals have been conducted children with acute leukemia. In present study, Ni were examined 116 leukaemia (94 lymphoid [ALL] 22 myeloid [AML]) 51 healthy child controls....
Background The mechanism of long noncoding RNAs (lncRNAs) involved in the development allergic rhinitis (AR) remains unclear. Objective We investigated by which differentially expressed lncRNAs contribute to pathogenesis AR. Methods Expression profiles and mRNAs were analyzed microarray detection from blood samples 3 AR patients control subjects, main verified quantitative real-time polymerase chain reaction (qRT-PCR) peripheral 16 18 subjects. GO (Gene_Ontology), Pathway, Disease analysis...
Enrofloxacin (ENR) is one of the most common drugs used in poultry production to treat bacterial diseases, and there a high risk drug interactions (DDIs) between polyether anticoccidial added feed over time. This may affect efficacy antibiotics or lead toxicity, posing potential environment food safety. study aimed investigate DDI ENR salinomycin (SAL) broilers mechanism their DDI. We found that SAL increased area under curve elimination half-life ciprofloxacin (CIP) by 1.3 2.4 times, 1.2...