A5031184650- Viral gastroenteritis research and epidemiology
- Nerve injury and regeneration
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Bioinformatics and Genomic Networks
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Aquaculture disease management and microbiota
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Alzheimer's disease research and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Glutathione Transferases and Polymorphisms
- Gene expression and cancer classification
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Lipids, and Metabolism
Tianjin Agricultural University
2025
Guangxi University
2021-2025
Yuhuangding Hospital
2024-2025
Qingdao University
2010-2025
Binzhou Medical University
2024-2025
Shenzhen Children's Hospital
2025
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Guangxi Veterinary Research Institute
2024
Guangxi Center for Disease Prevention and Control
2024
Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well neuropathic pain secondary lesions. Currently, effective treatments for PNI are still limited. For example, while growth factor (NGF) widely used the treatment of to promote regeneration, it also induces pain. Maresin 1 (MaR1) an anti-inflammatory proresolving mediator has potential regenerate tissue. We determined whether MaR1 able regeneration alleviating pain, be considered...
Preformed metal crowns (PMCs) and zirconia (ZCs) are commonly used for the treatment of primary molar caries. However, there have been no reports on factors influencing parental awareness, willingness to use these treatments, associated discomfort after crown placement in children.This study is first report preformed crowns, providing a reference prevention deciduous carious teeth. Parents whose children's posterior caries were restored with at Shenzhen Children's Hospital from October 2021...
ABSTRACT Purpose An objective test for the auxiliary diagnosis of asthma is still lacking. The aim this study was to discriminate signatures via an untargeted metabolomic analysis exhaled breath condensate. Materials and Methods This enrolled 19 patients diagnosed with 23 healthy volunteers. Samples condensate (EBC) were collected from both groups. Untargeted analyses EBC used identify disease‐specific asthma. Result There 30 identifiable differentially expressed metabolites 7 disordered...
Rab GTPases play a crucial role in facilitating the transportation of vesicles during process fungal biogenesis. Currently, there is limited understanding regarding specific biological functions small GTPase elements within Fusarium oxysporum . In this study, we examined three proteins FoRab5, FoRab7, and FoRab8 Foc, which exhibit homology to protein family found Saccharomyces cerevisiae addition, also employed PEG-mediated homologous recombination approach create deletion mutants...
Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in female breast. In epidemiological studies, a high percentage MD confers four to six fold risk elevation developing breast cancer, even after adjustment for other known cancer factors. However, biologic correlates are little known. Gene expression analysis using whole genome arrays was performed on biopsies 143 women; 79 women with no...
S-phase-associated kinase protein-2 (Skp2) is involved in ubiquitination and proteasome-mediated degradation of p27kip1, which plays an important role mammalian cell-cycle regulation neurogenesis the developing central nervous system. To investigate their expression function system injury repair, we used a brain-penetrating model adult rats. Western blot analysis showed significant downregulation p27kip1 concomitant upregulation Skp2 following brain injury, profiles were temporally...
Fungal pathogens can invade not only the fruit peel but also outer part of mesocarp, limiting efficacy fungicides. In this study, relationships between fungicide structure, diffusion capacity and in vivo were evaluated for first time. The from pear to mesocarp 11 antifungal compounds, including p-aminobenzoic acid, carbendazim, difenoconazole, dipicolinic flusilazole, gentamicin, kojic prochloraz, quinolinic thiophanate methyl thiram was screened. obtained results indicated that size...
Evidence for the evolutionary maintenance of a hairpin structure possibly involved in intron processing had been found 1 alcohol dehydrogenase gene (Adh) diverse Drosophila species. In this study, putative was evaluated systematically melanogaster by elimination either side stem using site-directed mutagenesis. The effects these mutations and compensatory double mutant on splicing efficiency ADH protein production were assayed Schneider L2 cells germ-line transformed adult flies. Mutations...
SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing with many unknown biological functions. Recently emerging evidence has revealed that it novel regulator of the p53 pathway, which required for neurite outgrowth and regeneration. Here we present SCYL1BP1 inhibits nerve growth factor-mediated in PC12 cells affects morphogenesis primary cortical neurons by strongly decreasing level vitro, all depends on SCYL1BP1's domain. Exogenous...
At the beginning of spinal cord injury (SCI), expression EphB2 on fibroblasts and ephrin-B2 astrocytes increased simultaneously their binding triggers formation astroglial-fibrotic scars, which represent a barrier to axonal regeneration. In present study, we sought suppress scar promote recovery from SCI by targeting in vivo.The female rats models were used vivo experiments subsequently injecting with shRNA lentiviruses. The effect knockdown was evaluated at 14 days after injury. repair...
The Mammalian orthoreovirus (MRV) infects various mammals, including humans, and is linked to gastrointestinal, respiratory, neurological diseases. A recent outbreak in Liuzhou, Guangxi, China, led the isolation of a new MRV strain, GXLZ2301, from fecal samples. This strain replicates multiple cell lines forms lattice-like structures. Infected cells exhibit single-cell death syncytia formation. virus’s titers peaked at 10 7.2 TCID 50 /0.1 mL PK-15 BHK cells, with lowest 3.88 TCID50/0.1 A549...
Summary Aims Astroglial‐fibrotic scar formation following central nervous system injury can help repair blood‐brain barrier and seal the lesion, whereas it also represents a strong for axonal regeneration. Intensive preclinical efforts have been made to eliminate/reduce inhibitory part and, in meantime, preserve beneficial role of astroglial‐fibrotic scar. Methods In this study, we established an vitro system, which coculture astrocytes meningeal fibroblasts was treated with exogenous...
Duck hepatitis A virus 3 (DHAV-3) is a wild endemic virus, which seriously endangers the duck industry in China. The present study aims to elucidate mechanism of resistance DHAV-3 infection. Both resistant and susceptible ducks were challenged with DHAV-3, dynamics liver histopathological features transcriptome analyzed at 6, 12, 15, 24 h post-infection (hpi). serum biochemical indices (ALT AST) estimate status injury. result showed that injury was more serious compared throughout four time...
A body of evidence has suggested that tissue-engineered nerve grafts hold promise for the surgical repair spinal cord injuries. In this study, a novel graft was prepared to be implantated into 5 mm gap which caused by complete transection rat cord. The featured incorporation neurotrophin-3 chitosan-based tube scaffold with cord-mimicking, partition-type architecture, based on morphometric insights normal anatomy. set behavioral, functional, and histological examinations were carried out...
Enterovirus G (EV-G) infects porcine populations worldwide and the infections are generally asymptomatic, with insertion of papain-like cysteine protease gene (PLCP) increasing potential public health threats. However, genetic pathogenic characteristics EV-G itself not fully understood as yet. In present study, one strain, named CH/17GXQZ/2017, was isolated purified from piglets diarrheic symptoms Guangxi Province, China. This strain produced stable cytopathic effects on Marc-145 cells a...