A5007767899- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Neurological disorders and treatments
- Animal Disease Management and Epidemiology
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- Respiratory viral infections research
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Viral Infections and Vectors
- Adipokines, Inflammation, and Metabolic Diseases
- Vector-Borne Animal Diseases
- Cardiac Structural Anomalies and Repair
- Atherosclerosis and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- interferon and immune responses
- Cardiac Fibrosis and Remodeling
- Immune Response and Inflammation
- Cardiovascular Function and Risk Factors
Guangxi University
2016-2025
Guangxi Veterinary Research Institute
2022-2025
Guangxi Center for Disease Prevention and Control
2022-2025
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Tropical Crops Genetic Resources Institute
2023-2025
Chinese Academy of Tropical Agricultural Sciences
2023-2025
University of Pittsburgh
2025
Central South University
2025
Renji Hospital
2024-2025
Background: Left bundle branch pacing (LBBP) is a novel method and has been observed to have low stable thresholds in prior small short-term studies. The objective of this study was evaluate the feasibility safety LBBP large consecutive diverse group patients with long-term follow-up. Methods: This prospectively enrolled 632 pacemaker attempted from April 2017 July 2019. Pacing parameters, complications, ECG, echocardiographic measurements were assessed at implant during follow-up 1, 6, 12,...
Objectives His bundle pacing (HBP) can potentially correct left branch block (LBBB). We aimed to assess the efficacy of HBP LBBB and long-term clinical outcomes with in patients heart failure (HF). Methods This is an observational study HF typical who were indicated for therapy consecutively enrolled from one centre. Permanent leads implanted if correction threshold was <3.5V/0.5 ms or 3.0 V/1.0 ms. Pacing parameters, ventricular ejection fraction (LVEF), end-systolic volume (LVESV) New...
Abstract Conduction system pacing (CSP) has emerged as a more physiological alternative to right ventricular and is also being used in selected cases for cardiac resynchronization therapy. His bundle was first introduced over two decades ago its use risen the last five years with advent of tools which have facilitated implantation. Left branch area recent but adoption growing fast due wider target excellent electrical parameters. Nevertheless, any intervention, proper technique prerequisite...
Background Clinical benefits from His bundle pacing ( HBP ) in heart failure patients with preserved and reduced left ventricular ejection fraction are still inconclusive. This study evaluated clinical outcomes of permanent atrial fibrillation narrow QRS who underwent atrioventricular node ablation for symptoms despite rate control by medication. Methods Results The enrolled 52 consecutive attempted symptomatic fibrillation. Echocardiographic end‐diastolic dimension, New York Heart...
This study sought to evaluate the safety and efficacy of rosuvastatin in preventing contrast-induced acute kidney injury (CI-AKI) patients with diabetes mellitus (DM) chronic disease (CKD).CI-AKI is an important complication after contrast medium injection. While small studies have shown positive results statin therapy, role therapy prevention CI-AKI remains unknown.We randomized 2,998 type 2 DM concomitant CKD who were undergoing coronary/peripheral arterial angiography or without...
Excessive Ang II (angiotensin II) levels lead to a profibrotic and hypertrophic milieu that produces deleterious remodeling dysfunction in hypertension-associated heart failure. Agents disrupt II-induced cardiac may have clinical utility the treatment of failure.We examined potential effect celastrol-a bioactive compound derived from Celastraceae family-on dysfunction.In rat primary cardiomyocytes H9C2 (rat cardiomyocyte-like H9C2) cells, celastrol attenuates cellular hypertrophy fibrotic...
Emodin has recently been reported to have a powerful antiinflammatory effect, protecting the myocardium against ischemia/reperfusion (I/R) injury. Pyroptosis is proinflammatory programmed cell death that related many diseases. The present study investigated effect of emodin on pyroptosis in cardiomyocytes.Sprague Dawley rats were randomly divided into sham, I/R, and I/R+Emodin groups. I/R model was subjected 30 minutes' ligation left anterior descending coronary artery, followed by 2 hours...
Conduction system pacing (CSP) has emerged as a more physiological alternative to right ventricular and is also being used in selected cases for cardiac resynchronization therapy. His bundle was first introduced over two decades ago its use risen the last years with advent of tools which have facilitated implantation. Left branch area recent but adoption growing fast due wider target excellent electrical parameters. Nevertheless, any intervention, proper technique prerequisite safe effective...
Background: Pathological cardiac hypertrophy can lead to heart failure and is one of the leading causes death globally. Understanding molecular mechanism pathological will contribute treatment failure. DUBs (deubiquitinating enzymes) are essential pathophysiology by precisely controlling protein function, localization, degradation. This study set out investigate role a DUB, USP25 (ubiquitin-specific peptidase 25), in hypertrophy. Methods: The myocardial was evaluated murine cardiomyocytes...
Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is vital factor determining fate atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis programmed cell death, characterized by membrane pore formation inflammatory release.
AimsTo test the hypothesis that increasing age in patients presenting with high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS) does not adversely influence benefit of an early invasive strategy on major adverse events at 6 months.
Abstract Introduction Left bundle branch pacing (LBBP) has recently been reported to maintain left ventricular electrical synchrony with a low and stable threshold. However, the electrocardiogram (ECG) definitions of LBBP have not well established. We report four cases show characteristics ECG intracardiac electrogram (EGM) in LBBP. Methods Results Four patients, two an atrioventricular block (AVB) (LBBB), were included study. was performed ECGs EGMs collected compared at different outputs....
Aims: In the NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is closely related to progression of atherosclerosis. This study aimed assess effects curcumin on NLRP3 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism. Methods: Human monocytic THP-1 cells were pretreated with for 1 h subsequently induced PMA 48 h. Total protein was collected Western blot analysis. Cytokine interleukin (IL)-1β release nuclear factor...