A5100684984- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Angiogenesis and VEGF in Cancer
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Electrospun Nanofibers in Biomedical Applications
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Protease and Inhibitor Mechanisms
- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Autophagy in Disease and Therapy
- Polymer Surface Interaction Studies
- Connexins and lens biology
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
Sir Run Run Shaw Hospital
2016-2025
Zhejiang University
2016-2025
Zhejiang Medicine (China)
2024-2025
National University of Singapore
2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2024
Zhongshan Hospital
2012-2024
Fudan University
2012-2024
Sun Yat-sen University
2012-2024
Sanya Central Hospital
2023
Regenerative Medicine Institute
2023
Stromal cell-derived factor (SDF)-1α, a member of the chemokine CXC subfamily, plays an important role in regulation variety cellular functions endothelial progenitor cells such as cell migration, proliferation, survival and angiogenesis. However, there is relatively little information linking individual signaling pathways mediated by SDF-1α cells. In our study, we showed that expressed CXCR4 reverse transcription polymerase chain reaction flow cytometric analysis. Functional analysis...
The intention of the PEPCAD China ISR (A Prospective, Multicenter, Randomized Trial Paclitaxel-Coated versus Paclitaxel-Eluting Stent for Treatment Drug-Eluting In-Stent Restenosis) was to demonstrate efficacy paclitaxel-coated balloon (PCB) angioplasty in a non-European patient population with coronary drug-eluting stent in-stent restenosis (DES-ISR). treatment DES-ISR is still challenging no established best strategy. Moreover, there study on effect PCB Chinese population. 220-patient...
Atherosclerosis, as a life-threatening cardiovascular disease with chronic inflammation and abnormal lipid enrichment, is often difficult to treat timely due the lack of obvious symptoms. In this work, theranostic nanoplatform constructed for noninvasive in vivo diagnosis, plaque-formation inhibition, lesion reversal atherosclerosis. A three-in-one therapeutic complex packaged along polymeric photoacoustic probe into nanoparticles named PLCDP@PMH, which indicates an atherosclerosis-targeting...
Abstract Vascular restenosis after balloon dilation is largely caused by the over‐proliferation of smooth muscle cells, which triggered and exacerbated local excessive inflammation oxidative stress. The inflammatory stress cause tissue/cell damage, hamper endothelial functions, worsen intimal hyperplasia restenosis. A high level reactive oxygen species (ROS) overproduction regarded as main culprit. Therefore, efficiently inhibiting ROS over‐production or weightily depleting them great...
Abstract Mesenchymal stem cell‐derived extracellular vesicle (MSC‐EV) is shown to promote cardiac repair, however, it still falls short in initiating myocardia proliferation restart. In this regard, ROS‐induced DNA damage and responses are the culprit of cellcycle arrest. Here, work constructs a hybrid that composed MSC macrophage membranes encompasses MitoN, ROS scavenger, boost healing heart. The NAD(P)H mimic, could target mitochondrial eliminate resuming arrested cell cycle. (N@MEV)...
Cardiac remodeling in heart failure involves macrophage-mediated immune responses. Recent studies have shown that a PRR (pattern recognition receptor) called dectin-1, expressed on macrophages, mediates proinflammatory Whether dectin-1 plays role pathological cardiac is unknown. Here, we identified potential of this disease.To model aberrant remodeling, utilized mouse models chronic Ang II (angiotensin II) infusion. In model, assessed the through using D1KO (dectin-1 knockout) mice and bone...
Abstract Myocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation ferritin, resulting in elevated levels free iron heart and thereby inducing ferroptosis. Targeting myocardial ferroptosis through chelation excess has therapeutic potential for MI treatment. However, post ischemic injury areas using conventional iron‐specific chelators is hindered by ineffective intracellular chelation, rapid clearance, high systemic toxicity. A chitosan‐desferrioxamine...
Background The FAVOR III (Comparison of Quantitative Flow Ratio Guided and Angiography Percutaneous Intervention in Patients With Coronary Artery Disease) China trial reported improved clinical outcomes with percutaneous coronary intervention guided by quantitative flow ratio (QFR) compared angiography. Whether these benefits also apply for patients presenting “uncertainty‐zone” lesions intermediate physiological significance is uncertain. This study aims to examine the impact QFR guidance...
Backgrounds: Autophagy is an important process in the pathogenesis of diabetes and plays a critical role maintaining cellular homeostasis. However, autophagic response its mechanism diabetic vascular endothelium remain unclear. Methods Results: We studied high-glucose-induced renin-angiotensin system (RAS)-mitochondrial damage effect on endothelial cells. With regard to therapeutics, we investigated beneficial angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II type 1 receptor...
Metabolic remodeling precedes most alterations during cardiac hypertrophic growth under hemodynamic stress. The elevation of glucose utilization has been recognized as a hallmark metabolic remodeling. However, its role in and heart failure response to pressure overload remains be fully illustrated. Here, we aimed dissect the PKM1 (pyruvate kinase muscle isozyme 1) regulation overload.
Systemic immune-inflammation index (SII) is an emerging indicator and correlated to the incidence of cardiovascular diseases. This study aimed explore association between SII contrast-induced acute kidney injury (CI-AKI).In this retrospective cross-sectional study, 4,381 subjects undergoing coronary angiography (CAG) were included. defined as neutrophil count × platelet count/lymphocyte count. CI-AKI was determined by elevation serum creatinine (Scr). Multivariable linear logistic regression...
Abstract Aging is a major risk for developing cardiac and skeletal muscle dysfunction, yet the underlying mechanism remains elusive. Here we demonstrated that mitochondria-associated endoplasmic reticulum membranes (MAMs) in rat heart were disrupted during aging. Using quantitative morphological analysis, showed mitochondria-endoplasmic contacts (MERCs) reduced by half over lifespan with an early onset of accelerated thickening clefts. The ultrastructural changes further validated proteomic...
Abstract Cuproptosis is a recently discovered programmed cell death pattern that affects the tricarboxylic acid (TCA) cycle by disrupting lipoylation of pyruvate dehydrogenase (PDH) complex components. However, role cuproptosis in progression ischemic heart failure (IHF) has not been investigated. In this study, we investigated expression 10 cuproptosis‐related genes samples from both healthy individuals and those with IHF. Utilizing these differential gene expressions, developed risk...
Abstract The left atrial appendage (LAA) occluder is an important medical device for closing the LAA and preventing stroke. device‐related thrombus (DRT) prevents implantation of in exerting desired therapeutic effect, which primarily caused by delayed endothelialization occluder. Functional coatings are effective strategy accelerating occluders. However, surface area particularly large structurally complex, subjected to a shear friction sheath during implantation, poses significant...