A5047677442- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Cytokine Signaling Pathways and Interactions
- Neonatal Health and Biochemistry
- Autophagy in Disease and Therapy
- Biomarkers in Disease Mechanisms
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Biochemical and Molecular Research
- Lipid metabolism and disorders
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Pain Management
- Cardiovascular Disease and Adiposity
- RNA regulation and disease
- RNA Research and Splicing
- Diet, Metabolism, and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Ischemia and Reperfusion
Tianjin University of Traditional Chinese Medicine
2025
Dongguan University of Technology
2021-2024
City Of Hope National Medical Center
2022-2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2024
Guangzhou University
2024
City of Hope
2024
The University of Texas Southwestern Medical Center
2013-2023
RELX Group (United States)
2019
Southwestern Medical Center
2012-2018
Dermal adipose tissue (also known as dermal white and herein referred to dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate mature adipocytes origin rapidly reappearing at different stages remain unclear. Here, we isolated characterized fat cellular molecular level. Together with dWAT's dynamic responses external stimuli, established that are a distinct class high plasticity. By combining pulse-chase lineage tracing single-cell...
In yeast Saccharomyces cerevisiae , Ash1p, a protein determinant for mating-type switching, is segregated within the daughter cell nucleus to establish asymmetry of HO expression. The accumulation Ash1p results from ASH1 mRNA that sorted as ribonucleoprotein particle (mRNP or locasome) distal tip bud where translation occurs. To study mechanism regulating translation, we isolated locasome and characterized associated proteins by MALDI-TOF. One these was Puf6p, new member PUF family highly...
The adipocyte-specific secretory molecule adiponectin has found widespread acceptance as a systemic marker that effectively integrates number of signals associated with metabolic dysfunction at the level adipose tissue. widely used aP2 promoter cassette, which is frequently chosen to achieve expression transgenes, conveys transcription in cell types other than adipocytes, such macrophages and cardiomyocytes. To improve our ability drive transgene more way, we aimed define minimal segment...
Abstract Purpose: Adipocytes represent one of the most abundant constituents mammary gland. They are essential for tumor growth and survival. Metabolically, more important fat-derived factors (“adipokines”) is adiponectin (APN). Serum concentrations APN negatively correlate with body mass index insulin resistance. To explore association breast cancer angiogenesis, we took an in vivo approach aiming to study its role mouse virus (MMTV)-polyoma middle T antigen (PyMT) model. Experimental...
Postprandially, the liver experiences an extensive metabolic reprogramming that is required for switch from glucose production to assimilation. Upon refeeding, unfolded protein response (UPR) rapidly, though only transiently, activated. Activation of UPR results in a cessation translation, increased chaperone expression, and ER-mediated degradation, but it not clear how involved postprandial alternate fuel sources. inositol-requiring enzyme 1 (IRE1) branch signaling pathway triggers...
Uridine, a pyrimidine nucleoside present at high levels in the plasma of rodents and humans, is critical for RNA synthesis, glycogen deposition, many other essential cellular processes. It also contributes to systemic metabolism, but underlying mechanisms remain unclear. We found that uridine are regulated by fasting refeeding mice, rats, humans. Fasting increases levels, this increase relies largely on adipocytes. In contrast, reduces through biliary clearance. Elevation required drop body...
The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress response, and cell growth. However, its contribution to cardiac hypertrophic growth heart failure remains incompletely understood. Here, we show that the HBP is induced cardiomyocytes during Overexpression of Gfat1 (glutamine:fructose-6-phosphate amidotransferase 1), rate-limiting enzyme HBP, promotes cardiomyocyte On other hand, inhibition significantly blunts phenylephrine-induced cultured...
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association circulating adiponectin with healthspan lifespan. However, direct effects on promoting lifespan remain unexplored. Here, we are using an null mouse transgenic overexpression model. We directly assessed aging process found that mice display exacerbated age-related glucose lipid metabolism disorders. Moreover, significantly...
The integrated stress response (ISR) is an evolutionarily conserved process to cope with intracellular and extracellular disturbances. Myocardial infarction a leading cause of death worldwide. Coronary artery reperfusion, the most effective means mitigate cardiac damage myocardial infarction, causes additional reperfusion injury. This study aimed investigate role ISR in ischemia/reperfusion (I/R).Cardiac-specific gain- loss-of-function approaches for were used vivo. I/R was achieved by...
Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with concentration higher than the other nucleosides. As simple metabolite, uridine plays pivotal role various biological processes. In addition to nucleic acid synthesis, critical glycogen synthesis through formation of diphosphate glucose which promotes production UDP-GlcNAc hexosamine biosynthetic pathway supplies for O-GlcNAcylation. This process can regulate protein modification affect its function. Moreover, has...
Translational repression during mRNA transport is essential for spatial restriction of protein production. In the yeast Saccharomyces cerevisae , silencing ASH1 before it localized to bud cortex in late anaphase critical asymmetric segregation Ash1p daughter cell nucleus. Puf6p, an mRNA-binding protein, has been implicated this process as a translational repressor, but underlying mechanism unknown. Here, we used extract-based vitro translation assays, which recapitulate and phosphorylation,...
Despite many angiogenic factors playing crucial roles in metabolic homeostasis, effects of angiopoietin-2 (ANG-2) adipose tissue (AT) remain unclear. Utilizing a doxycycline-inducible AT-specific ANG-2 overexpression mouse model, we assessed the AT expansion upon high-fat diet (HFD) challenge. is significantly induced, with subcutaneous white (sWAT) displaying highest expression. overexpressing mice show increased sWAT vascularization and are resistant to HFD-induced obesity. In addition,...
The heart manifests hypertrophic growth in response to high blood pressure, which may decompensate and progress failure under persistent stress. Metabolic remodeling is an early event this process. However, its role remains be fully characterized. Here, we show that lactate dehydrogenase A (LDHA), a critical glycolytic enzyme, elevated the hemodynamic Cardiomyocyte-restricted deletion of LDHA leads defective cardiac by pressure overload. Silencing cultured cardiomyocytes suppresses cell from...
The goal was to connect elements of idiopathic pulmonary fibrosis (IPF) pathogenesis, including chronic endoplasmic reticulum stress in respiratory epithelia associated with injury/inflammation and remodeling, distal airway mucus obstruction honeycomb cyst formation accumulation MUC5B (mucin 5B), associations between IPF risk polymorphisms the
Metabolic remodeling precedes most alterations during cardiac hypertrophic growth under hemodynamic stress. The elevation of glucose utilization has been recognized as a hallmark metabolic remodeling. However, its role in and heart failure response to pressure overload remains be fully illustrated. Here, we aimed dissect the PKM1 (pyruvate kinase muscle isozyme 1) regulation overload.
Inflammation plays a critical role in the pathology of obesity-linked insulin resistance and is mechanistically linked to effects macrophage-derived cytokines on adipocyte energy metabolism, particularly that mitochondrial branched-chain amino acid (BCAA) tricarboxylic (TCA) pathways. To address inflammation metabolism adipocytes, we used high fat-fed C57BL/6J mice lean controls measured down-regulation genes BCAA TCA cycle selectively visceral but not subcutaneous adipose tissue, brown fat,...