A5100719877- Advanced NMR Techniques and Applications
- Mitochondrial Function and Pathology
- Chemical Synthesis and Reactions
- Advanced Photocatalysis Techniques
- Sulfur-Based Synthesis Techniques
- Organ Transplantation Techniques and Outcomes
- Photochemistry and Electron Transfer Studies
- Electron Spin Resonance Studies
- Surfactants and Colloidal Systems
- Transplantation: Methods and Outcomes
- Copper-based nanomaterials and applications
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Gas Sensing Nanomaterials and Sensors
- Enzyme Structure and Function
- Cardiac Ischemia and Reperfusion
- Nanoparticles: synthesis and applications
- Mycotoxins in Agriculture and Food
- Spectroscopy and Quantum Chemical Studies
- Metabolomics and Mass Spectrometry Studies
Advanced Imaging Research (United States)
2018-2025
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2023-2024
Shoolini University
2019-2024
Sriram Chandra Bhanja Medical College Hospital
2024
VA North Texas Health Care System
2023
All India Institute of Medical Sciences Jodhpur
2020
Pokhara University
2018
Jawaharlal Nehru University
2012-2018
Aligarh Muslim University
2011-2017
Micropeptide regulator of β-oxidation (MOXI) is a conserved muscle-enriched protein encoded by an RNA transcript misannotated as non-coding. MOXI localizes to the inner mitochondrial membrane where it associates with trifunctional protein, enzyme complex that plays critical role in fatty acid β-oxidation. Isolated heart and skeletal muscle mitochondria from knockout mice exhibit diminished ability metabolize acids, while transgenic overexpression leads enhanced Additionally, hearts...
To evaluate the antioxidant activity of aqueous extract Moringa oleifera (M. oleifera) young leaves by in vivo as well vitro assays.In study included estimation total phenolic, flavonol, flavonoid and power (FRAP assay). In addition, was done with identified most effective dose 200 mg/kg its lyophilized powder on normal diabetic rats. Its effect different oxidative free radical scavenging enzymes,viz, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), lipid peroxide...
Neurodegenerative diseases pose a growing global health challenge, with limited effective therapeutic options. Mitochondrial dysfunction, oxidative stress, neuroinflammation, apoptosis, and autophagy are common underlying mechanisms in these diseases. Thymol is phenolic monoterpene compound that has gained attention for its diverse biological properties, including antioxidant, anti-inflammatory, immunomodulatory activities. supplementation could provide potential neuroprotection improve...
The heart manifests hypertrophic growth in response to high blood pressure, which may decompensate and progress failure under persistent stress. Metabolic remodeling is an early event this process. However, its role remains be fully characterized. Here, we show that lactate dehydrogenase A (LDHA), a critical glycolytic enzyme, elevated the hemodynamic Cardiomyocyte-restricted deletion of LDHA leads defective cardiac by pressure overload. Silencing cultured cardiomyocytes suppresses cell from...
Metabolic remodeling precedes most alterations during cardiac hypertrophic growth under hemodynamic stress. The elevation of glucose utilization has been recognized as a hallmark metabolic remodeling. However, its role in and heart failure response to pressure overload remains be fully illustrated. Here, we aimed dissect the PKM1 (pyruvate kinase muscle isozyme 1) regulation overload.
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity,...
Quinocetone (QCT), a member of the quinoxaline 1,4-di-N-oxides (QdNOs) family, can cause genotoxicity and hepatotoxicity, however, precise molecular mechanisms QCT are unclear. This present study investigated protective effect quercetin on QCT-induced cytotoxicity underlying in human L02 HepG2 cells. The results showed that treatment (at 7.5–30 μM) significantly improved oxidative damage Meanwhile, at 30 μM inhibited loss mitochondrial membrane potential, an increase expression CytC protein...
Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated obesity may contribute to excess fat accumulation. Glycine glutamate, addition cysteine, components of glutathione, major antioxidant liver. In principle, glycerol could be incorporated into glutathione via TCA cycle or 3-phosphoglycerate, but it unknown whether contributes hepatic de novo biosynthesis.