A5015600636- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- Inhalation and Respiratory Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Traditional Chinese Medicine Analysis
- Virus-based gene therapy research
- Mycotoxins in Agriculture and Food
- Chemotherapy-induced organ toxicity mitigation
- Drug Solubulity and Delivery Systems
- Bioactive Compounds and Antitumor Agents
- Drug-Induced Hepatotoxicity and Protection
- Nanoparticle-Based Drug Delivery
- Antibiotic Resistance in Bacteria
- Animal Virus Infections Studies
- Acute Kidney Injury Research
- Natural product bioactivities and synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Microbial infections and disease research
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
China Agricultural University
2009-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Sanya University
2024-2025
Xinjiang Agricultural University
2024
Qingdao Agricultural University
2013-2020
Continental (United States)
2012
China Pharmaceutical University
1992
Abstract Sharing of genetic elements among different pathogens and commensals inhabiting same hosts environments has significant implications for antimicrobial resistance (AMR), especially in settings with high exposure. We analysed 661 Escherichia coli Salmonella enterica isolates collected within across environments, 10 Chinese chicken farms over 2.5 years using data-mining methods. Most possessed the clinically relevant AMR-carrying mobile (plasmids: 70.6%, transposons: 78%), which also...
China is the largest global consumer of antimicrobials and improving surveillance methods could help to reduce antimicrobial resistance (AMR) spread. Here we report ten large-scale chicken farms four connected abattoirs in three Chinese provinces over 2.5 years. Using a data mining approach based on machine learning, analysed 461 microbiomes from birds, carcasses environments, identifying 145 potentially mobile antibiotic genes (ARGs) shared between chickens environments across all farms. A...
The present study compared the effects of soybean meal fermented by three different probiotics organisms with non-fermented on growth performance, serum parameters, immune chemistry and intestinal morphology in weaned piglets. One hundred forty-four 35-day old crossbred (Duroc × Landrace Yorkshire) piglets were randomly allocated into four dietary treatments (n = 36 per group) containing 0, 5, 10 15% meal. fed showed an increase (p < 0.05) average daily weight gain a reduction feed...
Liver fibrosis and hepatocellular carcinogenesis secondary to liver are serious diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served as successful treatments for many types of injury including although the molecular mechanisms unknown at present. To investigate effect MFAEs in alleviating acute chronic tried decipher underlying mechanism. Mice were divided into 5 groups (n = 8) (groups: control, 0.3% CCl4, bifendate (BD), 100 200 mg/kg MFAEs, 7 d) 10% BD,...
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity,...
Nephrotoxicity is the major limiting factor for clinical use of vancomycin (VCM) treatment serious infections caused by multiresistant Gram-positive bacteria. This study investigated renal protective activity rutin in a rat model VCM-induced kidney injury male Wistar rats.
Gentamicin is an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections that possesses considerable nephrotoxicity. Oxymatrine a phytochemical with the ability counter gentamicin toxicity. We investigated effects and protective mechanism of oxymatrine in rats. The experimental groups were as follows: Control, only group (100 mg/kg/d), mg/kg/d) plus (n = 10). All rats treated for seven continuous days. results indicated alleviated gentamicin-induced kidney injury,...
Pingwei San (PWS) has been used for more than a thousand years as traditional Chinese medicine prescription treating spleen-deficiency diarrhea (SDD). Nevertheless, the exact mechanism by which it exerts its antidiarrheal effects remains unclear. The objective of this investigation was to explore efficacy PWS and action in SDD induced Rhubarb. To end, UHPLC-MS/MS identify chemical composition PWS, while body weight, fecal moisture content, colon pathological alterations were evaluate on...
Background: Cold-dampness diarrhea (CDD) is a common gastrointestinal disorder in children, characterized by and intestinal barrier dysfunction. Weiling decoction (WLD) frequently used clinical practice to treat CDD, condition triggered multiple factors. However, the molecular mechanisms underlying its therapeutic effects remain poorly understood. Objectives: This study aimed evaluate efficacy of WLD treating CDD elucidate potential mechanisms. Methods: UPLC-HRMS/MS was employed identify...
Abstract Porcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive. Our in vitro study revealed that ergosterol peroxide (EP) from mushroom Cryptoporus volvatus has anti-PDCoV properties. The aim of this evaluate potential EP as treatment for PDCoV vivo and elucidate possible mechanisms. Seven-day-old piglets were infected by oral administration presence...
Atherosclerosis, a chronic inflammatory disease, is major contributor to cardiovascular diseases. Ursolic acid (UA) phytonutrient with widely biological effects including anti-oxidative, anti-inflammatory, and so on. At present, the effect of UA on atherosclerosis mechanism action are still obscure. This study focused investigating both in vivo vitro. We first selected LOX-1 as our target, which was reckoned new promising receptor for treating atherosclerosis. The evaluation vitro suggested...