A5057765272- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Biochemical effects in animals
- Diet, Metabolism, and Disease
- Muscle metabolism and nutrition
- Fluid Dynamics and Turbulent Flows
- Circadian rhythm and melatonin
- Gut microbiota and health
- Hypothalamic control of reproductive hormones
- Nanofluid Flow and Heat Transfer
- Dietary Effects on Health
- Metabolism, Diabetes, and Cancer
- Neurobiology and Insect Physiology Research
- Parathyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Lattice Boltzmann Simulation Studies
- Stress Responses and Cortisol
- Diet and metabolism studies
- Digestive system and related health
- Calcium signaling and nucleotide metabolism
The University of Texas Southwestern Medical Center
2015-2025
Southwestern Medical Center
2013-2025
Osaka Metropolitan University
2024
The University of Texas at San Antonio
2017-2023
The University of Texas Health Science Center at San Antonio
2017-2023
Hokkaido University
2015-2022
National Institute of Technology, Miyakonojo College
2018-2019
The University of Texas Health Science Center at Houston
2018-2019
Integrative Health Technologies (United States)
2018-2019
Urology San Antonio
2019
Leptin monotherapy reverses the deadly consequences and improves several of metabolic imbalances caused by insulin-deficient type 1 diabetes (T1D) in rodents. However, mechanism(s) underlying these effects is totally unknown. Here, we report that intracerebroventricular (icv) infusion leptin lethality greatly hyperglycemia, hyperglucagonemia, hyperketonemia, polyuria insulin deficiency mice. Notably, icv administration leads to increased body weight while suppressing food intake, thus...
Obesity, diabetes, and other metabolic complications are growing concerns for public health could lead to detrimental life-threatening conditions. Neurons whose activities required energy glucose homeostasis found in a number of hypothalamic nuclei. In the early twentieth century, ventral medial nucleus hypothalamus (VMH) was first site reported play prominent role regulation through control food intake expenditure. Recent studies using sophisticated genetic tools have further highlighted...
Leptin is critical for energy balance, glucose homeostasis, and metabolic neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons express leptin receptors (LEPRs). However, previous studies have used prenatal genetic manipulations, which may be subject developmental compensation. Here, we tested the direct contribution of POMC expressing LEPRs in regulating homeostasis secretion during fasting using a...
Abstract Resveratrol is a natural polyphenolic compound that activates nicotinamide adenosine dinucleotide-dependent deacetylase SIRT1. has recently been shown to exert potent antidiabetic actions when orally delivered animal models of type 2 diabetes. However, the tissue(s) mediating these beneficial effects unknown. Because SIRT1 expressed in central nervous system (CNS) neurons known control glucose and insulin homeostasis, we hypothesized resveratrol are mediated by brain. Here, report...
Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances of enormous medical significance. Sirt6 loss- gain-of-function studies have generated confounding data regarding the role this sirtuin on energy glucose homeostasis, leaving unclear whether activation or inhibition SIRT6 may be beneficial and/or T2DM.To address issues, we developed studied a mouse model...
Background: Inorganic phosphate (Pi) is used extensively as a preservative and flavor enhancer in the Western diet. Physical inactivity, common feature of societies, associated with increased cardiovascular morbidity mortality. It unknown whether dietary Pi excess contributes to exercise intolerance physical inactivity. Methods: To determine an association between activity humans, we assessed relationship serum actigraphy-determined level, well left ventricular function by cardiac magnetic...
The use of genetically engineered tools, including combinations Cre-LoxP and Flp-FRT systems, enable the interrogation complex biology. Steroidogenic factor-1 (SF-1) is expressed in ventromedial hypothalamic nucleus (VMH). Development genetic such as mice expressing Flp recombinase (Flp) SF-1 neurons ( Sf-1 -Flp), will be useful for future studies that unravel physiology regulated by VMH. Here, we developed characterized -Flp demonstrated its utility. sequence was inserted into locus with...
The use of genetically engineered tools, including combinations Cre-LoxP and Flp-FRT systems, enable the interrogation complex biology. Steroidogenic factor-1 (SF-1) is expressed in ventromedial hypothalamic nucleus (VMH). Development genetic such as mice expressing Flp recombinase (Flp) SF-1 neurons (Sf-1-Flp), will be useful for future studies that unravel physiology regulated by VMH. Here, we developed characterized Sf-1-Flp demonstrated its utility. sequence was inserted into Sf-1 locus...
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role the CNS in regulation of metabolism context exercise remains less clear. Here, using genetically engineered mice we assessed requirement steroidogenic factor-1 (SF-1) expression neurons ventromedial hypothalamic nucleus (VMH) mediating effects on We found that VMH-specific deletion SF-1 blunts (a) reductions fat...
Skeletal muscle plays a central role in the control of metabolism and exercise tolerance. Analysis enhancers activated after mice revealed orphan nuclear receptor NURR1/NR4A2 as prominent component exercise-responsive enhancers. We show that enhances expression NURR1, transgenic overexpression NURR1 skeletal physical performance mice. is also sufficient to prevent hyperglycemia hepatic steatosis, by enhancing glucose uptake storage glycogen. Furthermore, treatment obese with putative...
Physical exercise dramatically increases the energy expenditure of animals. In terms substrate, at onset exercise, contribution carbohydrates to is relatively predominant, and decreases gradually with progression while fat consumption progressively. The ventromedial hypothalamus (VMH) a nucleus in that regulates whole body metabolism via sympathetic nervous system. Some reports have indicated noradrenergic projections VMH are involved during exercise. However, it not clear whether influences...
Boron (B) is a metalloid that essential for plant growth but toxic when present in excess. Arabidopsis BOR1 borate exporter, facilitating B translocation from root to shoot under limited-B conditions. shows stele side polar localization the plasma membrane of various cells, presumably support toward stele. degraded high-B supply through vacuolar sorting via ubiquitination at K590 residue prevent accumulation level shoots. A previous study showed overexpression control cauliflower mosaic...
Abstract Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many these on homeostasis is largely unclear due to a lack detailed functional analyses. Here we report ligand-dependent corepressor-like (LCoRL) as regulator for body weight glucose homeostasis. Although GWAS data show that LCoRL strongly size, homeostasis, other traits livestock, investigations had not been performed. We generated Lcorl...
Cannabinoid 1 receptor (CB1R) inverse agonists reduce body weight and improve several parameters of glucose homeostasis. However, these drugs have also been associated with deleterious side effects. CB1R expression is widespread in the brain peripheral tissues, but whether specific sites can mediate beneficial metabolic effects drugs, while avoiding untoward effects, remains unclear. Evidence suggests may act on key within central nervous system to metabolism. The ventromedial hypothalamus...