A5085330812- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Blood Pressure and Hypertension Studies
- Pain Mechanisms and Treatments
- Thermoregulation and physiological responses
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- Mosquito-borne diseases and control
- Ion Channels and Receptors
- Cardiovascular Syncope and Autonomic Disorders
- Exercise and Physiological Responses
- Cardiovascular Health and Disease Prevention
- Sports Performance and Training
- Transcranial Magnetic Stimulation Studies
- Parathyroid Disorders and Treatments
- Biochemical effects in animals
- Non-Invasive Vital Sign Monitoring
- Bone health and osteoporosis research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stress Responses and Cortisol
- Cardiovascular Effects of Exercise
- Medical Malpractice and Liability Issues
- Vagus Nerve Stimulation Research
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2015-2024
National Council on Family Relations
2019-2021
University of North Texas
1994-2021
John Wiley & Sons (United States)
2019-2021
Moss Landing Marine Laboratories
2021
Bridgeport Hospital
2020
Oakland University
2020
National Institutes of Health Clinical Center
2020
University of Kentucky
2019
Recent government initiatives to deploy health information technology in the USA, coupled with a growing body of scholarly evidence linking online heath and positive health-related behaviors, indicate widespread belief that access technologies can help reduce healthcare inequalities. However, it is less clear whether benefits greater equitably distributed across population groups, particularly those who are underserved. To examine this issue, article employs 2007 Health Information National...
The operative management of large and giant aneurysms is complicated by their typically atheromatous thick walls, frequent intramural thrombosis with calcification, broad-based necks that often incorporate perforating other vital vessels. Not infrequently, it necessary to at least focally arrest the intracranial circulation open or excise these facilitate vascular reconstruction. This maneuver, in patients whose disease processes have destroyed autoregulatory function who inadequate sources...
The Consumer Assessment of Healthcare Providers and Systems (CAHPS®) Clinician Group Adult Visit Survey enables patients to report their experiences with outpatient medical offices.To evaluate the factor structure reliability CAHPS (CG-CAHPS) Survey.Data from 21,318 receiving care in 450 clinical practice sites collected March 2010 December were analyzed CG-CAHPS Database.Individual level multilevel confirmatory analyses used examine survey responses at patient site levels. We also estimated...
Many patients with obstructive sleep apnea (OSA) have spontaneous periods of stable flow limited breathing during without respiratory events or arousals. In addition, OSA is often more severe REM than NREM and stage 2 slow wave (SWS). The physiological mechanisms for these observations are unknown. Thus we aimed to determine whether the activity two upper airway dilator muscles (genioglossus tensor palatini) end-expiratory lung volume (EELV) differ between (1) spontaneously occurring...
IThas beea only within the last feW years that umotor disturbance known as "apraxia " h&s claimed much atten- tion, o1 been fully 'ivestigated, and 'even yet very few well-markel instat669of cendition have described in English literature.In fact; it is 'mainly tlhrough careful summary oftheworkof Continental authors, pub- lished seven ago by Dr.S&A.K.
Abstract Evidence suggests that brain insulin availability acutely modulates arterial baroreflex function. However, little is known about the impact of blocking receptor (IR) signaling on baroreflex. We hypothesized blockade IR in impairs Our hypothesis was tested using open‐loop analysis to evaluate two subsystems baroreflex: carotid sinus pressure (CSP)–sympathetic nerve activity (SNA) relationship (the neural arc) and SNA–arterial (AP) peripheral arc). In anesthetized healthy male rats,...
1. The purpose of this investigation was to determine if activation the exercise pressor reflex in decerebrate rat induced circulatory responses comparable those reported large mammalian species. 2. To activate both mechanically and metabolically sensitive afferent fibres, static hindlimb contractions were by stimulating cut ends L4 L5 spinal ventral roots Sprague-Dawley rats (300-400 g). selectively stimulate receptors, muscles passively stretched. 3. In intact halothane-anaesthetized...
A rodent model for human Lassa fever was developed which uses inbred (strain 13) and outbred (Hartley) guinea pigs. Strain 13 pigs were uniformly susceptible to lethal infection by 2 or more PFU of virus strain Josiah. In contrast, no than 30% the Hartley died regardless dose. lethally infected pigs, peak titers (10(7) 10(8) PFU) occurred in spleen lymph nodes at 8 9 days, salivary glands 11 lung 14 16 days. Virus reached low (10(4) plasma brain intermediate liver, adrenal glands, kidney,...
Background— In heart failure, exercise elicits excessive increases in mean arterial pressure (MAP) and rate (HR). Using a novel rat model, we previously demonstrated that this exaggerated cardiovascular responsiveness is mediated by an overactive pressor reflex (EPR). Although determined abnormalities the group IV afferent neuron population (associated with metabolic component of reflex) initiate development EPR these fibers do not mediate enhanced circulatory responses to exercise....
Several uncontrolled studies of hyperbaric treatment in children with autism have reported clinical improvements; however, this has not been evaluated to date a controlled study. We performed multicenter, randomized, double-blind, trial assess the efficacy autism. 62 recruited from 6 centers, ages 2–7 years (mean 4.92 ± 1.21), were randomly assigned 40 hourly treatments either at 1.3 atmosphere (atm) and 24% oxygen ("treatment group", n = 33) or slightly pressurized room air 1.03 atm 21%...
Following a mild traumatic brain injury (TBI) event, the secondary that persists after initial blow to head consists of excitotoxicity, decreased cerebral glucose levels, oxidant injury, mitochondrial dysfunction, inflammation, and neuronal cell death. To date, there are no effective interventions used at decreasing TBI.In this study, male mice were treated with either placebo or resveratrol (100 mg/kg) 5 minutes 12 hours TBI. The injured using controlled cortical impact device. In...
Small-for-gestational-age infants are known to develop hypertension in adulthood. This prenatal programming of (PPH) can result from several insults including maternal dietary protein deprivation, uteroplacental insufficiency, and administration glucocorticoids. The mechanisms underlying the development remain unclear although sympathetic nervous system has been indirectly implicated. study was designed directly measure renal nerve activity both at rest during physical stress an animal model...
Background— In heart failure, the cardiovascular response to activation of skeletal muscle exercise pressor reflex (EPR) is exaggerated. Group IV afferent neurons, primarily stimulated by metabolic by-products work, contribute significantly EPR. Therefore, it was postulated that alterations in activity group neurons EPR dysfunction manifest failure. Methods and Results— fibers were ablated neonatal Sprague-Dawley rats subcutaneous administration capsaicin. capsaicin-treated adult animals,...
In hypertension, exercise elicits excessive elevations in mean arterial pressure (MAP) and heart rate (HR) increasing the risk for adverse cardiac events stroke during physical activity. The pressor reflex (a neural drive originating skeletal muscle), central command cortical brain centres) tonically active baroreflex contribute importantly to cardiovascular control exercise. Each of these inputs potentially mediates heightened response activity hypertension. However, given that overactivity...
Exercise in hypertensive individuals elicits exaggerated increases mean arterial pressure (MAP) and heart rate (HR) that potentially enhance the risk for adverse cardiac events or stroke. Evidence suggests exercise pressor reflex function (EPR; a originating skeletal muscle) is this disease contributes significantly to potentiated cardiovascular responsiveness. However, mechanism of EPR overactivity hypertension remains unclear. mediated by muscle mechanoreflex (activated stimulation...
In hypertension, the blood pressure response to exercise is exaggerated. We demonstrated previously that this heightened pressor physical activity mediated by an overactive skeletal muscle reflex (EPR), with important contributions from its metaboreflex and mechanoreflex components. However, mechanisms driving abnormal EPR activation are largely unknown. Recent evidence in humans suggests partially mediates enhanced EPR-induced via abnormally large changes sympathetic nerve (SNA). Whether...
The circulatory response to exercise is exaggerated in hypertension potentially increasing the risk for adverse cardiovascular events. Evidence suggests skeletal muscle metaboreflex contributes this abnormal response. However, as sensitivity of reflex has been reported be both reduced and potentiated hypertension, its role remains controversial. In addition, receptor mechanisms underlying dysfunction disease remain undetermined. To address these issues, activity was assessed during...
Background: Inorganic phosphate (Pi) is used extensively as a preservative and flavor enhancer in the Western diet. Physical inactivity, common feature of societies, associated with increased cardiovascular morbidity mortality. It unknown whether dietary Pi excess contributes to exercise intolerance physical inactivity. Methods: To determine an association between activity humans, we assessed relationship serum actigraphy-determined level, well left ventricular function by cardiac magnetic...
Cardiovascular responses to exercise are exaggerated in chronic kidney disease (CKD) patients. Enhanced sympathetic activation is thought play a role with the pressor reflex (EPR), originating contracting muscle, modulating this response. Previous studies suggest an overactive EPR CKD patients as indicated by muscle overactivation during static handgrip exercise. However, of could not be fully elucidated due experimental constraints inherent humans. The purpose study was specifically test...