A5038217155- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Exercise and Physiological Responses
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Thermoregulation and physiological responses
- Adipose Tissue and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Acute Myocardial Infarction Research
- Biochemical effects in animals
- Traditional Chinese Medicine Studies
- Birth, Development, and Health
The University of Texas Southwestern Medical Center
2019-2025
Southwestern Medical Center
2020-2025
Chosun University Hospital
2023-2025
Pinnacle Clinical Research
2025
GTx (United States)
2025
Jaseng Hospital of Korean Medicine
2023
Kyung Hee University
2023
Chonnam National University Hwasun Hospital
2015-2021
Ajou University
2015-2019
University of Florida
2013-2018
The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, conducting different omics data analyses, we demonstrated that induces cell death in a proximal tubular line suppressing glycolysis- and tricarboxylic acid (TCA)/mitochondria-related genes. Furthermore, analysis the urine from cisplatin-treated rats revealed lower expression levels enzymes involved glycolysis, TCA cycle, genes related to mitochondrial stability confirmed cisplatin-related metabolic...
Sarcopenia is associated with metabolic disorders, cardiovascular disease, and mortality; however, its association depression in the general population remains unknown. Therefore, we investigated this Korea.This study included 8,958 8,518 subjects from 2010-2011 Korean National Health Nutrition Examination Survey V-1, 2. The was restricted to participants ≥20 years of age who had completed survey, including whole-body dual-energy X-ray absorptiometry scans. After exclusion, 7,364 were our...
Large elastic arteries stiffen with age, which predisposes older adults to increased risk for cardiovascular disease. Aerobic exercise training is known reduce the disease, but optimal prescription attenuating large arterial stiffening in not known.The purpose of this randomized controlled trial was compare effect all-extremity high-intensity interval (HIIT) and moderate-intensity continuous (MICT) on aortic pulse wave velocity (PWV) carotid artery compliance adults.Forty-nine sedentary (age...
Abstract Evidence suggests that brain insulin availability acutely modulates arterial baroreflex function. However, little is known about the impact of blocking receptor (IR) signaling on baroreflex. We hypothesized blockade IR in impairs Our hypothesis was tested using open‐loop analysis to evaluate two subsystems baroreflex: carotid sinus pressure (CSP)–sympathetic nerve activity (SNA) relationship (the neural arc) and SNA–arterial (AP) peripheral arc). In anesthetized healthy male rats,...
In a previous study, we reported that serpin peptidase inhibitor clade A member 1 (serpinA1) is upregulated in Snail-overexpressing gastric cancer. Although serpinA1 has been studied several types of cancer, little known about its roles and mechanisms action. this examined the role migration invasion cancers determined underlying mechanism. Expression levels were assessed by western blot analyses real-time PCR. Snail binding to promoter was analysed chromatin immunoprecipitation (ChIP)...
Background: Inorganic phosphate (Pi) is used extensively as a preservative and flavor enhancer in the Western diet. Physical inactivity, common feature of societies, associated with increased cardiovascular morbidity mortality. It unknown whether dietary Pi excess contributes to exercise intolerance physical inactivity. Methods: To determine an association between activity humans, we assessed relationship serum actigraphy-determined level, well left ventricular function by cardiac magnetic...
Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to identify central precocious puberty (CPP). This requires multiple blood samples at different time points measure gonadotropin levels, and therefore expensive, time-consuming, uncomfortable for patients. We aimed simplify GnRH require fewer samples.A study of 166 girls with was undertaken. Blood were obtained 0, 15, 30, 45, 60, 90, 120 min after administration, levels luteinizing (LH) follicle-stimulating (FSH)...
Obesity increases linearly with age and is associated impaired vascular endothelial function increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to in disease; however, their role uncomplicated human obesity unknown. Because plasma aldosterone levels are elevated adipocytes may be a source aldosterone, we hypothesized that modulate older adults an adiposity-dependent manner. To test this hypothesis, administered MR blockade (eplerenone; 100 mg/day) for 1...
Abstract Mechanical distortion of working skeletal muscle induces sympathoexcitation via thin fibre afferents, a reflex response known as the mechanoreflex. However, to date, receptor ion channels responsible for mechanotransduction in remain largely undetermined. Transient potential vanilloid 4 (TRPV4) is sense mechanical stimuli such shear stress or osmotic pressure various organs. It hypothesized that TRPV4 thin‐fibre primary afferents innervating involved mechanotransduction....
Abstract Background Fractional flow reserve (FFR) or angiography-guided complete revascularization is not evaluated in acute myocardial infarction (AMI) patients with multivessel disease and reduced left ventricular ejection fraction (LVEF). Objectives To evaluate impact of FFR-guided percutaneous coronary intervention (PCI) for AMI according to systolic function. Methods We performed a pre-specified analysis the FRAME-AMI trial, which randomly allocated 562 undergo either PCI (FFR≤0.80)...
The cardiovascular responses to exercise are potentiated in patients with type 2 diabetes mellitus (T2DM). However, the underlying mechanisms causing this abnormality remain unknown. Central command (CC) and pressor reflex (EPR) known contribute significantly control during exercise. Thus these neural signals viable candidates for generation of abnormal circulatory regulation disease. We hypothesized that augmentations CC as well EPR function heightened T2DM. To test hypothesis, changes mean...
SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type diabetes. Mechanisms underlying this action are unknown but SGLT2i-induced sympathoinhibition thought play role. Whether reduces BP and sympathetic nerve activity (SNA) nondiabetic prehypertension model unknown.Accordingly, we assessed changes conscious using radiotelemetry alterations mean arterial renal SNA during simulated...
Cardiovascular responses to exercise are exaggerated in chronic kidney disease (CKD) patients. Enhanced sympathetic activation is thought play a role with the pressor reflex (EPR), originating contracting muscle, modulating this response. Previous studies suggest an overactive EPR CKD patients as indicated by muscle overactivation during static handgrip exercise. However, of could not be fully elucidated due experimental constraints inherent humans. The purpose study was specifically test...
We have previously reported that insulin potentiates the response to mechanical stimuli in small dorsal root ganglion (DRG) neurons. However, mechanisms underlying insulin-induced potentiated responsiveness stimulation sensory neurons remain unclear. Transient receptor potential vanilloid 4 (TRPV4) is expressed as a mechanosensitive channel DRG and activated by stimuli. therefore hypothesized augments enhancing sensitization of TRPV4 channels. Co-localization TRPV4, (IR) C-fiber marker...
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Transcription factors (TFs) are gene expression regulators that bind to DNA in a sequence-specific manner and determine the functional characteristics of gene. It is worthwhile study unique such specific TF-binding pattern DNA. Sox2 recognizes 6- 7-base pair consensus sequence; central four bases binding site highly conserved, whereas two three flanking variable. Here, we attempted analyze affinity specificity protein for distinct sequence patterns via steered molecular dynamics, which...
Key points Insulin is known to activate the sympathetic nervous system centrally. A mechanical stimulus tissues activates via thin fibre afferents. Evidence suggests that insulin modulates putative mechanosensitive channels in dorsal root ganglion neurons of these In present study, we report novel finding augments responsiveness afferents not only at ganglion, but also muscle tissue levels. Our data suggest sympathoexcitation mediated insulin‐induced sensitization peripherally. The study...
The exercise pressor reflex (EPR) is exaggerated in type 2 diabetes mellitus (T2DM), but the underlying central nervous system aberrations have not been fully delineated. Stimulation of muscle afferents within working skeletal activates EPR, by sending information to neurons brainstem, where it integrated and results reflexively increased mean arterial pressure (MAP) sympathetic nerve activity. Brain insulin known regulate neural activity brainstem. We hypothesize that brain injection T2DM...
The blood pressure response to exercise is exaggerated in the type 1 diabetes mellitus (T1DM). An overactive pressor reflex (EPR) contributes potentiated response. However, mechanism(s) underlying this abnormal EPR activity remains unclear. This study tested hypothesis that heightened T1DM mediated by EPR-induced sympathetic overactivity. Additionally, examined whether single muscle afferents are sensitized PKC (protein kinase C) activation disease. Sprague-Dawley rats were intraperitoneally...