A5004207202- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- Genetic Neurodegenerative Diseases
- Hemoglobin structure and function
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Endoplasmic Reticulum Stress and Disease
- Heart Failure Treatment and Management
- Polyomavirus and related diseases
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cancer Immunotherapy and Biomarkers
The University of Texas Southwestern Medical Center
2015-2024
Southwestern University
2023
Southwestern Medical Center
2007-2022
Center for Neuroscience and Regenerative Medicine
2022
University of Kentucky
2019
Mayo Clinic in Florida
2014
Infinity Vision Dallas
2013
Duke Medical Center
2013
Cardiovascular Research Center
2013
Brigham and Women's Hospital
2009
We recently identified a brief time period during postnatal development when the mammalian heart retains significant regenerative potential after amputation of ventricular apex. However, one major unresolved question is whether neonatal mouse can also regenerate in response to myocardial ischemia, most common antecedent failure humans. Here, we induced ischemic infarction (MI) 1-d-old mice and found that this results extensive necrosis systolic dysfunction. Remarkably, mounted robust...
Genome editing with CRISPR/Cas9 is a promising new approach for correcting or mitigating disease-causing mutations. Duchenne muscular dystrophy (DMD) associated lethal degeneration of cardiac and skeletal muscle caused by more than 3000 different mutations in the X-linked dystrophin gene (
A mouse model with a common human DMD mutation was created and corrected by CRISPR-Cas9 gene editing.
Self-complementary AAV-packaged CRISPR-Cas9 genome editing components rescue Duchenne muscular dystrophy.
HomeCirculationVol. 144, No. 6In-Depth Evaluation of a Case Presumed Myocarditis After the Second Dose COVID-19 mRNA Vaccine Free AccessCase ReportPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree ReportPDF/EPUBIn-Depth Alagarraju Muthukumar, Madhusudhanan Narasimhan, Quan-Zhen Li, Lenin Mahimainathan, Imran Hitto, Franklin...
Signaling events controlled by calcineurin promote cardiac hypertrophy, but the degree to which such pathways are required transduce effects of various hypertrophic stimuli remains uncertain. In particular, administration immunosuppressive drugs that inhibit has inconsistent in blocking hypertrophy animal models. As an alternative approach inhibiting hearts intact animals, transgenic mice were engineered overexpress a human cDNA encoding calcineurin-binding protein, myocyte-enriched...
This study sought to examine the frequency and hemodynamic correlates of shortness breath when bending forward, a symptom we have termed "bendopnea."Many heart failure patients describe bendopnea such as putting on their shoes. has not previously been characterized.We conducted prospective 102 subjects with systolic referred for right-heart catheterization. Time onset was measured prior Forty-six also underwent assessment sitting bending. Hemodynamic profiles were assigned basis whether...
Although right atrial pressure (RAP) and pulmonary capillary wedge (PCWP) are correlated in heart failure, a sizeable minority of patients, the RAP PCWP not tightly coupled. The basis this variability RAP/PCWP ratio, whether it conveys prognostic value, is known.We analyzed Evaluation Study Congestive Heart Failure Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial database. Baseline characteristics, including echocardiographic assessment ventricular (RV) structure function,...
Background —Harmonic power Doppler imaging (HPDI) is a novel technique for assessing myocardial perfusion by contrast echocardiography in humans. The purpose of this study was to compare HPDI with that obtained 99m Tc-sestamibi single photon emission computed tomography (SPECT) during rest and pharmacological stress. Methods Results —HPDI performed on 123 patients who were referred SPECT known or suspected coronary artery disease. Images at baseline adenosine infusion (0.14 mg · kg − 1 min...
Hemoproteins are widely distributed among unicellular eukaryotes, plants, and animals. In addition to myoglobin hemoglobin, a third hemoprotein, neuroglobin, has recently been isolated from vertebrate brain. Although the functional role of this novel member globin family remains unclear, neuroglobin contains heme-binding domain may participate in diverse processes such as oxygen transport, storage, nitric oxide detoxification, or modulation terminal oxidase activity. study we utilized situ...
Cystatin C, a novel marker of renal function, has been associated with heart failure and cardiovascular mortality in older individuals. We tested the hypothesis that cystatin C is preclinical cardiac structural functional abnormalities younger population-based sample.The study included participants Dallas Heart Study (ages 30 to 65 years) who had measurements MRI. The associations left ventricular (LV) mass, LV end-systolic -diastolic volumes, concentricity (LV mass/LV end-diastolic volume),...
Myoglobin is an oxygen storage molecule that selectively expressed in cardiac and slow-twitch skeletal muscles have a high demand. Numerous studies implicated hypoxia the regulation of myoglobin expression as adaptive response to hypoxic stress. However, details this relationship remain undefined. In present study, adult mice exposed 10% for periods up 3 wk exhibited increased only working heart, whereas was either diminished or unchanged muscle groups. vitro vivo revealed presence absence...
Background Biomarkers for early detection of anthracycline (AC)‐induced cardiotoxicity may allow cardioprotective intervention before irreversible damage. Circulating micro RNA s (mi RNAs ) are promising biomarkers cardiovascular disease, however, have not been studied in the setting AC‐induced cardiotoxicity. This study aimed to identify alterations plasma mi expression children and correlate with markers cardiac injury. Methods Results Candidate profiling 24 was performed 33 after a cycle...
Duchenne muscular dystrophy (DMD) is frequently complicated by development of a cardiomyopathy. Despite significant medical advances provided to DMD patients over the past 2 decades, there remains group who die prematurely. The current study sought identify set prognostic factors that portend worse outcome among adult patients.A retrospective cohort 43 consecutive was followed in UT Southwestern Neuromuscular Cardiomyopathy Clinic. Clinical data were abstracted from electronic record...
Background— In heart failure, the cardiovascular response to activation of skeletal muscle exercise pressor reflex (EPR) is exaggerated. Group IV afferent neurons, primarily stimulated by metabolic by-products work, contribute significantly EPR. Therefore, it was postulated that alterations in activity group neurons EPR dysfunction manifest failure. Methods and Results— fibers were ablated neonatal Sprague-Dawley rats subcutaneous administration capsaicin. capsaicin-treated adult animals,...
Significance Mammalian skeletal muscle is a dynamic and plastic tissue, capable of responding to physiological demands pathophysiological stresses. This response relies on the muscle’s ability activate myogenic progenitor cells (MPCs) resulting in myogenesis. In this study, we demonstrate that cytoglobin, stress-responsive hemoprotein abundantly expressed MPCs, modulating MPCs’ viability proliferative/differentiative capacity. Collectively, our data cytoglobin serves an important role...
Background— A noninvasive biomarker that could accurately diagnose acute rejection (AR) in heart transplant recipients obviate the need for surveillance endomyocardial biopsies. We assessed performance metrics of a novel high-sensitivity cardiac troponin I (cTnI) assay this purpose. Methods and Results— Stored serum samples were retrospectively matched to biopsies 98 recipients, who survived ≥3 months after transplant. AR was defined as International Society Heart Lung Transplantation grade...
Purpose: The most common cause of Fuchs' endothelial corneal dystrophy (FECD) is an intronic CTG repeat expansion in TCF4. Expanded CUG RNA colocalize with splicing factor, muscleblind-like 1 (MBNL1), nuclear foci endothelium as a molecular hallmark. Myotonic type (DM1) neuromuscular disorder caused by the 3′-untranslated region (UTR) DMPK. In this study, we examine for RNA-MBNL1 cells FECD subjects DM1, test hypothesis that DM1 patients are at risk FECD, and determine prevalence TCF4 DMPK...