A5103251286- Probiotics and Fermented Foods
- Connexins and lens biology
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Heat shock proteins research
- Meat and Animal Product Quality
- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- Fermentation and Sensory Analysis
- Mitochondrial Function and Pathology
- Heart Failure Treatment and Management
- Food Quality and Safety Studies
- Genetic factors in colorectal cancer
- Microbial Metabolites in Food Biotechnology
- Gut microbiota and health
- Yersinia bacterium, plague, ectoparasites research
- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced cardiotoxicity and mitigation
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Enzyme Production and Characterization
- Polyamine Metabolism and Applications
- Pancreatic function and diabetes
- Milk Quality and Mastitis in Dairy Cows
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
Nankai University
2025
Ministry of Agriculture and Rural Affairs
2020-2024
Inner Mongolia Agricultural University
2014-2024
Daping Hospital
2024
Army Medical University
2024
The University of Texas Southwestern Medical Center
2017-2024
Guangdong Institute of New Materials
2024
Southwestern Medical Center
2023
Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies. We recently demonstrated in mice that combination of metabolic and hypertensive stress recapitulates key features human HFpEF. Objective: Using this novel preclinical HFpEF model, we set out to define manipulate dysregulations occurring myocardium. Methods Results: observed impairment mitochondrial fatty acid oxidation associated hyperacetylation enzymes the pathway....
Oculodentodigital dysplasia (ODDD) is an autosomal dominant disorder characterized by pleiotropic developmental anomalies of the limbs, teeth, face and eyes that was shown recently to be caused mutations in gap junction protein alpha 1 gene (GJA1), encoding connexin 43 (Cx43). In course performing N-ethyl-N-nitrosourea mutagenesis screen, we identified a mouse mutation exhibits many classic symptoms ODDD, including syndactyly, enamel hypoplasia, craniofacial cardiac dysfunction. Positional...
Previously, we demonstrated that the flavor of milk fermented with Lactobacillus delbrueckii subsp. bulgaricus (IMAU20401) and Streptococcus thermophilus (IMAU40133) at a 1:1000 ratio was superior to other ratios two strains. In this study, plantarum P-8 used as probiotic bacterium. Six (1:1, 1:5, 1:10, 1:50, 1:100, 1:1000) L. yogurt starter were evaluated. A total 66 volatile compounds including aldehydes, ketones, acids, alcohols, esters, aromatic identified in six different 0 d storage....
Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus are key factors in the fermentation process final quality of dairy products worldwide. This study was performed to investigate effects proportions isolated from traditionally fermented China Mongolia on profile volatile compounds produced samples. Six proportional combinations (1:1, 1:10, 1:50, 1:100, 1:1000, 1:10,000) L. IMAU20401 S. ND03 were considered, volatiles identified quantified by solid-phase microextraction...
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart and one for which no efficacious therapies exist. Obesity lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations perturbations in homeostasis HFpEF are largely unknown. Here, we report that cardiomyocyte steatosis coupled increases activity transcription factor FoxO1 (Forkhead box protein O1). depletion, as well over-expression Xbp1s (spliced...
Lactic acid bacteria (LAB) are industrially important that widely used in the fermented food industry, especially manufacture of yogurt. The fermentation characteristics LAB an factor affecting physicochemical properties yogurts. Here, different ratios L. delbrueckii subsp. bulgaricus IMAU20312 and S. thermophilus IMAU80809 were compared with a commercial starter JD (control) for their effects on viable cell counts, pH values, titratable acidity (TA), viscosity water holding capacity (WHC)...
Acrolein (Acr), a ubiquitous environmental contaminant, is human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N2-cyclic propano-2′-deoxyguanosine adducts (α-OH-Acr-dG γ-OH-Acr-dG). We demonstrate here that Acr-dG be efficiently repaired by the nucleotide excision repair (NER) pathway in normal bronchial epithelia (NHBE) lung fibroblasts (NHLF). However, same were poorly processed cell lysates isolated from Acr-treated NHBE NHLF, suggesting inhibits NER. In...
Lactobacillus delbrueckii subsp. bulgaricus is one of the predominant lactic acid bacterial species used as starter cultures in industrial fermented dairy manufacturing, it strongly affects quality products. Volatile flavor compound profiles and fermentation characteristics are considered to be most important indicators for culture screening. In present study, volatile compounds milk by 17 test strains L. a commercial strain control were identified using solid-phase microextraction (SPME)...
Gap junctional coupling among cumulus cells is important for oogenesis since its deficiency in mice leads to impaired folliculogenesis. Multiple connexins (Cx), the subunits of gap junction channels, have been found within ovarian follicles several species but little known about human follicles. The aim this study was determine which contribute junctions and explore possible relationship between connexin expression pregnancy outcome from vitro fertilization (IVF). Cumulus were obtained IVF...
The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 proximity to the Down syndrome critical region. hearts and brains Rcan1 KO mice are more susceptible damage from ischemia/reperfusion (I/R); however, underlying cause not known.Mitochondria key mediators I/R damage. goal these studies was determine impact mitochondrial dynamics function.Using both neonatal...
The lactic acid bacterium Streptococcus thermophilus is a major starter culture for the production of dairy products. In this study, physiochemical characteristics milk fermented by MGA45-4 isolate S. were analyzed. Our data indicate that using maintained high viable cell count (8.86 log10 colony-forming units/mL), and relatively pH (4.4), viscosity (834.33 mPa·s), water holding capacity (40.85%) during 14 days storage. By analyzing volatile compound profile solid-phase microextraction gas...
Exopolysaccharides (EPSs), which are produced by lactic acid bacteria, have been found to improve the texture and functionality of fermented dairy products. In a previous study, four nitrogen sources were identified as affecting yield, molecular weight structure EPSs Streptococcus thermophilus IMAU20561 in M17 medium. this genomic transcriptomics novel eps gene cluster responsible for assembly repeating units EPS is reported. This (22.3 kb), consisting 24 open reading frames, located...
In vitro and in vivo analyses were conducted to examine the correlations between production, expression, secretion of VEGF-C/D-VEGFR-3/NRP-2 axis various levels lymphatic metastatic potential murine hepatocellular carcinoma cells. Quantitative real-time PCR, western blotting, cytoimmunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay employed assess expression at gene, protein, cytological, histological levels. both experiments, ligands VEGF-C/D receptors VEGFR-3/NRP-2...
Streptococcus thermophilus (S. thermophilus) is a species widely used in the dairy industry to accelerate acidification rate and improve texture flavour characteristics of products. However, most S. have galactose-negative (Gal-) phenotypes, which can lead accumulation free galactose fermented In previous study, mutant IMAU20551Y was obtained by N-methyl-N'-nitro-N-nitrosoguanidine (NTG) mutagenesis key enzymes related metabolism were significantly changed compared with wild type....
Connexin43 (Cx43, encoded by Gja1) is required for ovarian follicle development in the mouse. It strongly expressed granulosa cells, which it forms intercellular gap junction channels that couple cells metabolically. However, recent evidence indicates undocked hemichannels can also have physiological roles such as mediating release of small messenger molecules, including ATP. In this study, presence Cx43 was revealed dye uptake induced either mechanical stimulation or reduction extracellular...
Bone development and modeling requires precise gap junctional intercellular communication (GJIC). Oculodentodigital dysplasia (ODDD) is an autosomal dominant human disease caused by mutations in the gene (GJA1) encoding junction protein, connexin43 (Cx43). The characterized craniofacial bone deformities limb abnormalities. It our hypothesis that Cx43 mutation causes osteoblast dysfunction, which may contribute to phenotype of ODDD.We expressed mouse ODDD-linked mutants MC3T3-E1 cells primary...