A5082516218- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Plant biochemistry and biosynthesis
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Effects of Natural Compounds
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Chromatography in Natural Products
- Bioactive natural compounds
- Chemical synthesis and alkaloids
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Bioactive Natural Diterpenoids Research
- Crystallography and molecular interactions
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Biological Activity of Diterpenoids and Biflavonoids
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
China Pharmaceutical University
2016-2025
Tianjin First Center Hospital
2017-2025
Tianjin Medical University
2017-2025
Nankai University
2023-2025
Jiangsu Provincial Academy of Traditional Chinese Medicine
2015-2021
Zero to Three
2019
University of Minnesota
2012-2018
Tianjin Central Hospital of Gynecology Obstetrics
2018
University of Illinois Chicago
2014-2017
Donghua University
2013-2015
Surface fuctionalization plays a crucial role in developing efficient nanoparticulate drug-delivery systems by improving their therapeutic efficacy and minimizing adverse effects. Here we propose simple layer-by-layer self-assembly technique capable of constructing mesoporous silica nanoparticles (MSNs) into pH-responsive drug delivery system with enhanced biocompatibility. In this system, biocompatible polyelectrolyte multilayers alginate/chitosan were assembled on MSN's surface to achieve...
High levels of urinary lactate are an increased risk progression in patients with diabetic kidney disease (DKD). However, it is still unveiled how drive DKD. Epithelial-mesenchymal transition (EMT), which characterized by the loss epithelial cells polarity and cell-cell adhesion, acquisition mesenchymal-like phenotypes, widely recognized a critical contributor to Here, we found switch from oxidative phosphorylation (OXPHOS) toward glycolysis AGEs-induced renal tubular cells, thus leading...
A drug-loaded implantable scaffold is a promising alternative for the treatment of tissue defect after tumor resection. In this study, mesoporous silica nanoparticles (MSNs) were used as carriers to load an anticancer drug - doxorubicin hydrochloride (DOX), and DOX-loaded MSNs (DOX@MSNs) subsequently incorporated into poly(l-lactic acid) (PLLA) nanofibers via electrospinning, resulting in new nanofibrous (PLLA/DOX@MSNs). The as-prepared composite was characterized by various techniques....
Cyclocarya paliurus has been used commonly to treat diabetes in China. However, the effective components and effect of plant origin remain unclear. In this study, C. leaves with different chemical compositions were selected from five geographical locations, their effects on streptozotocin (STZ)-induced diabetic mice evaluated both ethanol aqueous extracts. Glucose levels, lipid biomarkers liver kidney function measured. The principal extracts locations differed quantitatively qualitatively....
DNA ligases play essential roles in replication and repair. Bacteriophage T4 ligase is the first ATP-dependent enzyme to be discovered widely used molecular biology, but its structure remained unknown. Our crystal of bound shows a compact α-helical DNA-binding domain (DBD), nucleotidyl-transferase (NTase) domain, OB-fold which together fully encircle DNA. The DBD exhibits remarkable structural homology core helices larger DBDs from eukaryotic archaeal ligases, it lacks additional components...
Cell adhesion, migration and invasion are critical steps for carcinogenesis cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation anti-metastasis properties. Herein, GAEE, G. lucidum extract mainly contains ganoderiol A (GA), dihydrogenated GA isomer, was shown to inhibit the abilities of adhesion migration, while have slight influence on that highly metastatic breast MDA-MB-231 cells at...
Cyclocarya paliurus is an edible and medicinal plant containing various bioactive components with significant health benefits. A combinative method using high-performance liquid chromatography (HPLC) fingerprint quantitative analysis was developed successfully applied for characterization quality evaluation of C. leaves collected from 18 geographical locations China. For the analysis, 21 common peaks were observed among samples, these identified by coupled quadrupole time-of-flight mass...
AA could decrease TGF-β1 secretion and suppress tubulointerstitial fibrosis by directly inhibiting TGF-βR1 activate the autophagy–lysosome system in DN fibrosis.
In vitro and in vivo analyses were conducted to examine the correlations between production, expression, secretion of VEGF-C/D-VEGFR-3/NRP-2 axis various levels lymphatic metastatic potential murine hepatocellular carcinoma cells. Quantitative real-time PCR, western blotting, cytoimmunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay employed assess expression at gene, protein, cytological, histological levels. both experiments, ligands VEGF-C/D receptors VEGFR-3/NRP-2...
Cyclocarya paliurus (Batal) Iljinskaja (Juglandaceae) is an edible and medicinal plant; the leaves are used in Chinese folkloric medicine to treat dyslipidaemia diabetes.This study evaluates antihyperlipidaemic potential of triterpenic acid-enriched fraction (TAE) from C. underlying mechanism.The hyperlipidaemic rats were induced by high fat diet for 6 weeks. After oral administration TAE (200 400 mg/kg), neutral (150 300 mg/kg) statin (4 4 weeks, lipid profile apolipoprotein (apoB48) level...
This paper presents a facile method for the fabrication of uniform hollow mesoporous silica nanoparticles (HMSNs) with tunable shell thickness and pore size. In this method, series amphiphilic block copolymers polystyrene-b-poly (acrylic acid) (PS-b-PAA) different hydrophobic (PS) lengths were first synthesized via atom transfer radical polymerization (ATRP). The as-synthesized PS-b-PAA cetyltrimethylammonium bromide (CTAB) subsequently used as co-templates to fabricate HMSNs. approach...