A5064099494- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Plant Virus Research Studies
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Organic Electronics and Photovoltaics
- Cytomegalovirus and herpesvirus research
- Enzyme Structure and Function
- Animal Virus Infections Studies
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- HIV/AIDS drug development and treatment
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Conducting polymers and applications
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Multiple Myeloma Research and Treatments
University of Minnesota
2016-2025
Beijing University of Technology
2019-2024
Beijing Normal University
2024
Jinan University
2024
Xi'an Polytechnic University
2022-2023
Biotechnology Institute
2023
Tencent (China)
2023
University of Minnesota Medical Center
2017-2022
Masonic Cancer Center
2015-2022
University of Minnesota System
2022
A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-191,2. key to tackling this pandemic understand the receptor recognition mechanism of virus, which regulates its infectivity, pathogenesis host range. SARS-CoV-2 SARS-CoV recognize same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans3,4. Here we determined crystal structure receptor-binding domain (RBD) spike protein (engineered...
Abstract Conjugated polymers with high thermoelectric performance enable the fabrication of low‐cost, large‐area, low‐toxicity, and highly flexible devices. However, compared to their p‐type counterparts, n‐type polymer materials show much lower performance, which is largely due inefficient doping a conductivity. Herein, it reported that development donor–acceptor (D–A) enhanced n‐doping efficiency through donor engineering backbone. Both electrical conductivity 1.30 S cm −1 an excellent...
High-fidelity replication of the large RNA genome coronaviruses (CoVs) is mediated by a 3'-to-5' exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises nucleotides including antiviral drugs misincorporated low-fidelity viral RNA-dependent polymerase (RdRp) and has also been implicated recombination resistance to innate immunity. Here, we determined 1.6-Å resolution crystal structure severe acute respiratory syndrome CoV 2 (SARS-CoV-2) ExoN complex with its essential...
A novel n-type small molecule FFI-1 was synthesized as the electron acceptor to replace PCBM in solution-processed organic BHJ solar cells. Its LUMO level (around -3.5 eV) both matches work function of cathode and increases VOC devices, making it a promising candidate. With P3HT: (1:2 w/w) active layer LiF/Al cathode, best power conversion efficiency (PCE) reaches 1.86%. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not...
ABSTRACT Beta toxin is a neutral sphingomyelinase secreted by certain strains of Staphylococcus aureus . This virulence factor lyses erythrocytes in order to evade the host immune system as well scavenge nutrients. The structure beta was determined at 2.4-Å resolution using crystals that were merohedrally twinned. similar sphingomyelinases Listeria ivanovii and Bacillus cereus belongs DNase I folding superfamily; addition sphingomyelinases, proteins most structurally related include human...
A corannulene-based derivative was facilely developed with a bowl-shaped structure. Highly ordered cofacial convex–concave stacking realized through tuning the molecular dipoles, which is favorable for charge transport. Organic field-effect transistors were fabricated, providing opportunities broad class of corannulene derivatives and buckybowl aromatics application in future organic electronic devices.
Despite the scarcity of SARS-CoV-2 receptor—human angiotensin-converting enzyme 2 (ACE2)—in respiratory tract, omicron variant efficiently infects causing rapid and widespread infections COVID-19. The contains extensive mutations in receptor-binding domain (RBD) its spike protein that recognizes human ACE2.
How to accurately detect and efficiently sweep Cr(VI) from contaminated water has come into focus. Zirconium-based metal-organic frameworks (MOFs) play vital roles in environmental chemistry due excellent hydrolysis-resistant stability. However, as photochemical probes photocatalysts, poor performances detection sensitivity, selectivity, photosensitiveness limit sole Zr-MOFs' applications. So, it is urgent quest valid strategies break through the dilemmas. Embedding luminous dyes MOFs been...
The sudden emergence and rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant has raised questions about its animal reservoir. Here, we investigated receptor recognition omicron's receptor-binding domain (RBD), focusing on four mutations (Q493R, Q498R, N501Y, Y505H) surrounding two mutational hotspots. These have variable effects RBD's affinity for human angiotensin-converting enzyme (ACE2), but they all enhance mouse ACE2. We further determined...
Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding the molecular mechanisms peptide-mediated cell-cell has been limited a dearth published information about structures components. Here, we present structure PrgX, DNA- peptide-binding protein that regulates conjugative transfer genes Enterococcus faecalis plasmid pCF10 in response...
The detailed relationship between film morphology and the performance of solution processed n-type organic thermoelectric (TE) devices is investigated. It interesting to find that better ordered molecular packing polymer can be achieved by adding a small fraction dopant molecules, which not observed before. structure will favorable for charge carrier mobility. Meanwhile, molecules improve free concentration via doping reaction. As result, significantly enhanced electrical conductivity (12 S...
The flagellum and the injectisome enable bacterial locomotion pathogenesis, respectively. These nanomachines assemble function using a type III secretion system (T3SS). Exported proteins are delivered to export apparatus by dedicated cytoplasmic chaperones for their transport through membrane. structural mechanistic basis of this process is poorly understood. Here we report structures two ternary complexes among flagellar (FliT FliS), protein substrates (the filament-capping FliD flagellin...
For the first time, electron-rich thiophene units were fused into skeleton of corannulene to extend π-surfaces and tune arrangement in single crystals. Two isomeric butterfly-like thiophene-fused dibenzo[a,g]corannulenes (3 5) synthesized. Isomer 3 showed p-type transport properties, with a hole mobility 0.06 cm(2) V(-1) s(-1).
Coronaviruses cause widespread respiratory, gastrointestinal, and central nervous system diseases in humans other animals, threatening human health causing economic loss. Coronavirus nsp9, a member of the replication complex, is an important RNA binding subunit RNA-synthesizing machinery all coronaviruses. However, mechanisms dimerization nucleic acid nsp9 remain elusive. In this study we determined crystal structures PDCoV PEDV. We first found that N-finger from plays critical role...
DNA ligases play essential roles in replication and repair. Bacteriophage T4 ligase is the first ATP-dependent enzyme to be discovered widely used molecular biology, but its structure remained unknown. Our crystal of bound shows a compact α-helical DNA-binding domain (DBD), nucleotidyl-transferase (NTase) domain, OB-fold which together fully encircle DNA. The DBD exhibits remarkable structural homology core helices larger DBDs from eukaryotic archaeal ligases, it lacks additional components...
Abstract Ultralong room temperature phosphorescence (URTP) is an attractive phenomenon in organic photonics. Polymer‐based URTP materials are superior alternatives to traditional inorganic or organometallic phosphors because of their unique transparency and flexibility. However, few polymer films achieve lifetimes longer than 2 s the with show extremely low quantum yields (<2%). Herein, a reasonable strategy proposed simultaneously ultralong high films, based on effective suppression...
Dendrimers are well-defined, highly branched macromolecules that have been widely applied in the fields of catalysis, sensing, and biomedicine. Here, we present a novel multifunctional photochromic dendrimer fabricated through grafting azobenzene units onto dendrimers, which not only enables controlled switching adhesives effective repair coating scratches but also realizes high-performance solar energy storage on-demand heat release. The switchable healable coatings azobenzene-containing...