A5101956479- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Plant biochemistry and biosynthesis
- Extracellular vesicles in disease
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Studies
- Pediatric health and respiratory diseases
- Catalytic C–H Functionalization Methods
- Autophagy in Disease and Therapy
- Pharmacogenetics and Drug Metabolism
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
- Plant Molecular Biology Research
- Natural Antidiabetic Agents Studies
- Catalytic Cross-Coupling Reactions
- Chronic Kidney Disease and Diabetes
- Reproductive System and Pregnancy
- Diet and metabolism studies
- Renal Diseases and Glomerulopathies
- Heat shock proteins research
- RNA Research and Splicing
- Physical Activity and Health
- Berberine and alkaloids research
- Lipid metabolism and disorders
Hangzhou Normal University
2021-2025
Northwest A&F University
2023-2025
East China University of Science and Technology
2024
National Yang Ming Chiao Tung University
2024
Jiangsu Normal University
2023
Chinese Institute for Brain Research
2023
Capital Medical University
2014-2023
Kaohsiung Medical University
2023
Beijing Children’s Hospital
2023
Qilu Hospital of Shandong University
2018-2022
Oxidative stress aggravates mitochondrial injuries and accelerates the proliferation of vascular smooth muscle cells (VSMCs), which are important mechanisms contributing to remodeling in hypertension. We put forward hypothesis that Astaxanthin (ATX), known possess strong features antioxidant, could attenuate by inhibiting VSMC improving function. The potential effects ATX were tested on spontaneously hypertensive rats (SHRs) cultured VSMCs injured angiotensin II (Ang II). results showed...
Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in damage diabetic nephropathy (DN). However, underlying mechanisms remain largely unknown. Here, we investigated role tumor necrosis factor alpha-induced protein 8-like 1 (TNFAIP8L1/TIPE1) high glucose (HG)-induced dysfunction RTECs DN progression. TIPE1 expression was predominantly upregulated patients with mice...
Abstract The metabolism of cancer cells is highly plastic. Cancer can change their preference for nutrient uptake under stress. Fructose one the most common carbohydrates in diet and its also involved development progression tumors. GLUT5, encoded by SLC2A5 , specific fructose transporter mammalian cells. In this study, we found that significantly upregulated lung adenocarcinoma (LUAD) patients overexpression correlated with poor prognosis LUAD patients. expression determined utilization...
Chronic infection with liver flukes (such as Clonorchis sinensis) can induce severe biliary injuries, which cause cholangitis, fibrosis, and even cholangiocarcinoma. The release of extracellular vesicles by C. sinensis (CsEVs) is importance in the long-distance communication between hosts worms. However, biological effects EVs from fluke on injuries underlying molecular mechanisms remain poorly characterized. In present study, we found that CsEVs induced M1-like activation. addition, mice...
Cyclocarya paliurus is an edible and medicinal plant containing various bioactive components with significant health benefits. A combinative method using high-performance liquid chromatography (HPLC) fingerprint quantitative analysis was developed successfully applied for characterization quality evaluation of C. leaves collected from 18 geographical locations China. For the analysis, 21 common peaks were observed among samples, these identified by coupled quadrupole time-of-flight mass...
Non-Saccharomyces yeasts have the potential to ameliorate wine ethanol levels, but such fit-for-purpose yeast strains are still lacking. Seventy-one indigenous non-Saccharomyces isolated from spontaneous fermentations of four regions in China (Ningxia, Xinjiang, Gansu, and Shaanxi) were screened for formation characterized major metabolite profiles synthetic grape juice fermentation obtain with low yields. Four Hanseniaspora less volatile acidity production primarily selected, their yield...
The effects and mechanisms of melatonin on Alzheimer's disease (AD) are still not researched thoroughly. 20E2 cells (HEK293-APPswe cells) a cellular model AD. modulation the structure function mitochondria in need to be studied.The cell was assessed for viability, expression levels mitochondrial biogenesis factors (peroxisome proliferator-activated receptor gamma coactivator 1-alpha [PGC-1α], nuclear respiratory factor 1 [NRF1], 2 [NRF2], transcription A [TFAM]), membrane potential,...
The diagnosis of sebaceous carcinoma presents an important challenge to both clinicians and pathologists, as many cases are initially misdiagnosed clinically histopathologically, potentially leading adverse medical legal outcomes. distinction from benign proliferations other tumors is therefore utmost importance, immunohistochemistry may be useful in this differential. We studied the expression D2-40 (podoplanin) by determine if it can aid differential evaluate possibility lymphangiogenesis...
The aim of the study was to establish an effective prognostic nomogram for esophageal squamous cell carcinoma after radical esophagectomy followed by adjuvant chemotherapy in those previously untreated patients. clinicopathological data from 328 patients who underwent or not at Tianjin Medical University Cancer Institute and Hospital between 2006 2010 were retrospectively studied. Nomograms which predicted survival established based on Cox proportional hazards regression model. To determine...
The prevalence of chronic kidney disease (CKD) varies by race because genetic and environmental factors. Glu504Lys polymorphism in aldehyde dehydrogenase 2 (ALDH2), commonly observed among East Asian people, alters the enzyme's function detoxifying alcohol-derived aldehydes, affecting function. This study investigated association between variations ALDH2 levels within progression fibrosis. Our clinical data indicate that diminished are linked to worse CKD outcomes, with correlations...
Tumor suppressor in lung cancer 1 (TSLC1) is a tumor gene that encodes member of the immunoglobulin superfamily, which involved progression some types cancer. Several studies have shown loss TSLC1 expression strongly correlated to methylation promoter, thus leading poor prognosis these cancers. However, role cutaneous melanoma (CM) has not been examined. The purpose this study was understand molecular mechanisms and clinical significance inactivation CM. promoter were analyzed 120 CMs....