A5100441009- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- CRISPR and Genetic Engineering
- Escherichia coli research studies
- Cancer-related molecular mechanisms research
- Hypothalamic control of reproductive hormones
- Heme Oxygenase-1 and Carbon Monoxide
- Salmonella and Campylobacter epidemiology
- Marine Sponges and Natural Products
- Coral and Marine Ecosystems Studies
- Sperm and Testicular Function
- Congenital Ear and Nasal Anomalies
- DNA Repair Mechanisms
- S100 Proteins and Annexins
- Hemoglobin structure and function
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
- Hydrogen's biological and therapeutic effects
- Retinoids in leukemia and cellular processes
- Growth Hormone and Insulin-like Growth Factors
- Chromosomal and Genetic Variations
- Kruppel-like factors research
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Genetic Syndromes and Imprinting
Northwest A&F University
2020-2025
Nanjing Drum Tower Hospital
2024
Kunming Medical University
2024
Beijing Children’s Hospital
2018-2024
Chinese PLA General Hospital
2024
Jiangxi Agricultural University
2024
Shanghai Veterinary Research Institute
2022-2024
Shanghai University of Traditional Chinese Medicine
2014-2024
Xinjiang University
2024
Chinese Academy of Agricultural Sciences
2022-2024
Fanconi anemia (FA) genes play important roles in spermatogenesis. In mice, disruption of Fancm impairs male fertility and testicular integrity, but whether FANCM pathogenic variants (PV) similarly affect men is unknown. Here we characterize a Pakistani family having three infertile brothers, two manifesting oligoasthenospermia one exhibiting azoospermia, born to first-cousin parents. A homozygous PV (c.1946_1958del, p.P648Lfs*16) was found cosegregating with infertility. Our objective...
Farnesoid X receptor (FXR) is a nuclear hormone involved in bile acid synthesis and homeostasis. Dysfunction of FXR cholestasis atherosclerosis. prevalent liver, gallbladder, intestine, but it not yet clear whether modulates neurobehavior. In the current study, we tested hypothesis that mouse deficiency affects specific subset neurotransmitters results an unique behavioral phenotype. The knockout mice showed less depressive-like anxiety-related behavior, increased motor activity. They had...
The aim of the present study was to determine effects curcumin on osteoclastogenic potential peripheral blood mononuclear cells (PBMCs) obtained from patients with rheumatoid arthritis (RA), and investigate underlying molecular mechanisms. PBMCs RA (n=12) healthy controls (n=10) were cultured assess potential. number tartrate‑resistant acid phosphatase‑positive osteoclasts differentiated isolated significantly increased compared that controls. In addition, osteoclast in correlated clinical...
Chronic infection with liver flukes (such as Clonorchis sinensis) can induce severe biliary injuries, which cause cholangitis, fibrosis, and even cholangiocarcinoma. The release of extracellular vesicles by C. sinensis (CsEVs) is importance in the long-distance communication between hosts worms. However, biological effects EVs from fluke on injuries underlying molecular mechanisms remain poorly characterized. In present study, we found that CsEVs induced M1-like activation. addition, mice...
RAD51AP2 is required specifically for efficient meiotic recombination to form crossover between X and Y chromosomes.
Bacterial outer membrane vesicles (OMVs) contain a variety of chemical compounds and play significant roles in maintaining symbiotic relationships changing ocean, but little is known about their function, particularly sponge larval development. During the growth
This study aimed to identify insertion–deletion (InDel) variants in key genes of the Hippo signaling pathway four Chinese sheep breeds: Tong (TS), Hu (HS), Small Tail Han (STHS), and Lanzhou large-tailed (LLTS). InDel MST1/2, LATS1/2, SAV1, MOB1A/B, YAP/TAZ were screened using public databases identified through PCR amplification, gel electrophoresis, sequencing. significant associations between growth traits across breeds. Specifically, three loci MST1 gene significantly associated with...
Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1) has a wide variety therapeutic values for central nervous system (CNS) diseases the neuron protective effects. However, blood-brain barrier (BBB) restricts in reaching CNS. In this study, we investigated effects nanoparticle (PHRO, fabricated γ-PGA, L-PAE (H), Rg1, OX26 antibody), targeting transferrin receptor, on diabetes rats complicated diabetic vitro vivo. Dynamic light scattering...
Necrotic enteritis is a widespread disease in poultry caused by Clostridium perfringens. We previously reported that dietary arginine supplementation protected the intestinal mucosa of broiler chickens with necrotic enteritis, but related protective mechanisms remain unclear. The vivo trial was designed as 2 × factorial arrangement to evaluated effects on inflammatory responses, transporters, catabolism and JAK-STAT signalling pathway challenged C. perfringens or without Furthermore, we...
Multiple morphological abnormalities of the flagella (MMAF) can lead to male infertility due impaired sperm motility and morphology. Calmodulin- spoke-associated complex (CSC) are known for their roles in radial spoke (RS) assembly ciliary Chlamydomonas, while role cilia- flagella-associated protein 61 (CFAP61), a mammalian ortholog CSC subunits, humans is yet unknown. Here, we recruited three unrelated Pakistani families comprising 11 infertile patients diagnosed with MMAF.
Abstract The ventral anterior (VA) nucleus of the thalamus is a major target basal ganglia and closely associated with pathogenesis Parkinson’s disease (PD). Notably, VA receives direct innervation from hypothalamic histaminergic system. However, its role in PD remains unknown. Here, we assessed contribution histamine to neuronal activity motor deficits. Functional magnetic resonance imaging showed reduced patients. Optogenetic activation neurons or afferents significantly alleviated...
Sorafenib is associated with adverse cardiac effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish genes responsible for this cardiotoxicity using zebrafish and human cardiomyocytes. Fluorescent imaging pigmentless green fluorescent protein hearts revealed that dimensions of longitudinal axis sorafenib were significantly shorter than those control group. Transcriptome analysis their stanniocalcin 1 (stc1) was...
Curcuma zedoaria (dry stenophora of phaeocaulis Val., kwangsiensis S. G. Lee et C. F. Liang, or wenyujin Y. H. Chen C.Ling) is a representative herb with clinical effects on liver diseases after being vinegar-processed. The crude and the processed (vinegar-boil) have been widely used as mixtures, but their equivalence has not fully investigated. In this manuscript, quality markers were investigated by comparison compounds hepatoprotective activities (three spices) ones. First, GC-MS-based...
Abstract Background Patients with steroid 5α‐reductase 2 deficiency (5α‐RD) caused by SRD5A2 (OMIM #607306) variants present variable genotypes and phenotypes. The genotype‐phenotype correlations remain unclear. Methods We investigated of in a large Chinese single‐center cohort. Phenotypes were categorized using the external masculinization score (EMS), urethral meatus gonad position, penile length‐standard deviation score. Results Of 130 included patients, 113 had hypospadias, 17 normal...
The present study investigated the effects of exposure to metal oxide nanoparticles on vasculogenesis/angiogenesis using transgenic zebrafish. also examined potential mechanisms involved in those human umbilical vein endothelial cells (HUVEC). TG (nacre/fli1:EGFP) zebrafish were exposed nano-sized titanium dioxide (TiO2), silica (SiO2), and copper (CuO) particles at 0.01, 1 100 µg/ml concentrations from 5 dpf (day-post-fertilization). Angiogenesis was evaluated morphologically end exposure....
The current methods for detecting pathogenic bacteria in feed require high technique and take a long time. Micro Biological Survey (MBS) rapid detection system is simple, economical microbial method. purpose of this experiment was to compare the Escherichia coli (E. coli), Salmonella, Staphylococcus aureus (S. aureus), Listeria monocytogenes (LM), coliform (COLI) total viable count (TVC) by MBS plate counting method (PCM). results showed that limit quantitation, recovery rate coefficient...