A5007489671- Medical Imaging and Pathology Studies
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Pulmonary Hypertension Research and Treatments
- AI in cancer detection
- Cell Image Analysis Techniques
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Neonatal Respiratory Health Research
- Fibroblast Growth Factor Research
University of Southern California
2020-2025
Keck Hospital of USC
2020-2024
University of California, Los Angeles
2014-2024
Cleveland Clinic
2021-2024
USC Norris Comprehensive Cancer Center
2023
University of Ulster
2010-2022
Belfast City Hospital
2016-2022
Belfast Health and Social Care Trust
2022
LAC+USC Medical Center
2020-2021
UCLA Health
2019
In the United States, approximately 35% of adults with Systemic Lupus Erythematosus (SLE) have clinical evidence nephritis at time diagnosis; an estimated total 50–60% developing during first 10 years disease [1–4]. The prevalence is significantly higher in African Americans and Hispanics than Caucasians, men women. Renal damage more likely to develop non-Caucasian groups [2–4]. Overall survival patients SLE 95% 5 after diagnosis 92% [5, 6]. presence lupus reduces survival, 88% years, even...
The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19–23, 2013, and preceded by a 2-day Latin American Symposium Transplant Immunobiology Immunopathology. meeting highlighted the presentation of findings several working groups formed at 2009 2011 meetings to: (1) establish consensus criteria for diagnosing antibody-mediated rejection (ABMR) presence absence detectable C4d deposition; (2) develop definitions thresholds glomerulitis (g score) chronic...
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties extracellular matrix (ECM) relate to metabolic processes important PH remain undefined. In this work, we examined cultured cells various types PH-diseased lung tissue determined that ECM stiffening resulted mechanoactivation transcriptional coactivators YAP TAZ (WWTR1). YAP/TAZ activation modulated enzymes, including glutaminase...
Development of the vascular disease pulmonary hypertension (PH) involves disparate molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately regulate PH progression, but integrative functions miRNAs in this process have been challenging to define with conventional approaches. Here, analysis network architecture specific predicted miR-130/301 family is a master regulator cellular proliferation via regulation subordinate miRNA unexpected connections one another. In...
Pathology is practiced by visual inspection of histochemically stained slides. Most commonly, the hematoxylin and eosin (H&E) stain used in diagnostic workflow it gold standard for cancer diagnosis. However, many cases, especially non-neoplastic diseases, additional "special stains" are to provide different levels contrast color tissue components allow pathologists get a clearer picture. In this study, we demonstrate utility supervised learning-based computational transformation from H&E...
Abstract Purpose: A phase I study was conducted to determine safety, clinical efficacy, and antitumor immune responses in patients with advanced non–small cell lung carcinoma (NSCLC) following intratumoral administration of autologous dendritic cells (DC) transduced an adenoviral (Ad) vector expressing the CCL21 gene (Ad-CCL21-DC). We evaluated safety tumor antigen–specific situ vaccination (ClinicalTrials.gov: NCT01574222). Experimental Design: Sixteen stage IIIB/IV NSCLC subjects received...
Lung premalignancy and early-stage adenocarcinoma use a mechanism of glucose transport that can be targeted for early diagnosis treatment.
Research Article30 March 2015Open Access Source Data Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency pulmonary hypertension Kevin White Divisions Cardiovascular Medicine Network Medicine, Department Brigham Women's Hospital, Harvard Medical School, Boston, MA, USA Search for more papers by this author Yu Lu Sofia Annis Andrew E Hale B Nelson Chau Regulus Therapeutics, San Diego, CA, James Dahlman Institute Engineering Science, Massachusetts...
We have identified 25 lesions involving alveolar lung parenchyma characterized by nodular proliferation of bland bilayered bronchiolar-type epithelium containing a continuous layer basal cells. These shared some histologic features with the recently described entity ciliated muconodular papillary tumor (CMPT); however, majority did not fit all diagnostic criteria in that they exhibited only focal or absent architecture, and had variable number mucinous cells, entirely lacking 1 both these...
Context.— The adoption of digital capture pathology slides as whole slide images (WSI) for educational and research applications has proven utility. Objective.— To compare pathologists' primary diagnoses derived from WSI versus the standard microscope. Because WSIs differ in format method observation compared with current glass microscopy, this study is critical to potential clinical pathology. Design.— enrolled a total 2045 cases enriched more difficult diagnostic categories represented...
Abstract Traditional histochemical staining of post-mortem samples often confronts inferior quality due to autolysis caused by delayed fixation cadaver tissue, and such chemical procedures covering large tissue areas demand substantial labor, cost time. Here, we demonstrate virtual autopsy using a trained neural network rapidly transform autofluorescence images label-free sections into brightfield equivalent images, matching hematoxylin eosin (H&E) stained versions the same samples. The...
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epithelium; therefore, studying these critical for understanding lung carcinogenesis. Previous microarray and sequencing studies designed discover early biomarkers therapeutic targets SCC had limited success identifying key driver events carcinogenesis, mostly due cellular heterogeneity of patient samples examined interindividual variability associated with difficult obtain appropriate normal...
Background: Deficiencies of iron-sulfur (Fe-S) clusters, metal complexes that control redox state and mitochondrial metabolism, have been linked to pulmonary hypertension (PH), a deadly vascular disease with poorly defined molecular origins. BOLA3 (BolA Family Member 3) regulates Fe-S biogenesis, mutations in result multiple dysfunction syndrome, fatal disorder associated PH. The mechanistic role PH remains undefined. Methods: In vitro assessment regulation gain- loss-of-function assays were...
Scleroderma renal crisis (SRC) can lead to end-stage disease (ESRD) and subsequent need for dialysis and/or transplantation. We review all reported cases of transplantations in scleroderma patients from PubMed search, present UNOS data on transplant outcomes, identify predictors allograft SRC. Of the five with recurrent SRC, developed ESRD within a year onset native kidney whereas none those who more than 1-2 years after SRC recurrence. Anemia preceded two cases, pericardial effusion one,...
In the critically ill patient monitoring of oxygen consumption (Vo2) and carbon dioxide production (Vco2) can identify abnormalities in tissue perfusion metabolism. A patient's metabolic utilization be calculated by indirect calorimetry, once Vo2 Vco2 are measured. This paper evaluates a compact instrument designed for adult. Accuracy was measured under controlled laboratory conditions using oxygen-enriched air, PEEP, intermittent mandatory ventilation (IMV). averaged 1.3% 0.9% when room air...
Pathology and radiology form the core of cancer diagnosis, yet workflows both specialties remain ad hoc occur in separate "silos," with no direct linkage between their case accessioning and/or reporting systems, even when departments belong to same host institution. Because radiologists' pathologists' data are essential making correct diagnoses appropriate patient management treatment decisions, this isolation pathology can be detrimental quality outcomes care. These effects underscore need...