A5072674670- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Cardiovascular Issues in Pregnancy
- Vascular Anomalies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Liver Disease and Transplantation
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Organ Transplantation Techniques and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Medical Imaging and Pathology Studies
- Cardiac Arrest and Resuscitation
University of California, San Francisco
2016-2025
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
University of California San Francisco Medical Center
1994-2023
Hospital Clínic de Barcelona
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Amersham Hospital
2018
Georgia Institute of Technology
2018
Northwestern University
2018
San Francisco General Hospital
2015
We tested the hypothesis that prophylactic cardiac-resynchronization therapy in form of biventricular stimulation with a pacemaker or without defibrillator would reduce risk death and hospitalization among patients advanced chronic heart failure intraventricular conduction delays.A total 1520 who had (New York Heart Association class III IV) due to ischemic nonischemic cardiomyopathies QRS interval at least 120 msec were randomly assigned 1:2:2 ratio receive optimal pharmacologic (diuretics,...
Cardiac troponin provides diagnostic and prognostic information in acute coronary syndromes, but its role decompensated heart failure is unclear. The purpose of our study was to describe the association between elevated cardiac levels adverse events hospitalized patients with failure.We analyzed hospitalizations for October 2001 January 2004 that were recorded Acute Decompensated Heart Failure National Registry (ADHERE). Entry criteria included a level obtained at time hospitalization serum...
It remains unclear whether telemonitoring approaches provide benefits for patients with heart failure (HF) after hospitalization.To evaluate the effectiveness of a care transition intervention using remote patient monitoring in reducing 180-day all-cause readmissions among broad population older adults hospitalized HF.We randomized 1437 HF between October 12, 2011, and September 30, 2013, to arm (715 patients) or usual (722 Better Effectiveness After Transition-Heart Failure (BEAT-HF) study...
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties extracellular matrix (ECM) relate to metabolic processes important PH remain undefined. In this work, we examined cultured cells various types PH-diseased lung tissue determined that ECM stiffening resulted mechanoactivation transcriptional coactivators YAP TAZ (WWTR1). YAP/TAZ activation modulated enzymes, including glutaminase...
Remote monitoring of patients with heart failure (HF) using wearable devices can allow patient-specific adjustments to treatments and thereby potentially reduce hospitalizations. We aimed assess HF state measurements electrical mechanical aspects cardiac function in the context exercise.Patients compensated (outpatient) decompensated (hospitalized) were fitted a ECG seismocardiogram sensing patch. Patients stood at rest for an initial recording, performed 6-minute walk test, then 5 minutes...
Background Current mortality data for pulmonary arterial hypertension (PAH) in the United States are based on registries that enrolled patients prior to 2010. We sought determine PAH modern era using PHAR (Pulmonary Hypertension Association Registry). Methods and Results identified all adult with between September 2015 2020 (N=935). used Kaplan‐Meier survival analysis Cox proportional hazards models assess at 1, 2, 3 years. Patients were stratified disease severity by validated risk scores....
Background — Long-term ventricular resynchronization therapy improves symptom status. Changes in left remodeling have not been adequately evaluated. Methods and Results Fifty-three patients with systolic heart failure bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part a randomized trial. Echocardiograms were acquired at randomization 6-week intervals until completion 12 weeks continuous BVS. There no changes rate or QRS duration after Serum...
The factors that determine the risk for sudden death or implantable cardioverter defibrillator therapy in patients receiving cardiac resynchronization (CRT) therapies are largely unknown.We hypothesized clinical measures of heart failure severity and presence comorbid conditions would predict malignant arrhythmias 1520 enrolled Comparison Medical Therapy, Pacing, Defibrillation Heart Failure (COMPANION) Trial. Outcomes CRT group after were also evaluated. CRT-defibrillator device reduced by...
The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at impact diuretic dosing. 62,866 patients receiving <160 mg and 19,674 ≥160 furosemide were analyzed. lower doses had a risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies minimizing exposure high diuretics.
Circulating microparticles (MPs) are submicron membrane fragments shed from damaged or activated vascular cells. Endothelial MPs a biological marker of dysfunctional endothelium. Vascular remodeling and endothelial dysfunction involved in pulmonary hypertension (PH).We tested the hypothesis that circulating increased patients with PH identifiable subgroups predict hemodynamic severity this condition progression.Patients (n = 24; age, 54 +/- 4 yr) undergoing right heart catheterization for...
In 2005, lung allocation for transplantation in the United States changed from a system based on waiting time to Lung Allocation Score (LAS).
Moderate to severe portopulmonary hypertension (PPHTN) increases the risks of orthotopic liver transplantation (OLT). Epoprostenol is an effective treatment PPHTN, but long-term effects on pulmonary hemodynamics or function in PPHTN are poorly defined. We sought describe with without epoprostenol hemodynamics, biochemistries, and survival patients moderate at a single center. A large retrospective cohort was identified diagnosed before OLT. Baseline follow-up biochemistries were compared...
Background Long‐term corticosteroid therapy is the standard of care for treatment cardiac sarcoidosis ( CS ). The efficacy long‐term corticosteroid‐sparing immunosuppression in unknown. goal this study was to assess methotrexate with or without adalimumab disease suppression , and recurrence adverse event rates after discontinuation. Methods Results Retrospective chart review identified treatment‐naive patients at a single academic medical center who received maintenance therapy....