A5073798785- Oceanographic and Atmospheric Processes
- Cardiac Imaging and Diagnostics
- Climate variability and models
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Geology and Paleoclimatology Research
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Air Quality and Health Impacts
- Marine and coastal ecosystems
- Fluid Dynamics and Turbulent Flows
- Advanced X-ray and CT Imaging
- Heat shock proteins research
- Tropical and Extratropical Cyclones Research
- Coronary Interventions and Diagnostics
- Noise Effects and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Methane Hydrates and Related Phenomena
- Medical Imaging Techniques and Applications
- Meteorological Phenomena and Simulations
- American Constitutional Law and Politics
- Ultrasound and Hyperthermia Applications
- Ocean Waves and Remote Sensing
- Heart Failure Treatment and Management
Stony Brook University
2014-2024
State University of New York
2018-2024
University of Nevada, Reno
2023
King's College London
2023
Northern Arizona University
2022
Miami University
2022
Baker Hughes (United States)
2022
Climate and Global Dynamics Laboratory
2021
NSF National Center for Atmospheric Research
2021
Cincinnati Children's Hospital Medical Center
2017-2020
BACKGROUND Previous studies have demonstrated that heat-shock treatment results in the induction of 72-kD protein (HSP72) and a reduction infarct size after subsequent ischemia reperfusion. METHODS AND RESULTS To test hypothesis degree protection from ischemic injury heat-shocked rats correlates with prior HSP72 induction, pretreated 40 degrees C, 41 or 42 C whole-body hyperthermia followed by 24 hours recovery control (n = 6 each group) were quantitatively assessed for presence myocardial...
BACKGROUND To test the hypothesis that heat shock response is associated with improved myocardial salvage after ischemia and reperfusion, rats treated prior whole-body hyperthermia 24 hours of recovery (n = 26) or 20 minutes ischemic pretreatment 8 24) control 27, n 24, for hyperthermic pretreatment, respectively) were subjected to 35 left coronary artery (LCA) occlusion 120 reperfusion. METHODS AND RESULTS Although ventricular samples from either 7) 6) all showed induction HSP72 (heat...
Mortality is very high in lactic acidosis, and there no satisfactory treatment other than of the underlying cause. Uncontrolled studies have suggested that dichloroacetate, which stimulates oxidation lactate to acetyl-coenzyme A carbon dioxide, might reduce morbidity improve survival among patients with this condition.We conducted a placebo-controlled, randomized trial intravenous sodium dichloroacetate therapy 252 acidosis; 126 were assigned receive placebo. The entry criteria included an...
To determine the feasibility of noninvasive determination right ventricular systolic pressure (RVSP) during a graded-exercise protocol, saline contrast-enhanced Doppler echocardiography tricuspid insufficiency was performed in 36 patients with chronic lung disease and 12 normal controls. In pulmonary disease, symptom-limited, incremental supine bicycle exercise pulse oximetry were on off high-flow oxygen. Technically adequate studies initially obtained 20 (56%) at rest 14 (39%) exercise;...
Background Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an vivo model ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice overexpress HSP72 demonstrate improved functional recovery decreased vitro after global Methods Results To test the hypothesis overexpression vivo, were heterozygous for a rat HSP70i gene ([+]HSP72) transgene-negative littermate controls ([−]HSP72) subjected to...
Although previous investigators have demonstrated that myocardial preconditioning reduces infarct size, the mechanisms of cardioprotection associated with are not completely understood.To test hypothesis (four 5-minute episodes ischemia each followed by 5 minutes reperfusion) size depleting cardiac glycogen stores and attenuating degree intracellular acidosis during subsequent prolonged left coronary artery occlusion, preconditioned control rats were subjected to 45 occlusion 120 reflow...
Previous studies have demonstrated that ischemic preconditioning prevents lethal cell injury and, as a consequence, limits infarct size in rat heart. Although both apoptosis and necrosis been shown to contribute myocardial death after ischemia reperfusion, the ability of prevent programmed remains unknown.To test hypothesis reduces irreversible part by decreasing apoptosis, rats underwent controls were subjected 30 minutes left coronary artery occlusion followed 180 reperfusion. Ischemic was...
Abstract The adiabatic pole-to-pole cell of the residual overturning circulation (ROC) is studied in a two-hemisphere, semienclosed basin, with zonally reentrant channel occupying southernmost eighth domain. Three different models increasing complexity are used: simple, analytically tractable averaged model; coarse-resolution numerical model parameterized eddies; and an eddy-resolving general model. Two elements found to be necessary for existence cell: 1) thermally indirect, wind-driven...
Abstract The time-mean zonal and meridional overturning circulations of the entire Mediterranean Sea are studied in both Eulerian residual frameworks. is characterized by cells vertical either or planes with clockwise upper water column counterclockwise deep abyssal regions. composed an cell top 600 m related to classical Wüst two additional cells, one corresponding outflow dense Aegean during Eastern Transient (EMT) other associated formation Rhodes Gyre. variability before, during, after...
BACKGROUND During a 2.9-year period, 11 patients developed polymorphous ventricular tachycardia 1-13 days after acute anterior (seven patients) or inferior (four myocardial infarction. None of the had sinus bradycardia (mean heart rate, 90 +/- 23 beats/min), but three pause immediately before onset tachycardia. In all patients, QT interval and corrected (QTc) were normal minimally prolonged (QT, 385 34 msec; QTc, 442 40 msec). significant hypokalemia serum potassium concentration, 4.3 0.5...
Lyapunov vectors are natural generalizations of normal modes for linear disturbances to aperiodic deterministic flows and offer insights into the physical mechanisms flow maintenance chaos. Most standard techniques computing produce results which norm-dependent lack invariance under linearized (except leading vector) these features can make computation interpretation problematic. An efficient, norm-independent method constructing n most rapidly growing from − 1 forward backward asymptotic...
Abstract The processes maintaining stratification in the oceanic middepth (between approximately 1000 and 3000 m) are explored using an eddy-resolving general circulation model composed of a two-hemisphere, semienclosed basin with zonal reentrant channel southernmost eighth domain. region lies below wind-driven main thermocline but above diffusively driven abyssal ocean. Here, it is argued that determined primarily model’s Antarctic Circumpolar Current. Competition between mean eddy...
Early life exposure to air pollution poses a significant risk brain development from direct toxicants or via indirect mechanisms involving the circulatory, pulmonary gastrointestinal systems. In children, traffic related has been associated with adverse effects on cognitive, behavioral and psychomotor development. We aimed determine whether childhood is regional differences in volume cortical thickness among children enrolled longitudinal cohort study of child health. used magnetic resonance...
Background Although aspirin is beneficial in patients with unstable angina, it a relatively weak inhibitor of platelet aggregation. The effect Integrelin, which inhibits the fibrinogen receptor glycoprotein (GP) IIb/IIIa, on frequency and duration Holter ischemia was evaluated 227 angina. Methods Results Patients received intravenous heparin standard anti-ischemic therapy were randomized to receive oral placebo Integrelin; low-dose 45 μg/kg bolus followed by 0.5-μg·kg −1 ·min continuous...
To test the hypothesis that contrast-enhanced magnetic resonance imaging (MRI) and spectroscopy (MRS) can differentiate reversible from irreversible myocardial injury, these modalities were used to study ischemia reperfusion in a rat model. The presence of confirmed with radiolabeled microspheres (n = 6). Groups animals subjected either 16 17), 30 14), 60 11), or 90 14) minutes left coronary artery (LCA) occlusion reperfusion. After albumin-gadolinium (Gd)-DTPA injection, contrast-enhanced,...
BACKGROUND Exposure to environmental tobacco smoke (ETS) has been epidemiologically linked death from ischemic heart disease in nonsmokers. In this study, we evaluated the influence of 3 days, weeks, and 6 weeks ETS exposure on myocardial infarct size a rat ischemia/reperfusion model. METHODS AND RESULTS Sprague-Dawley rats exposed (four Marlboro cigarettes per 15 minutes, hours day, 5 days week) for (n = 24), 21), or 12) control 24, n 21, 12, respectively) were subjected 35 minutes left...
OBJECTIVE: To quantify the reported prevalence and trend of maternal hepatitis C virus (HCV) infection in United States (2009–2017) identify characteristics obstetric outcomes associated with HCV during pregnancy. METHODS: We conducted a population-based retrospective cohort study all live births for period 2009 through 2017 using National Center Health Statistics birth records. estimated trends over this time States. also evaluated demographic factors pregnancy contemporary U.S....