A5084515381- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Artificial Intelligence in Healthcare and Education
- Acute Ischemic Stroke Management
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Blood Coagulation and Thrombosis Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Blood properties and coagulation
- Platelet Disorders and Treatments
Scripps Health
2011-2025
Scripps Research Institute
2016-2025
Scripps Institution of Oceanography
2014-2025
Scripps (United States)
2009-2025
Scripps Clinic
2012-2024
Stanford University
1992-2024
University College London
1995-2023
Universidade Federal de São Paulo
2023
Protein Metrics (United States)
2023
Tulane University
2023
The relative efficacy of streptokinase and tissue plasminogen activator the roles intravenous as compared with subcutaneous heparin adjunctive therapy in acute myocardial infarction are unresolved questions. current trial was designed to compare new, aggressive thrombolytic strategies standard regimens treatment infarction. Our hypothesis that newer produce earlier sustained reperfusion would improve survival.
SPIRIN IS A CORNERSTONE OF therapy for patients undergoing coronary intervention.Its use is considered a standard of care before the procedure and lifelong following revascularization.2][3][4] However, optimal timing initiation clopidogrel aspirin, as well their duration treatment PCI procedure, remains unknown.][7] Despite consistency this observation, patient or procedural characteristics may have biased results in
Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events.
To assess the likelihood of procedural success in patients with multivessel coronary disease undergoing percutaneous angioplasty, 350 consecutive (1,100 stenoses) from four clinical sites were evaluated. Eighteen variables characterizing severity and morphology each stenosis 18 patient-related assessed at a core angiographic laboratory sites. Most had Canadian Cardiovascular Society class III or IV angina (72%) two-vessel (78%). Left ventricular function was generally well preserved (mean...
High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined.To evaluate the effect of high-dose compared with standard-dose in patients high on-treatment PCI.Randomized, double-blind, active-control trial (Gauging Responsiveness A VerifyNow assay-Impact on Thrombosis And Safety [GRAVITAS]) 2214 12 24 hours PCI drug-eluting stents at 83 centers North...
Context The direct thrombin inhibitor bivalirudin has been associated with better efficacy and less bleeding than heparin during coronary balloon angioplasty but not widely tested contemporary percutaneous intervention (PCI). Objective To determine the of bivalirudin, glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibition on a provisional basis for complications PCI, compared plus planned Gp blockade regard to protection from periprocedural ischemic hemorrhagic complications. Design, Setting,...
ContextThe effect of antihypertensive drugs on cardiovascular events in patients with coronary artery disease (CAD) and normal blood pressure remains uncertain.ObjectiveTo compare the effects amlodipine or enalapril vs placebo CAD.Design, Setting, ParticipantsDouble-blind, randomized, multicenter, 24-month trial (enrollment April 1999-April 2002) comparing 1991 angiographically documented CAD (>20% stenosis by angiography) diastolic <100 mm Hg. A substudy 274 measured atherosclerosis...
The prognosis of patients hospitalized with acute myocardial ischemia is quite variable. We examined the value serum levels cardiac troponin T, creatine kinase MB (CK-MB) levels, and electrocardiographic abnormalities for risk stratification in ischemia.
Background Despite remarkable advances in the treatment of acute myocardial infarction, substantial early patient mortality remains. Appropriate choices among alternative therapies and use clinical resources depend on an estimate patient’s risk. Individual patients reflect a combination features that influence prognosis, these factors must be appropriately weighted to produce accurate assessment Prior studies define prognosis either were performed before widespread thrombolysis or limited...
Inflammation is linked to adverse outcomes in acute coronary syndromes. Myeloperoxidase, an abundant leukocyte enzyme, elevated culprit lesions that have fissured or ruptured patients with sudden death from cardiac causes. Numerous lines of evidence suggest mechanistic links between myeloperoxidase and both inflammation cardiovascular disease.