A5103024110- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Sepsis Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Effects of Exercise
Johns Hopkins University
2014-2023
Johns Hopkins Medicine
2013-2023
Johns Hopkins Hospital
2011-2023
HJF Medical Research International
2021
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Canadian Sleep Society
2018
Doctors Company (United States)
2017
University of Louisville
2014-2015
University of Maryland, Baltimore
2014
Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown.
Background —The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions profound at infarct core are hypoenhanced correspond to greater acutely. We investigated whether infarction predicts 2-year cardiovascular morbidity mortality. Methods Results —Forty-four patients underwent MRI 10±6 days Microvascular was defined as hypoenhancement seen 1 2...
Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, it has an important role in platelet aggregation. It known to be involved the pathogenesis of acute coronary syndromes. Previously, we found high frequency particular polymorphism, Pl A2 , gene encoding IIIa kindreds with prevalence premature myocardial infarction.
To examine whether age differentially modifies the physiological response to exercise in men and women, we performed gated radionuclide ventriculography with measurement of left ventricular volumes at rest during peak upright cycle 200 rigorously screened healthy sedentary volunteers (121 79 women) aged 22–86 yr from Baltimore Longitudinal Study Aging. At sitting position, age-associated declines heart rate (HR) increases systolic blood pressure occurred both sexes. Whereas resting cardiac...
Background Myocardial reperfusion is pivotal to the prognosis of patients with acute myocardial infarction. In these patients, coronary flow generally assessed by angiography and tissue perfusion tracer scintigraphy. This study was designed examine whether magnetic resonance imaging (MRI) provides information on damage beyond that supplied thallium scintigraphy after Methods Results Twenty-two recent infarction had ECG, echocardiography, angiography, fast contrast-enhanced MRI. Twelve also...
The amino acid L-arginine is a substrate for nitric oxide synthase and increasingly used as health supplement. Prior studies suggest that has the potential to reduce vascular stiffness.To determine whether addition of standard postinfarction therapy reduces stiffness improves ejection fraction over 6-month follow-up in patients following acute ST-segment elevation myocardial infarction.Single-center, randomized, double-blind, placebo-controlled trial with enrollment from February 2002 June...
Although accumulating data support the efficacy of intramyocardial cell-based therapy to improve left ventricular (LV) function in patients with chronic ischemic cardiomyopathy undergoing CABG, underlying mechanism and impact cell injection site remain controversial. Mesenchymal stem cells (MSCs) LV structure through several effects including reducing fibrosis, neoangiogenesis, neomyogenesis.To test hypothesis that on cardiac after injections autologous MSCs results from a concordance...
Background Clinical investigations of shock in cardiac intensive care units (CICUs) have primarily focused on acute myocardial infarction (AMI) complicated by cardiogenic (AMICS). Few studies evaluated the full spectrum contemporary CICUs. Methods and Results The Critical Care Cardiology Trials Network is a multicenter network advanced CICUs North America. Anytime between September 2017 2018, each center (n=16) contributed 2-month snap-shot all consecutive medical admissions to CICU. Data...
Single-center and claims-based studies have described substantial changes in the landscape of care cardiac intensive unit (CICU). Professional societies recommended research to guide evidence-based CICU redesigns.To characterize patients admitted contemporary, advanced CICUs.This study established Critical Care Cardiology Trials Network (CCCTN), an investigator-initiated multicenter network 16 advanced, tertiary CICUs United States Canada. For 2 months each CICU, data for consecutive...
Left ventricular mass sometimes decreases during treatment of hypertension, but this response is inconsistent and its effects on left function are unknown. In a six-month randomized trial, we studied the ability verapamil atenolol to reduce in 42 elderly patients with hypertension reduction cardiac function.
Background— The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. Methods and Results— We measured myocardial creatine kinase (CK) metabolite concentrations adenosine triphosphate (ATP) synthesis through CK, the primary reserve heart, test hypothesis that ATP flux CK is impaired patients with LVH CHF. Myocardial levels were normal, but phosphate 35% lower (n=10) than normal...
Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single or specific etiologies of shock, limiting data regarding overall practice patterns with temporary MCS in cardiac intensive care units.The CCCTN (Critical Care Cardiology Trials Network) is a multicenter network tertiary CICUs North America. Between September 2017 and 2018, each center (n=16) contributed 2-month...
The cardiovascular response to beta-adrenergic stimulation is markedly blunted with advancing age, and this blunting may underlie some of the prominent age-associated changes in hemodynamic profile during dynamic exercise. To examine hypothesis, we administered nonselective receptor blocker propranolol (0.15 mg/kg IV) 25 healthy normotensive men ages 28 72 years from Baltimore Longitudinal Study Aging (BLSA) immediately before maximal upright cycle ergometry 99mTc gated cardiac blood pool...
Physiologic changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) across trimesters of pregnancy have not been well studied. The authors aimed to measure NT-proBNP adult women, by status and trimester, a nationally representative sample from the National Health Nutrition Examination Survey 1999 2004. We conducted cross-sectional analysis 2,134 women (546 pregnant) aged 20 40 years without history cardiovascular disease. Among pregnant first prevalence elevated (>125 pg/mL) was...
Background Although aspirin is beneficial in patients with unstable angina, it a relatively weak inhibitor of platelet aggregation. The effect Integrelin, which inhibits the fibrinogen receptor glycoprotein (GP) IIb/IIIa, on frequency and duration Holter ischemia was evaluated 227 angina. Methods Results Patients received intravenous heparin standard anti-ischemic therapy were randomized to receive oral placebo Integrelin; low-dose 45 μg/kg bolus followed by 0.5-μg·kg −1 ·min continuous...
The influence of metabolic substrate on contractile strength, myocardial oxygen consumption (MVO2), high- and low-energy phosphate levels, intracellular pH were determined in isovolumically contracting isolated rat hearts perfused with solutions containing either glucose or hexanoate at both high low coronary perfusion pressures (CPP). Contractile strength was not significantly influenced by a CPP 80 mmHg. As flow decreased, developed pressure measured fixed left ventricular volume (LVV)...
The extent to which a preference for less aggressive care explains the lower rate of invasive cardiac services women and African-Americans is unknown. A prospective observational study 272 patients admitted coronary unit was conducted at tertiary referral teaching hospital community hospital. In stepwise multivariate analysis, having than college education, poor function, not undergone previous catheterization, being patient in nonreferral hospital, current smoking were positively associated...