A5047535051- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Cardiac pacing and defibrillation studies
- COVID-19 Clinical Research Studies
- Non-Invasive Vital Sign Monitoring
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Toxin Mechanisms and Immunotoxins
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Emergency and Acute Care Studies
- Health Systems, Economic Evaluations, Quality of Life
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Ion Channels and Receptors
- Viral Infections and Immunology Research
MedStar Washington Hospital Center
2020-2025
MedStar Heart & Vascular Institute
2019-2024
MedStar Georgetown University Hospital
2023
Georgetown University
2023
Washington Hospital
2019-2022
Thrombolysis in Myocardial Infarction Study Group
2022
Brigham and Women's Hospital
2022
University of California, San Francisco
2019-2020
Gentofte Hospital
2020
University of California San Francisco Medical Center
2019
A mutation in ORAI1, the gene encoding pore-forming subunit of Ca(2+)-release-activated Ca(2+) (CRAC) channel, abrogates store-operated entry into cells and impairs lymphocyte activation. Stromal interaction molecule 1 (STIM1) endoplasmic reticulum activates ORAI1-CRAC channels. We report on three siblings from one kindred with a clinical syndrome immunodeficiency, hepatosplenomegaly, autoimmune hemolytic anemia, thrombocytopenia, muscular hypotonia, defective enamel dentition. Two these...
Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single or specific etiologies of shock, limiting data regarding overall practice patterns with temporary MCS in cardiac intensive care units.The CCCTN (Critical Care Cardiology Trials Network) is a multicenter network tertiary CICUs North America. Between September 2017 and 2018, each center (n=16) contributed 2-month...
Abstract The analysis of submicroscopic copy number variations (CNVs), also known as polymorphisms (CNPs), is emerging a new tool for understanding the genetic basis cancer, developmental disorders, and complex traits. One area where this may be particularly useful in identification variants underlying schizophrenia (SZ) bipolar disorder (BD). Linkage pharmacological studies carried out over past decade have implicated positional physiological candidate genes. Yet, despite extensive...
Abstract Aims Invasive haemodynamic assessment with a pulmonary artery catheter is often used to guide the management of patients cardiogenic shock (CS) and may provide important prognostic information. We aimed assess associations relationships end-organ dysfunction presenting parameters in CS. Methods results The Critical Care Cardiology Trials Network an investigator-initiated multicenter registry cardiac intensive care units (CICUs) North America coordinated by TIMI Study Group. Patients...
Abstract Aims The aims of the Critical Care Cardiology Trials Network (CCCTN) are to develop a registry investigate epidemiology cardiac critical illness and establish multicentre research network conduct randomised clinical trials (RCTs) in patients with illness. Methods results CCCTN was founded 2017 16 centres has grown over 40 academic United States Canada. Each centre enters data for consecutive intensive care unit (CICU) admissions at least 2 months each calendar year. More than 20 000...
BackgroundAcute heart failure (HF) is an important complication of coronavirus disease 2019 (COVID-19) and has been hypothesized to relate inflammatory activation.MethodsWe evaluated consecutive intensive care unit (ICU) admissions for COVID-19 across 6 centers in the Critical Care Cardiology Trials Network, identifying patients with vs without acute HF. Acute HF was subclassified as de novo acute-on-chronic, based on absence or presence prior Clinical features, biomarker profiles outcomes...
BACKGROUND: Wide interhospital variations exist in cardiovascular intensive care unit (CICU) admission practices and the use of critical restricted therapies (CCRx), but little is known about differences patient acuity, CCRx utilization, associated outcomes within tertiary centers. METHODS: The Critical Care Cardiology Trials Network a multicenter registry academic CICUs United States Canada that captured consecutive admissions 2-month periods between 2017 2022. This analysis included 17 843...
Sex disparities exist in the management and outcomes of various cardiovascular diseases. However, little is known about sex differences cardiogenic shock (CS). We sought to assess sex-related characteristics, resource utilization, patients with CS.
Background: Algorithmic application of the 2019 Society Cardiovascular Angiography and Intervention (SCAI) shock stages effectively stratifies mortality risk for patients with cardiogenic shock. However, clinician assessment SCAI staging may differ. Moreover, implications 2022 criteria update remain incompletely defined. Methods: The Critical Care Cardiology Trials Network is a multicenter registry cardiac intensive care units (CICUs). Between 2021, participating centers (n=32) contributed...
Abstract Aims The Shock Academic Research Consortium (SHARC) recently proposed pragmatic consensus definitions to standardize classification of cardiogenic shock (CS) in registries and clinical trials. We aimed describe contemporary CS epidemiology using the SHARC a cardiac intensive care unit (CICU) population. Methods results Critical Care Cardiology Trials Network (CCCTN) is multinational research network advanced CICUs coordinated by TIMI Study Group (Boston, MA). Cardiogenic was defined...
Syncope refers to a transient loss of consciousness and postural tone secondary cerebral hypoperfusion. Guidelines recommend against neurovascular testing in cases syncope without neurologic symptoms; however, many pursue carotid artery duplex ultrasonography (CUS) due the prognostic implications identified cerebrovascular disease. Our objective was determine diagnostic utility CUS evaluation identification new or severe atherosclerosis with potential change patient management.We reviewed...
Abstract Despite limitations in sensitivity and specificity, estimation of the pulmonary artery systolic pressure (ePASP) on echocardiography is used for portopulmonary hypertension (PoPH) screening liver transplant (LT) candidates. We proposed that alternative echocardiographic models, such as estimated vascular resistance (ePVR), may provide improved testing characteristics PoPH screening. In a retrospective analysis 100 LT candidates, we found formula ePVR = ePASP/VTI RVOT + 3 if MSN (VTI...