A5013391906- HIV Research and Treatment
- Renal Diseases and Glomerulopathies
- HIV/AIDS drug development and treatment
- Genetic and Kidney Cyst Diseases
- Chronic Kidney Disease and Diabetes
- HIV/AIDS Research and Interventions
- Reproductive System and Pregnancy
- Viral gastroenteritis research and epidemiology
- Cardiac Imaging and Diagnostics
- Immune Cell Function and Interaction
- Bioactive Compounds and Antitumor Agents
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Crystallography and molecular interactions
- Bipolar Disorder and Treatment
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Virology and Viral Diseases
- Adenosine and Purinergic Signaling
- Protein Kinase Regulation and GTPase Signaling
- Crystallization and Solubility Studies
OpenAI (United States)
2025
Department of Biotechnology
2016-2024
Jamia Millia Islamia
2015-2024
Jamia Hamdard
2019
Indraprastha Apollo Hospitals
2017
Toronto Public Health
2011-2016
Feinstein Institute for Medical Research
2008-2014
Hofstra University
2013
Northwell Health
2009-2013
University of Bristol
2012
Abstract We investigated an outbreak of encephalitis in Tangail District, Bangladesh. defined case-patients as persons from the area whom fever developed with new onset seizures or altered mental status December 15, 2004, through January 31, 2005. Twelve met definition; 11 (92%) died. Serum specimens were available 3; 2 had immunoglobulin M antibodies against Nipah virus by capture enzyme immunoassay. enrolled and 33 neighborhood controls a case-control study. The only exposure significantly...
Abstract Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin extensively-studied anti-cancer compound, however, role in affecting metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) a variety cell lines by down-regulating PKM2 expression, via inhibition mTOR-HIF1α axis. Stable silencing revealed required for proliferation cells. over-expression...
Naringenin (NAR), a flavonoid mainly found in citrus and grapefruits, has proven anti-cancer activities. However, the poor water solubility low bioavailability of NAR limits its use as therapeutic agent. The aim this study was to develop optimize stable naringenin nanoemulsions (NAR-NE) using Box-Behnken experimental design obtain formulation with higher efficiency. Anticancer activity optimized NAR-NE evaluated A549 lung cancer cells cell viability, flow-cytometric assays, enzyme-linked...
In collapsing focal segmental glomerulosclerosis (FSGS) of HIV-associated nephropathy (HIVAN), podocytes exhibit a high proliferation rate and loss differentiation markers. We have found previously that the nef gene HIV-1 is responsible for these changes. Here, we investigated signaling pathways induced by Nef its role in pathogenesis HIVAN. Using conditionally immortalized after differentiation, infection with increased Src kinase activity signal transducer activator transcription 3 (Stat3)...
ABSTRACT. HIV-associated nephropathy (HIVAN) is now the third leading cause of end-stage renal disease in African American population. HIV-1 infects tubular and glomerular epithelial cells or podocytes, that are a critical part filtration barrier. infection induces loss podocyte differentiation markers increases proliferation. It has been previously shown HIV-infection contact inhibition. Here, gene responsible for proliferative changes identified by using cultured podocytes vitro. The...
In collapsing focal segmental glomerulosclerosis (FSGS) of HIV-associated nephropathy (HIVAN), podocytes exhibit a high proliferation rate and loss differentiation markers. We have found previously that the nef gene HIV-1 is responsible for these changes. Here, we investigated signaling pathways induced by Nef its role in pathogenesis HIVAN. Using conditionally immortalized after differentiation, infection with increased Src kinase activity signal transducer activator transcription 3 (Stat3)...
Resveratrol (RES) is a polyphenolic compound which has shown beneficial pharmacological effects such as anti-inflammatory, antioxidant, and anti-cancer effects. However, poor aqueous solubility, bioavailability, low stability are the major limitations to clinical application of RES. Therefore, in present study, chitosan (CS) coated PLGA nanoparticles RES (CS-RES-PLGA NPs) was developed, characterized its anticancer activity evaluated H1299 lung carcinoma cell line. The increase CS coating...
Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and vivo. However, the clinical application PLM been hindered due to poor aqueous solubility low bioavailability. The aim present study was develop, optimize evaluate PLM-loaded glycerosome (GM) gel compare with conventional liposome (CL) for therapeutic efficacy skin cancer. GM formulations were optimized by employing design expert software 3-level 3-factor design. prepared GMs...
To determine the specific role of Nef in pathogenesis HIV-associated nephropathy.Podocytes are highly differentiated non-dividing cells normal glomerulus, however, they undergo dedifferentiation and acquire a proliferative phenotype HIVAN patients, HIV-transgenic mice if infected by HIV-1 vitro. These changes accompanied loss maturation markers synaptopodin WT1, expression proliferation marker Ki-67. Previously, we mapped gene responsible for these vitro to Nef. vivo, developed transgenic...
HIV-associated nephropathy is characterized by renal podocyte proliferation and dedifferentiation. This study found that all-trans retinoic acid (atRA) reverses the effects of HIV-1 infection in podocytes. Treatment with atRA reduced cell rate causing G1 arrest restored expression differentiation markers (synaptopodin, nephrin, podocin, WT-1) HIV-1-infected It interesting both 9-cis RA increased intracellular cAMP levels Podocytes expressed most isoforms receptors (RAR) retinoid X (RXR)...
Abstract The treatments available for non‐small cell lung cancer exert various side effects in patients, and the burden of treatment cost is high. Therefore, exploring alternative system medicines, including therapies based on natural compounds, has become inevitable developing anticancer therapeutics. This study used an integrated approach involving in‐silico in‐vitro methods to explore compounds targeting Bax Bcl2 their apoptotic potential. Molecular docking followed by molecular dynamics...
We report an efficient sustainable two-step anion exchange synthetic procedure for the preparation of choline API ionic liquids (Cho-API-ILs) that contain active pharmaceutical ingredients (APIs) as anions combined with choline-based cations. have evaluated in vitro cytotoxicity synthesized compounds using three different cells lines, namely, HEK293 (normal kidney cell line), SW480, and HCT 116 (colon carcinoma cells). The solubility APIs Cho-API-ILs was water/buffer solutions found higher...
Dysregulated apoptosis of renal tubular epithelial cells (RTEC) is an important component the pathogenesis several diseases, including HIV-associated nephropathy (HIVAN), most common cause chronic kidney failure in HIV-infected patients. In HIVAN, RTEC become infected by HIV-1 a focal distribution, and infection has been shown to induce vitro. microarray studies that used novel cell line from patient with it was found ubiquitin-like protein FAT10 one upregulated genes cells. Previously,...
Apoptotic evasion by cancerous cells being one of the striking hallmarks cancer has turned into a new arena drug discovery. A large number pathways reported that govern apoptotic have been reported. Fas-activated serine/threonine kinase (FASTK) is member Ser/Thr family, and it implicated in and, hence, development cancer. Keeping this view, series novel thienopyrimidine-based chalcones synthesized evaluated to modulate FASTK mediated evasion. Initial screening was done enzyme inhibition...
Multi-purpose Large Language Models (LLMs), a subset of generative Artificial Intelligence (AI), have recently made significant progress. While expectations for LLMs to assist systems engineering (SE) tasks are paramount; the interdisciplinary and complex nature systems, along with need synthesize deep-domain knowledge operational context, raise questions regarding efficacy generate SE artifacts, particularly given that they trained using data is broadly available on internet. To end, we...
ABSTRACT Multi‐purpose large language models (LLMs), a subset of generative artificial intelligence (AI), have recently made significant progress. While expectations for LLMs to assist systems engineering (SE) tasks are paramount; the interdisciplinary and complex nature systems, along with need synthesize deep‐domain knowledge operational context, raise questions regarding efficacy generate SE artifacts, particularly given that they trained using data is broadly available on internet. To...