A5033734504- Sports injuries and prevention
- Plant and animal studies
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Renal Diseases and Glomerulopathies
- Shoulder Injury and Treatment
- Ecology and Vegetation Dynamics Studies
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Advanced Wireless Communication Techniques
- Spinal Fractures and Fixation Techniques
- Sports Performance and Training
- HIV Research and Treatment
- Error Correcting Code Techniques
- Plant Reproductive Biology
- Muscle activation and electromyography studies
- Animal Ecology and Behavior Studies
- Lower Extremity Biomechanics and Pathologies
- Cervical and Thoracic Myelopathy
- Chronic Kidney Disease and Diabetes
- HIV/AIDS drug development and treatment
- Tendon Structure and Treatment
- Innovations in Medical Education
- Wireless Communication Networks Research
- Myofascial pain diagnosis and treatment
Daemen College
2015-2024
RELX Group (United States)
2023
Panthera Corporation
2022
University of Cape Town
2022
Harvard University
1969-2021
Detroit Historical Society
2021
Boston Children's Hospital
2021
Broad Institute
2021
St Michael's Hospital
2019
Center for Translational Molecular Medicine
2016-2017
African Americans have higher rates of kidney disease than European Americans. Here, we show that, in Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage (H-ESKD) are associated with two independent sequence variants the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD 7.3 (95% CI 5.6 9.5)}. The common chromosomes but absent from chromosomes, both reside within haplotypes that harbor signatures...
Abstract. The striking emergence of an epidemic HIV-related renal disease in patients with end-stage provided the rationale for exploration whether HIV-1 directly infects parenchymal cells. Renal glomerular and tubular epithelial cells contain mRNA DNA, indicating infection by HIV-1. In addition, circularized viral a marker recent nuclear import full-length, reverse-transcribed RNA, was detected biopsies, suggesting active replication tissue. Infiltrating infected leukocytes harbored more...
Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and now third leading end-stage blacks 20 to 64 years age.1,2 These typically have proteinuria followed by a reduction glomerular filtration rate that progresses few weeks or months. HIV-1–associated characterized morphologically focal segmental glomerulosclerosis, tubular microcysts, interstitial fibrosis, inflammation.2–5 The pathogenesis poorly...
Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 distributions on kidney allograft outcomes. We conducted a retrospective analysis 119 AA transplant recipients, and found that 58 (48.7%) carried two risk variants. Contrary to association seen native disease, there is no difference survival at 5-year posttransplant for recipients high-risk genotypes. Thus, were able conclude...
Although APOL1 gene variants are associated with nephropathy in African Americans, little is known about protein synthesis, uptake, and localization kidney cells. To address these questions, we examined mRNA human kidney-derived cell lines. Indirect immunofluorescence microscopy performed on nondiseased nephrectomy cryosections from persons normal function revealed that was markedly enriched podocytes (colocalized synaptopodin Wilms' tumor suppressor) present lower abundance renal tubule...
Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) poised to address these challenges. study has enrolled >850 pediatric adult patients with proteinuric glomerular who have contributed deep clinical, histologic, genetic, profiles...
The purpose of this study was to determine the test-retest reliability 4 single-leg horizontal hop tests (i.e., single for distance, triple crossover and 6-m time), with a time interval approximately weeks separating 2 testing sessions. Eighteen healthy, young, adult men, all cadets enrolled at U.S. Air Force Academy, Colorado, performed during sessions separated by 31.2 +/- 0.4 days. Reliability data each were studied through repeated measures analysis variance, intraclass correlation...
ABSTRACT. HIV-associated nephropathy (HIVAN) is now the third leading cause of end-stage renal disease in African American population. HIV-1 infects tubular and glomerular epithelial cells or podocytes, that are a critical part filtration barrier. infection induces loss podocyte differentiation markers increases proliferation. It has been previously shown HIV-infection contact inhibition. Here, gene responsible for proliferative changes identified by using cultured podocytes vitro. The...
It appears that subdioecy in the seed plants has evolved repeatedly, by at least five evolutionary pathways. These are: (1) from hermaphroditism via gynodioecy; (2) monoecy; (3) distyly; (4) andromonoecy and androdioecy; (5) directly hermaphroditism. Pathway 5 been little studied. This paper summarizes evidence for pathways, gives a genetic model which represents both hermaphrodite or monoecious populations, their direct differentiation toward dioecy. is emphasized there morphological,...
Journal Article THE EVOLUTION OF GYNODIOECY AND SUBDIOECY Get access M. D. Ross Genetics Unit, Grasslands Division DSIR Palmerston North New Zealand Search for other works by this author on: Oxford Academic Google Scholar Evolution, Volume 32, Issue 1, 1 March 1978, Pages 174–188, https://doi.org/10.1111/j.1558-5646.1978.tb01107.x Published: 01 1978 history Received: 27 July 1976 Revision received: 04 1977
Polymorphisms in APOL1 are associated with CKD, including HIV-related individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized kidney cells, but the contribution location to CKD pathogenesis unclear. We examined associations plasma levels cytokine levels, dyslipidemia, genotype a nested case-control study (n=270) HIV-infected Americans enrolled multicenter prospective observational study. Patients were designated as having when estimated GFR (eGFR)...
HIV-associated nephropathy (HIVAN) is characterized by collapsing FSGS. Because transgenic mice with podocyte-specific overexpression of the vascular endothelial growth factor 164 (VEGF164) isoform also develop FSGS, we sought to determine whether VEGF plays a role in HIVAN. Compared controls, immunohistochemistry revealed that kidneys from HIV-1-transgenic (Tg26) and patients HIVAN had greater expression both its transcriptional regulator, hypoxia-inducible 2alpha (HIF-2alpha). Similarly,...
The purpose of this study is to assess the relationship between functional levels in activities daily living and sports fear-avoidance beliefs patients with a history anterior cruciate ligament reconstruction (ACLR), after controlling for injury-related variables physical impairment measures. Forty-eight subjects (34 men, 14 women; age 20.6 ± 1.2 years), at mean 31.7 16.2 months following ACLR, participated study. Functional were assessed Knee Outcome Survey (KOS) Activities Daily Living...
Journal Article EVOLUTION OF DIOECY FROM GYNODIOECY Get access M. D. Ross Department of Biology Dalhousie University Halifax Nova Scotia Canada Search for other works by this author on: Oxford Academic Google Scholar Evolution, Volume 24, Issue 4, 1 December 1970, Pages 827–828, https://doi.org/10.1111/j.1558-5646.1970.tb01820.x Published: 01 1970 history Received: 18 February
Abstract. Human immunodeficiency virus—associated nephropathy (HIVAN) affects up to 10% of HIV-positive black adults and children is the leading cause renal disease in infected individuals. The characterized by proliferation epithelial cells, both glomerular tubular. Diseased kidneys are enlarged, visceral cells (podocytes) express markers. In a transgenic murine model HIVAN expressing deletion construct HIV-1, identical pathologic features observed. It was demonstrated that HIV-1 mRNA...
Summary: HIV-associated nephropathy (HIVAN) is the most common cause of chronic renal failure in HIV-infected patients. Tubulointerstitial inflammation a prominent component histopathology HIVAN. The pathogenesis HIVAN result infection epithelial cells, but cellular response to this remains poorly defined. In these studies, we used oligonucleotide microarrays identify differentially expressed genes tubular cells from patient with at three time points after vesicular stomatitis...
Dysregulated apoptosis of renal tubular epithelial cells (RTEC) is an important component the pathogenesis several diseases, including HIV-associated nephropathy (HIVAN), most common cause chronic kidney failure in HIV-infected patients. In HIVAN, RTEC become infected by HIV-1 a focal distribution, and infection has been shown to induce vitro. microarray studies that used novel cell line from patient with it was found ubiquitin-like protein FAT10 one upregulated genes cells. Previously,...
ABSTRACT General conditions for the protectedness of gene-cytoplasm polymorphisms are considered a biallelic model with two cytoplasm types and under assumption that nuclear cannot be maintained in presence only one type. Analytical results involving male fertilities, female viabilities selfing rates obtained, numerical show spiral cyclic behavior population trajectories. It is shown maternally inherited cytoplasmic polymorphism absence polymorphism, can if shows sexual asymmetry, i.e.,...