Frederick J. Kaskel
A5015027317- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Biomedical Research and Pathophysiology
- Adolescent and Pediatric Healthcare
- Electrolyte and hormonal disorders
- Renal and related cancers
- Acute Kidney Injury Research
- Metabolism and Genetic Disorders
- Ion Transport and Channel Regulation
- Neonatal Health and Biochemistry
- Pediatric Urology and Nephrology Studies
- Renal function and acid-base balance
- Childhood Cancer Survivors' Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Pharmacological Effects and Toxicity Studies
- Neonatal Respiratory Health Research
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Autoimmune Bullous Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
Children's Hospital at Montefiore
2015-2024
Albert Einstein College of Medicine
2015-2024
Colorado Kidney Care
2024
Montefiore Medical Center
2013-2022
Harvard University
1987-2021
University of Michigan
2020-2021
Cornell University
2021
Beth Israel Deaconess Medical Center
2021
Yeshiva University
2003-2020
University of Arkansas for Medical Sciences
2020
The Schwartz formula was devised in the mid-1970s to estimate GFR children. Recent data suggest that this currently overestimates as measured by plasma disappearance of iohexol, likely a result change methods used measure creatinine. Here, we developed equations using from baseline visits 349 children (aged 1 16 yr) Chronic Kidney Disease Children (CKiD) cohort. Median iohexol-GFR (iGFR) 41.3 ml/min per 1.73 m(2) (interquartile range 32.0 51.7), and median serum creatinine 1.3 mg/dl. We...
To determine the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency and associations between 25(OH)D cardiovascular risk factors in children adolescents.With a nationally representative sample aged 1 to 21 years National Health Nutrition Examination Survey 2001-2004 (n = 6275), we measured serum insufficiency (25[OH]D <15 ng/mL 15-29 ng/mL, respectively) factors.Overall, 9% pediatric population, representing 7.6 million US adolescents, were deficient 61%, 50.8 insufficient. Only 4% had...
An estimated 650,000 Americans will have ESRD by 2010. Young adults with kidney failure often develop progressive chronic disease (CKD) in childhood and adolescence. The Chronic Kidney Disease Children (CKiD) prospective cohort study of 540 children aged 1 to 16 yr GFR between 30 75 ml/min per 1.73 m2 was established identify novel risk factors for CKD progression; the impact function decline on growth, cognition, behavior; evolution cardiovascular factors. Annually, a physical examination...
Overexpression of soluble urokinase receptor (suPAR) causes pathology in animal models similar to primary FSGS, and one recent study demonstrated elevated levels serum suPAR patients with the disease. Here, we analyzed circulating two cohorts children adults biopsy-proven FSGS: 70 from North America–based FSGS clinical trial (CT) 94 PodoNet, Europe-based consortium studying steroid-resistant nephrotic syndrome. Circulating were 84.3% 55.3% CT PodoNet cohorts, respectively, compared 6%...
Cystinosis is caused by mutations in the CTNS gene (17p13.2), which encodes for a lysosomal cystine/proton symporter termed cystinosin. It most common cause of inherited renal Fanconi syndrome young children. Because its rarity, diagnosis and specific treatment cystinosis are frequently delayed, has significant impact on overall prognosis. In this document, we have summarized expert opinions several aspects disease to improve knowledge provide guidance treatment.
The application of deep learning for automated segmentation (delineation boundaries) histologic primitives (structures) from whole slide images can facilitate the establishment novel protocols kidney biopsy assessment. Here, we developed and validated networks structures on biopsies nephrectomies. For development, examined 125 Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 stained Hematoxylin & Eosin (125), Periodic Acid Schiff Silver (102), Trichrome...
Ischemia-reperfusion injury in cadaveric (CAD) kidney allografts is associated with tubular cell injury, delayed graft function, and an increased incidence of acute chronic rejection. We tested the hypothesis that activation specific apoptotic pathways represents a mechanism for death after CAD transplantation.Serial tissue sections from paraffin-embedded needle biopsy specimens obtained at approximately 1 hr reperfusion transplantation 13 12 living-related donor (LRD) renal were examined by...
Summary Background and objectives FSGS histologic variants have correlated with outcomes in retrospective studies. The Clinical Trial provided a unique opportunity to study the clinical impact of well defined prospective cohort steroid-resistant primary FSGS. Design, setting, participants, & measurements Renal biopsies 138 participants aged 2–38 years enrolled from 2004 2008 were analyzed using Columbia classification by core pathologists. This assessed distribution examined their biopsy...
Background and objectives Metabolic abnormalities cardiovascular disease (CVD) risk factors have rarely been systematically assessed in children with chronic kidney (CKD). We examined the prevalence of various CKD sequelae across GFR spectrum. Design, setting, participants, & measurements Data were used from 586 participating Chronic Kidney Disease Children (CKiD) study (United States Canada) measured by iohexol plasma disappearance. Laboratory values CVD compared categories an age-,...
In many disorders requiring steroid therapy, there is substantial decrease in bone mineral density. The association between use and 25-hydroxyvitamin D [25(OH)D] deficiency has not been confirmed large population-based studies, currently are no specific vitamin recommendations for users.The aim of the study was to evaluate serum 25(OH)D [defined as <10 ng/ml] with oral use.Cross-sectional analysis performed using NHANES 2001-2006.We analyzed a nationally representative sample U.S. children...
Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial involved 138 children and young adults who were randomized cyclosporin or mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome proteinuria remission. DNA was available from 94 subjects genotyped APOL1 renal variants, two alleles comprising genotype. Two present 27 subjects, whom four did not...
The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns injury kidney biopsies, but not specific to underlying pathobiology. Consequently, there are variable rates progression response therapy within diagnoses. Here, an unbiased transcriptomic-driven approach was used identify molecular pathways which shared by subgroups patients with either minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). Kidney tissue transcriptomic...
Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) poised to address these challenges. study has enrolled >850 pediatric adult patients with proteinuric glomerular who have contributed deep clinical, histologic, genetic, profiles...